Glyco-Nanoparticles for Applications in Advance Nanomedicine

Livrables

Four training weeks implemented

Supervisory and Scientific Advisory Boards

Set up of the Supervisory board (SB) and the Scientific Advisory Board (SAB).

An estimated 30 peer reviewed scientific publications possibly including a special issue in Polymer Chemistry NanoScale ACSNano

Proejct website

NanoCarb website established and online.

Wikipedia page

Creation of a Wikipedia a dedicated page on glyco-nanotechnology following the Wikipedia rules and guidelines. It will give an overview of the aims and objectives of this project and it will be written in a language that will not require a prior learning experience in science.

Publications

Photo-Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles

Auteurs: Patricia Pérez Schmidt, Katiuscia Pagano, Cristina Lenardi, Marta Penconi, Ruth Mateu Ferrando, Claudio Evangelisti, Luigi Lay, Laura Ragona, Marcello Marelli, Laura Polito
Publié dans:  Angewandte Chemie (International edition), 2022, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202210140

Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers Using an Analytical Approach Based on spICP-SFMS and EAF4-MALS

Auteurs: Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke.
Publié dans: Nanomaterials, Numéro 11(10), 2021, ISSN 1847-9804
Éditeur: MDPI
DOI: 10.3390/nano11102720

Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation

Auteurs: Ishibe, Toru; Gonzalez-Martinez, Natalia; Georgiou, Panagiotis G.; Murray, Kathryn A.; Gibson, Matthew I.
Publié dans: ACS Polymers Au, Numéro 2, 6, 2022, Page(s) 449–457, ISSN 2694-2453
Éditeur: American Chemical Society
DOI: 10.1021/acspolymersau.2c00028

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow.

Auteurs: Alexander N. Baker; George W. Hawker-Bond; Panagiotis G. Georgiou; Simone Dedola; Robert A. Field; Matthew I. Gibson
Publié dans: Chem Soc Rev, Numéro 16, 2022, ISSN 1460-4744
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2cs00267a

Long-term retention of gold nanoparticles in the liver is not affected by their physicochemical characteristics

Auteurs: Jennifer Fernandez Alarcon, Mahmoud Soliman, Tanja Ursula Lüdtke, Eva Clemente, Marko Dobricic, Martina B. Violatto, Alessandro Corbelli, Fabio Fiordaliso, Chiara Cordiglieri, Laura Talamini, Giovanni Sitia, Sergio Moya, Paolo Bigini and Marco P. Monopoli
Publié dans: Nanoscale, 2023, ISSN 2040-3372
Éditeur: RSC
DOI: 10.1039/d3nr00685a

The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation.

Auteurs: Alessia Pancaro; Michal Szymonik; Panagiotis G. Georgiou; Alexander N. Baker; Marc Walker; Peter Adriaensens; Jelle Hendrix; Matthew I. Gibson; Inge Nelissen
Publié dans: Nanoscale, Numéro 13, 2021, Page(s) 10837-10848, ISSN 2040-3372
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1nr01548f

Gold nanoparticle-based platforms for vaccine development

Auteurs: Ruth Mateu Ferrando; Luigi Lay; Laura Polito
Publié dans: Drug Discovery Today: Technologies, Numéro 1, 2021, Page(s) 57-67, ISSN 1740-6749
Éditeur: Elsevier BV
DOI: 10.1016/j.ddtec.2021.02.001

Egg yolk sialylglycopeptide: purification, isolation and characterization of N-glycans from minor glycopeptide species

Auteurs: Javier Mauricio Melo Diaz, Alan B. Moran, Simon R. Peel, Jenifer L. Hendel, Daniel I.R. Spencer
Publié dans: Organic & Biomolecular Chemistry, 2022, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2ob00615d

Ice recrystallisation inhibiting polymer nano-objects via saline-tolerant polymerisation-induced self-assembly

Auteurs: Panagiotis G. Georgiou, Ioanna Kontopoulou, Thomas R. Congdon, Matthew I. Gibson
Publié dans: Materials Horizons, Numéro 7/7, 2020, Page(s) 1883-1887, ISSN 2051-6347
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0mh00354a

End-functionalized poly(vinylpyrrolidone) for ligand display in lateral flow device test lines

Auteurs: Alexander N. Baker; Thomas R. Congdon; Sarah-Jane Richards; Panagiotis G. Georgiou; Marc Walker; Simone Dedola; Robert A. Field; Robert A. Field; Matthew I. Gibson
Publié dans: ACS Polym. Au, Numéro 30, 2021, Page(s) 69–79, ISSN 2694-2453
Éditeur: American Chemical Society
DOI: 10.1021/acspolymersau.1c00032

 Influence of the block copolypeptide surfactant structure on the size of polypeptide nanoparticles obtained by mini emulsion polymerisation

Auteurs: Nicola Judge, Dražen Pavlović, Evelin Moldenhauer, Paul Clarke, Ruairi Brannigan, Andreas Heise
Publié dans: Polymer Chemistry, Numéro 13, 2022, ISSN 1759-9962
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2py00331g

Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods

Auteurs: Panagiotis G. Georgiou; Collette S. Guy; Muhammad Hasan; Ashfaq Ahmad; Sarah-Jane Richards; Alexander N. Baker; Neer V. Thakkar; Marc Walker; Sarojini Pandey; Neil R. Anderson; Dimitris Grammatopoulos; Matthew I. Gibson
Publié dans: ACS Macro Lett., Numéro 11,3, 2022, Page(s) 317-322, ISSN 2161-1653
Éditeur: American Chemical Society
DOI: 10.1021/acsmacrolett.1c00716

Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition.

Auteurs: Panagiotis G. Georgiou; Huba L Marton; Alexander N. Baker; Thomas R. Congdon; Thomas F. Whale; Matthew I. Gibson
Publié dans: Journal of the American Chemical Society, Numéro 31, 2021, Page(s) 7449–7461, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.1c01963

Lateral Flow Glyco-Assays for the Rapid and Low-Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance

Auteurs: Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, and Matthew I. Gibson
Publié dans: Advanced Healthcare Materials, 2022, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/adhm.202101784

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding

Auteurs: Ashfaq Ahmad; Panagiotis G. Georgiou; Alessia Pancaro; Muhammad Hasan; Inge Nelissen; Matthew I. Gibson
Publié dans: Nanoscale, Numéro 14, 2022, Page(s) 13261-13273, ISSN 2040-3372
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2nr01818g

Targeting Ultrasmall Gold Nanoparticles with cRGD Peptide Increases the Uptake and Efficacy of Cytotoxic Payload

Auteurs: Richard D. Perrins; Lee-Anne McCarthy; Angela Robinson; Kelly L. Spry; Valentin Cognet; Avelino Ferreira; John Porter; Cristina Espinosa Garcίa; Miguel Ángel Rodriguez; Diana Lopez; Ibon Perera; Kelly Conlon; Africa Barrientos; Tom Coulter; Alessandro Pace; Sarah J. M. Hale; Enrico Ferrari; Csanad Z. Bachrati
Publié dans: Nanomaterials, Numéro 12, 2022, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano12224013

Joint Forces of HR-Spicp-MS and EAF4-MALS for Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers

Auteurs: Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke
Publié dans:  Materials Proceedings, 2021, ISSN 2673-4605
Éditeur: MDPI
DOI: 10.3390/iocn2020-07923

“Tuning aggregative versus non-aggregative lectin binding with glycosylated nanoparticles by the nature of the polymer ligand”

Auteurs: Panagiotis G. Georgiou, Alexander N. Baker, Sarah-Jane Richards, Antonio Laezza, Marc Walker, Matthew I. Gibson
Publié dans: Journal of Materials Chemistry B, 2019, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9tb02004g

Probing the glycans accessibility of the nanoparticles biomolecular corona

Auteurs: Clemente, Eva
Publié dans: Journal of Colloid and Interface Science, Numéro 613, 2022, Page(s) 563-574, ISSN 0021-9797
Éditeur: Academic Press
DOI: 10.5281/zenodo.5020817

Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice

Auteurs: Georgiou, Panagiotis G.; Kinney, Nina L. H.; Kontopoulou, Ioanna; Baker, Alexander N.; Hindmarsh, Steven A.; Bissoyi, Akalabya; Congdon, Thomas R.; Whale, Thomas F.; Gibson, Matthew I.
Publié dans: Biomacromolecules, Numéro 23, 2022, Page(s) 5285–5296, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.2c01097

High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding

Auteurs: Nicola Judge; Panagiotis G. Georgiou; Akalabya Bissoyi; Ashfaq Ahmad; Andreas Heise; Matthew I. Gibson
Publié dans:  Biomacromolecules, 2023, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.2c01487

New nanostructures inhibiting human mannose binding lectin identified by a novel surface plasmon resonance assay

Auteurs: Gizem Erol; Patricia Perez Schmidt; Alessia Pancaro; Javier M. Melo Diaz; Africa G. Barrientos; John Porter; Laura Polito; Michal Szymonik; Inge Nelissen; Daniel I.R. Spencer; Arianna Piotti; Marten Beeg; Maria-Grazia De Simoni; Stefano Fumagalli; Marco Gobbi
Publié dans: Sensors and Actuators B: Chemical, Numéro 360, 2022, ISSN 0925-4005
Éditeur: Elsevier BV
DOI: 10.1016/j.snb.2022.131661

Glycan-Based Flow-Through Device for the Detection of SARS-COV-2

Auteurs: Alexander N. Baker, Sarah-Jane Richards, Sarojini Pandey, Collette S. Guy, Ashfaq Ahmad, Muhammad Hasan, Caroline I. Biggs, Panagiotis G. Georgiou, Alexander J. Zwetsloot, Anne Straube, Simone Dedola, Robert A. Field, Neil R. Anderson, Marc Walker, Dimitris Grammatopoulos, and Matthew I. Gibson
Publié dans: ACS Sensors, 2021, ISSN 2379-3694
Éditeur: American Chemical Society
DOI: 10.1021/acssensors.1c01470

Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output

Auteurs: Julian Micallef, Alexander N. Baker, Sarah-Jane Richards, Douglas E. Soutar, Panagiotis G, Georgiou, Marc Walker, Matthew I. Gibson
Publié dans: Materials Chemistry, 2022, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2ra06265h

Extraction and purification of a High Mannose type oligosaccharide from Phaseolus lunatus beans by oxidative release with sodium hypochlorite

Auteurs: Javier Mauricio Melo Diaz; Simon R. Peel; Daniel I.R. Spencer; Jenifer L. Hendel
Publié dans: Carbohydrate Research, Numéro 517, 2022, ISSN 0008-6215
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.carres.2022.108583

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