Risk Governance of Nanotechnology

Deliverables

Harmonised SOP for the resuspension of ENMs in biological media and in vitro dosimetry

Harmonised protocol for the resuspension of ENMs in biological media eg cell culturemedium or environmental medium A computational model that allows the prediction of sedimentation over time will be implemented in a guidance document for the accurate dosimetry in submerged in vitro experiments

Consolidated pre-validated guidance document on the determination of ENMs endotoxins content

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties endotoxins content of ENMs

Report on the RG framework and decision trees

Based on the framework proposed by IRGC and recent developments in the field of RG of nanotechnology eg the ERMF outcomes of NANoREG NanoReg2 caLIBRAte and other projects an RG framework will be adopted and refined in RiskGONE

Consolidated pre-validated guidance document on zeta potential determination

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties zeta potential of ENMs

Consolidated pre-validated guidance document on particle counting

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties particle counting of ENMs

End-user training materials for RGC and research community (WP5)

This task will be linked to WP7 and will provide enduser training material to facilitate the generation of anappropriate stakeholder communications toolbox to promote impact and ensure wide dissemination ensuringsustainability of the RiskGONE project outputs The training materials generated will include SOPs for the testsystems that prove to be successful in the roundrobin exercises and webinar content targeted at partners within theconsortium for the Council and also for the scientific community

Report on pre-validated high throughput (in vitro) and miniaturised (in vivo) methods for ecotoxicity testing

Refinement of innovative in vitro models and mechanistically relevant highthroughput assays for nanosafety ecotoxicological hazard assessment

Documented protocols, data capture, and meta data templates for revised OECD tests, and pre-validated alternative test methods

Following assay adaptation draft guidance documents will be written prepared as harmonised test methods ensuringthat endusers are able to easily apply the tests in their own laboratories The final harmonised SOPs will also be used to propose amendments to the existingOECD TGs both in support of the Malta project phase 2 efforts and also extending the reach of the Maltaproject contributing to ongoing proposed revisions of ECHAs annexes for nanosubstances under REACH

Draft guidelines regarding the correct implementation of risk transfer in insurance models.

Draft guidelines will also be produced for updating insurance models Currently insurers use outdated models to access risk or none at all If an adverse event occurs this puts them in a poor position to respond proportionally We will first assess those insurance models that exist and their current deployment This will allow us to replicate andwhere appropriate improve upon existing insurance communication lines In this way human and environmental risk indicators can be adopted into a distribution method for underwriters that is both fitforpurpose and is updated with uptodate scientific outputs

Report on nano-specific sex differences to direct future hazard assessment approaches

Metaanalysis of existing in vivo and in vitro primary cell data to evaluate the influence of sex differences on ENM toxicity IMI5354 This information will be used to compile a white paper on the topic of nanospecific gender differences to direct future RA approaches

Report on feedback on an initial draft of DEB-based AOP for chronic ecotoxicity to ENMs from a workshop at M24

Report on feedback on an initial draft of DEBbased AOP for chronic ecotoxicity to ENMs from a workshopat M24

Draft guidelines regarding bringing together risk indicators in an overall MCA framework

In Task 36 draft guidelines will be produced for bringing together individual risk components as described in tasks 31 to 35 in an MCA matrix The analysis aims to take into account the uncertainty associated with the indicators as well as acceptablethresholds for the risks and benefits

Report on the expert meeting AOP draft review

Evaluation and definition of AOPs specific for ENM

Report on the final harmonised SOPs used to propose amendments to the existing OECD TGs (WP6)

Evaluation and adaptation of in vivo ecotoxicity and environmental safety testing OECD TGs to enable ENM risk governance

End-user training materials for RGC and research community (WP6)

This task will be linked to WP7 and will provide enduser training material to facilitate the generation of anappropriate stakeholder communications toolbox to promote impact and ensure wide dissemination ensuringsustainability of the RiskGONE project outputs The training materials generated will include SOPs for the testsystems that prove to be successful in the RR exercises and webinar content targeted at partners within theconsortium for the RG Council and also for the scientific community

Demonstration of the RiskGONE Cloud Platform through selected case studies

In this task the use of the RG decision support tool will be demonstrated by applying the RG Cloud Platform on real cases selected in WP3 involving RG considerations of nanoenabled and nanoderived products

Consolidated pre-validated guidance document on effective density

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties effective density of ENMs

Report on DEB-based AOP for chronic ecotoxicity to ENMs, and extension to multi-generational effects

Report on DEBbased AOP for chronic ecotoxicity to ENMs and extension to multigenerational effects Develop AOPs for chronic ecotoxicity and multigenerational assessment of ENMs

Training material for WP2 and WP7 regarding how to use the draft guidelines

The role of WP3 is to gather available data and produce draft guidelines on risk and benefit assessment Information derived here will be instrumental support for the RGC which is created implemented and maintained in WP2 The input for the WP will derive from various sources including WPs 46 The output of WP3 will be methodology draft guidelines for overall riskbenefit calculation from task 37 which will then feed into WP2 to provide scientific support for an RG framework Training material will also be produced for WP7

Draft guidelines regarding an ethical impact assessment

Draft guidelines for an ethical impact assessment will be produced based on the current guidance given by the CEN Workshop Agreement part 2 CWA 1714522017 E

Draft guidelines regarding the quantification of lifecycle environmental and human health risk indicators

Draft guidelines will be produced for the application of LCA methods to ENMs to include a broader perspective on human and environmental risks with the ENM value chain or life cycle These guidelines will be based on ISO 140402006 and 140442006 environmental management standards for LCA but will highlight particular considerations that should be made when applied to ENMs

Report on the applicability of OECD TGs for determination of the environmental fate of ENMs

Task 42 will verify the applicability for ENMs of the OECD methodology for environmental fate of chemicals If necessary adaptation to the selected TGs will be proposed

Draft guidelines on the societal acceptance of nanomaterials considering risk and benefit perception

Draft guidelines will be produced for analysing the perceptions of risk associated with the use of nanomaterials insociety by developing a sample questionnaire

Report on the final harmonised SOPs used to propose amendments to the existing OECD TGs (WP5)

Following the RR draft guidelines will be prepared as harmonised test methods ensuring that endusers are able to easily apply the tests in their own laboratories The final harmonised SOPs will also be used to propose amendments to the existing OECD TGs both in support of the Malta project phase 2 efforts and also extending the reach of the Malta project contributing to ongoing proposed revisions of ECHAs annexes fornanosubstances under REACH

Consolidated pre-validated guidance document on hydrodynamic diameter and size distribution determination

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties hydrodynamic diameter and size distribution of ENMs

Report on the proof of concept evaluation of SOPs for innovative in vitro models and mechanistically relevant assays for nanosafety human hazard assessment

Evaluation and refinement of innovative in vitro models and mechanistically relevant assays for human hazard assessment

Report on evaluation of stakeholder feedback through workshops and conferences

The design of the stakeholder communications tool is very much dependent upon the design of the operating practices and the issues of reflection of the NMBP13 cooperation so will be operational after the structure and web portal design are finalised Furthermore social media platforms like LinkedIn will be used to gather feedback and raise awareness In addition to virtual communication channels direct formats such as workshops and conferences will be used especially together with the other NMBP13 projects as described in Task 71 The analysis of the feedback received on the preliminary work results will be used to refine the strategy with regard to the final products of RiskGONE

Report on the harmonised SOPs on high throughput approaches for hazard assessment of ENMs

Evaluation and refinement of mechanistically relevant high throughput and high content analysis methods for human hazard assessment Report on the harmonised SOPs on high throughput approaches for hazard assessment of ENMs

Report on nano-specific gender differences to direct future ERA approaches

Report on nanospecific gender differences to direct future ERA approaches

Draft guidelines regarding the quantification of macro-economic benefits

Draft guidelines will be produced for quantifying economic benefits relating to GDP and job growth given the human and environment risk (tasks 3.1, 3.2 and 3.4), from a macro-economic viewpoint. This will include economic approaches such as Willingness-To-Pay, and will show how different regulatory approaches positively/negatively impact the economic opportunities and job creation using a Welfare Economics model.

Mapping, analysis and selection of operating practices of governance bodies

As the NanoReg2 project undertook a mapping exercise of bodies potentially interesting to the RGC, the resulting confidential deliverable will be used as a basis for the work of Task 7.3. Existing data will be carefully checked and updated, if needed, taking into account EU, national and international bodies.

Consolidated pre-validated guidance document on the dispersability of ENMs

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties dispersability of ENMs

Project website, house style, and social media profiles (Twitter, LinkedIn) finalized

A set of communication tools will help to keep interested partners and stakeholders (public bodies, regulators, civil society, industry, general public, etc.) updated on project developments and results.

The final version of RiskGONE Database and Cloud Platform

This task will build RiskGONE’s RG decision support tool, i.e., the RiskGONE Cloud Platform, by implementingthe decisions trees developed in Task 2.2 and including the guidance documents delivered by WP3, WP4, WP5, andWP6. Within this task, the open architecture and the APIs will be defined, supporting the technical and semanticinteroperability with RiskGONE’s database (T2.3).Shared responsibility IDEA/NovaM

Publications

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

Author(s): Sivakumar Murugadoss, Frederic Brassinne, Noham Sebaihi, Jasmine Petry, Stevan M. Cokic, Kirsten L. Van Landuyt, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet, Sybille van den Brule
Published in: Particle and Fibre Toxicology, Issue 17/1, 2020, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-020-00341-7

Practices and Trends of Machine Learning Application in Nanotoxicology

Author(s): Irini Furxhi, Finbarr Murphy, Martin Mullins, Athanasios Arvanitis, Craig A. Poland
Published in: Nanomaterials, Issue 10/1, 2020, Page(s) 116, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10010116

An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform

Author(s): Nikolaos Cheimarios; Barbara Pem; Andreas Tsoumanis; Krunoslav Ilić; Ivana Vinković Vrček; Georgia Melagraki; Dimitrios Bitounis; Panagiotis Isigonis; Maria Dusinska; Iseult Lynch; Philip Demokritou; Antreas Afantitis
Published in: 12, Issue 14, 2022, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12223935

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

Author(s): El Yamani, Naouale; Rundén-Pran, Elise; Collins Andrew R.; Longhin, Eleonora M.; Elje, Elisabet; Hoet, P.; Vinković Vrček, Ivana; Doak, Shareen H.; Fessard, Valerie; Dusinska, Maria
Published in: Frontiers in Toxicology, Issue 58, 2022, ISSN 2673-3080
Publisher: Frontiers

Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface

Author(s): Murugadoss, Sivakumar; Mülhopt, Sonja; Diabaté, Silvia; Ghosh, Manosij; Paur, Hanns-Rudolf; Stapf, Dieter; Weiss, Carsten; Hoet, Peter H.
Published in: Nanomaterials, Vol 11, Iss 3226, p 3226 (2021), Issue 22, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11123226

Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake

Author(s): Naouale El Yamani a 1, Laura Rubio b 1, Alba García-Rodríguez b, Alena Kažimírová c, Elise Rundén-Pran a, Barančoková Magdalena c, Ricard Marcos b, Maria Dusinska
Published in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2022, ISSN 0027-5107
Publisher: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503545

Thermodynamic Parameters at Bio-Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO2, and TiO2.

Author(s): Aurica Precupas; Daniela Gheorghe; Alina Botea-Petcu; Anca Ruxandra Leonties; Romica Sandu; Vlad Tudor Popa; Espen Mariussen; El Yamani Naouale; Elise Rundén-Pran; Verónica I Dumit; Ying Xue; Mihaela Roxana Cimpan; Maria Dusinska; Andrea Haase; Speranta Tanasescu
Published in: Chemical Research in Toxicology, Issue 1, 2020, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.9b00468

Tyre wear nanoparticles as test for a nano risk governance framework

Author(s): Pieter van Broekhuizen, Arto Säämänen, Daan Schuurbiers, Panagiotis Isigonis, Keld A. Jensen, Dana Kühnel, Kees Le Blansch
Published in: Frontiers in Environmental Science, 2022, ISSN 2296-665X
Publisher: Frontiers
DOI: 10.3389/fenvs.2022.1045246

Reduction of Health Care-Associated Infections (HAIs) with Antimicrobial Inorganic Nanoparticles Incorporated in Medical Textiles: An Economic Assessment

Author(s): Finbarr Murphy, Anat Tchetchik, Irini Furxhi
Published in: Nanomaterials, Issue 10/5, 2020, Page(s) 999, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10050999

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Author(s): Elisabeth Elje, Espen Mariussen, Oscar H. Moriones, Neus G. Bastús, Victor Puntes, Yvonne Kohl, Maria Dusinska, Elise Rundén-Pran
Published in: Nanomaterials, Issue 10/3, 2020, Page(s) 545, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10030545

Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study

Author(s): Marija Ćurlin, Rinea Barbir, Sanja Dabelić, Marija Ljubojević, Walter Goessler, Vedran Micek, Irena Žuntar, Mirela Pavić, Lucija Božičević, Ivan Pavičić & Ivana Vinković Vrček
Published in: Particle and Fibre Toxicology, 2021, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-021-00425-y

Embedding Ethical Impact Assessment in Nanosafety Decision Support

Author(s): Ineke Malsch, Panagiotis Isigonis, Maria Dusinska, Evert A. Bouman
Published in: Small, Issue 23 July 2020, 2020, Page(s) 2002901, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202002901

ELIXIR and Toxicology: a community in development

Author(s): Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Published in: F1000Research, Issue 7, 2021, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1

Updating traditional regulatory tests for use with novel materials:Nanomaterial toxicity testing with Daphnia magna

Author(s): Fatima Nasser, Iseult Lynch
Published in: Safety Science, 2019, ISSN 0925-7535
Publisher: Elsevier BV

The risk perception of nanotechnology: evidence from twitter

Author(s): Finbarr Murphy, Ainaz Alavi, Martin Mullins, Irini Furxhi,Arash Kiad, Myles Kingston
Published in: RSC Advances, 2022, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra09383e

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report

Author(s): Shareen H Doak; Cristina Andreoli; Michael J Burgum; Qasim Chaudhry; Eric A J Bleeker; Cecilia Bossa; Josefa Domenech; Damjana Drobne; Valérie Fessard; Nina Jeliazkova; Eleonora Longhin; Elise Rundén-Pran; Maciej Stępnik; Naouale El Yamani; Julia Catalán; Maria Dusinska
Published in: "Mutagenesis, 2023, pp.1-9. ⟨10.1093/mutage/gead017⟩", Issue 44, 2023, ISSN 1464-3804
Publisher: oxford academic
DOI: 10.1093/mutage/gead017

Using AOP-Wiki to support the ecotoxicological risk assessment of nanomaterials: first steps in the development of novel adverse outcome pathways

Author(s): Karolina Jagiello; Beata Judzinska; Anita Sosnowska; Iseult Lynch; Sabina Halappanavar; Tomasz Puzyn
Published in: ORCID, Issue 50, 2022, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en01127h

Status,implicationsandchallengesofEuropean safeandsustainablebydesignparadigms applicabletonanomaterialsandadvanced materials

Author(s): Irini Furxhi, Anna Costa, Socorro Vázquez-Campos, Carlos Fito-López, Danail Hristozov, Juan Antonio Tamayo Ramos, Susanne Resch, Margherita Cioffi, Steffi Friedrichs, Cris Rocca, Eugenia Valsami-Jones, Iseult Lynch, Sánchez Jiménez Aracelil and Lucian Farcal
Published in: RSC Sustainability, 2023, ISSN 2753-8125
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2su00101b

Passage of exogeneous fine particles from the lung into the brain in humans and animals

Author(s): Yu Qi; Shuting Wei; Tao Xin; Chuanjiang Huang; Yichen Pu; Jinzhu Ma; Changbin Zhang; Yajun Liu; Iseult Lynch; Sijin Liu
Published in: Crossref, Issue 36, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2117083119

A data reusability assessment in the nanosafety domain based on the NSDRA framework followed by an exploratory quantitative structure activity relationships (QSAR) modeling targeting cellular viability

Author(s): Irini Furxhi a b, Egon Willighagen c, Chris Evelo c, Anna Costa d, Davide Gardini d, Ammar Ammar
Published in: Nanoimpact, 2023, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2023.100475

Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

Author(s): Yvonne Kohl; Elise Rundén-Pran; Espen Mariussen; Michelle Hesler; Naouale El Yamani; Eleonora Longhin; Maria Dusinska
Published in: 10, Issue 58, 2020, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10101911

Engineered Zn-based nano-pesticides as an opportunity for treatment of phytopathogens in agriculture

Author(s): Weichen Zhao a b, Yanwanjing Liu b c, Peng Zhang d e, Pingfan Zhou a, Zhangguo Wu b c, Benzhen Lou a, Yaqi Jiang a, Noman Shakoor a, Mingshu Li a, Yuanbo Li a, Iseult Lynch d, Yukui Rui a f g, Zhiqiang Tan
Published in: NanoImpact, 2022, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2022.100420

Advanced Respiratory Models for Hazard Assessment of Nanomaterials. Performance of Mono-, Co- and Tricultures

Author(s): Laura Maria Azzurra Camassa; Elisabeth Elje; Espen Mariussen; Eleonora Marta Longhin; Maria Dusinska; Shan Zienolddiny-Narui; Elise Rundén-Pran
Published in: 12, Issue 38, 2023, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12152609

The analytical quest for sub-micron plastics in biological matrices

Author(s): FazelAbdolahpur Monikh, Martina G.Vijver, Denise M.Mitrano, Heather Leslie, Zhiling Guo, Peng Zhang, Iseult Lynch, Eugenia Valsami-Jones, Willie J.G.M. Peijnenburg
Published in: Nanotoday, 2021, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2021.101296

A strategy towards the generation of testable adverse outcome pathways for nanomaterials

Author(s): Sivakumar Murugadoss; Ivana Vinković Vrček; Barbara Pem; Karolina Jagiello; Beata Judzinska; Anita Sosnowska; Marvin Martens; Egon Willighagen; Tomasz Puzyn; Maria Dusinska; Mihaela Roxana Cimpan; Valérie Fessard; Peter Hoet
Published in: 38, Issue 1, 2021, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2102191

Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

Author(s): Suchi Smita Gupta 1,Krishna P. Singh 1,Shailendra Gupta 1ORCID,Maria Dusinska 2ORCID andQamar Rahman Qamar Rahman ScilitPreprints.orgGoogle Scholar 3,*
Published in: nanomaterials, 2022, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12101708

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Author(s): Amaya Azqueta; Helga Stopper; Bojana Zegura; Maria Dusinska; Peter Møller
Published in: 503520, Issue 45, 2022, ISSN 1879-3592
Publisher: Elsevier
DOI: 10.1016/j.mrgentox.2022.503520

Exceptional photo-elimination of antibiotic by a novel Z-scheme heterojunction catalyst composed of nanoscale zero valent iron embedded with carbon quantum dots (CQDs)-black TiO2

Author(s): Xi Wu a, Xiangyu Wang a b, Iseult Lynch b, Zhiling Guo b, Peng Zhang b, Lisi Wu b, Ping Ning a, Nanqi Ren
Published in: Journal of Hazardous Materials, 2023, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2023.132323

Is aggregated synthetic amorphous silica toxicologically relevant?

Author(s): Sivakumar Murugadoss, Sybille van den Brule, Frederic Brassinne, Noham Sebaihi, Jorge Mejia, Stéphane Lucas, Jasmine Petry, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet
Published in: Particle and Fibre Toxicology, Issue 17/1, 2020, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-019-0331-3

Defining the Surface Oxygen Threshold That Switches the Interaction Mode of Graphene Oxide with Bacteria

Author(s): Zhiling Guo*, Peng Zhang*, Changjian Xie*, Evangelos Voyiatzis, Klaus Faserl, Andrew J. Chetwynd, Fazel Abdolahpur Monikh, Georgia Melagraki, Zhiyong Zhang, Willie J. G. M. Peijnenburg, Antreas Afantitis, Chunying Chen, and Iseult Lynch
Published in: ACS nano, 2022, ISSN 1936-086X
Publisher: ACS publications
DOI: 10.1021/acsnano.2c10961

Strategies to improve photocatalytic activity of nanoscale zero valent iron decorated MoS2: Construction of novel S-scheme nanoflower heterojunction with advanced visible-light degradation of tetracycline

Author(s): Xi Wu a, Xiangyu Wang a b, Iseult Lynch b, Zhiling Guo b, Peng Zhang b, Lisi Wu b, Youxue Deng a, Yu Xie a, Ping Ning a, Nanqi Ren
Published in: Journal of Cleaner Production, 2023, ISSN 0959-6526
Publisher: Elsevier BV
DOI: 10.1016/j.jclepro.2023.135865

European Registry of Materials: global,unique identifers for (undisclosed)nanomaterials

Author(s): Jeaphianne van Rijn1* , Antreas Afantitis2 , Mustafa Culha3 , Maria Dusinska4 , Thomas E. Exner5 , Nina Jeliazkova6 , Eleonora Marta Longhin4 , Iseult Lynch7 , Georgia Melagraki2 , Penny Nymark8 , Anastasios G. Papadiamantis2,7 , David A. Winkler9,10,11 , Hulya Yilmaz3 and Egon Willighagen1
Published in: Journal of Cheminformatics, 2022, ISSN 1758-2946
Publisher: Chemistry Central
DOI: 10.1186/s13321-022-00614-7

WikiPathways: connecting communities.

Author(s): Martens, Marvin; Ammar, Ammar; Riutta, Anders; Waagmeester, Andra; Slenter, Denise N; Hanspers, Kristina; A. Miller, Ryan; Digles, Daniela; Lopes, Elisson N; Ehrhart, Friederike; Dupuis, Lauren J; Winckers, Laurent A; Coort, Susan L; Willighagen, Egon L; Evelo, Chris T; Pico, Alexander R; Kutmon, Martina
Published in: Nucleic acid research, Issue 6, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1024

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Author(s): Sivakumar Murugadoss1,2*, Ivana Vinković Vrček3*, Alexandra Schaffert4, Martin Paparella4, Barbara Pem5, Anita Sosnowska6, Maciej Stępnik6, Marvin Martens7, Egon L. Willighagen7, Tomasz Puzyn6,8,Mihaela RoxanaCimpan9, Frauke Lemaire2, Birgit Mertens1, Maria Dusinska10, Valérie Fessard11and Peter H.Hoet
Published in: ALTEX, 2023, ISSN 1868-8551
Publisher: springer
DOI: 10.14573/altex.2305011

The alamar blue assay in the context of safety testing of nanomaterials

Author(s): Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Dusinska, Maria
Published in: 10, Issue 57, 2022, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2022.981701

Surface Functionalization of Graphene-Based Materials: Biological Behavior, Toxicology, and Safe-By-Design Aspects

Author(s): Zhiling Guo, Swaroop Chakraborty, Fazel Abdolahpur Monikh, Dimitra-Danai Varsou, Andrew J Chetwynd, Antreas Afantitis, Iseult Lynch, Peng Zhang
Published in: advanced biology, 2021, ISSN 2701-0198
Publisher: Wiley
DOI: 10.1002/adbi.202100637

Assessing the Toxicological Relevance of NanomaterialAgglomerates and Aggregates Using Realistic Exposure In Vitro

Author(s): Sivakumar Murugadoss, Lode Godderis, Manosij Ghosh, Peter H. Hoet
Published in: Nanomaterials, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11071793

From principles to reality. FAIR implementation in the nanosafety community

Author(s): Verónica I. Dumit a, Ammar Ammar b, Martine I. Bakker c, Miguel A. Bañares d, Cecilia Bossa e, Anna Costa f, Hilary Cowie g, Damjana Drobne h, Thomas E. Exner i, Lucian Farcal j, Steffi Friedrichs k, Irini Furxhi l m, Roland Grafström n v, Andrea Haase a, Martin Himly o, Nina Jeliazkova p, Iseult Lynch q, Dieter Maier r, Cornelle W. Noorlander c, Hyun Kil Shin s, Galo J.A.A. Soler-Illia t, Blan
Published in: Nano Today, 2023, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2023.101923

Knowledge about nanotechnology and intention to use nanomaterials: A comparative study among dental students in Norway and Romania

Author(s): Victoria Xenaki, Mihaela Cuida Marthinussen, Daniela Elena Costea, Andreea Cristiana Didilescu, Cristiano Susin, Mihaela Roxana Cimpan, Anne Nordrehaug Åstrøm
Published in: European Journal of Dental Education, 2019, ISSN 1600-0579
Publisher: Wiley Online Library

Nanomaterial Transformation in the Soil–Plant System: Implications for Food Safety and Application in Agriculture

Author(s): Peng Zhang,* Zhiling Guo, Zhiyong Zhang,* Hualing Fu, Jason C. White, and Iseult Lynch
Published in: Small, 2020, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202000705

Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials

Author(s): Panagiotis Isigonis, Antreas Afantitis, Dalila Antunes, Alena Bartonova, Ali Beitollahi, Nils Bohmer, Evert Bouman, Qasim Chaudhry, Mihaela Roxana Cimpan, Emil Cimpan, Shareen Doak, Damien Dupin, Doreen Fedrigo, Valérie Fessard, Maciej Gromelski, Arno C. Gutleb, Sabina Halappanavar, Peter Hoet, Nina Jeliazkova, Stéphane Jomini, Sabine Lindner, Igor Linkov, Eleonora Marta Longhin, Iseult Lynch, I
Published in: Small, Issue Volume 16, Issue 36, 2020, Page(s) 2003303, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202003303

Extra-Pulmonary Translocation of Exogenous Ambient Nanoparticles in the Human Body

Author(s): Yu Qi, Yucai Chen, Tian Xia*, Iseult Lynch*, and Sijin Liu
Published in: ACS nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c09299

Predicting intention of Norwegian dental health-care workers to use nanomaterials: An application of the augmented theory of planned behavior

Author(s): Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena; Breivik, Kyrre; Lie, Stein Atle; Cimpan, Mihaela-Roxana; Åstrøm, Anne-Kristine N
Published in: European Journal of Oral Sciences, 2021, ISSN 1600-0722
Publisher: Wiley
DOI: 10.1111/eos.12821

FAIR assessment tools: evaluating use and performance

Author(s): N.A. Krans a, A. Ammar b, P. Nymark c, E.L. Willighagen b, M.I. Bakker a, J.T.K. Quik
Published in: nanoimpact, 2022, ISSN 2452-0748
Publisher: science direct
DOI: 10.1016/j.impact.2022.100402

A Semi-Automated Workflow for FAIR Maturity Indicators in the Life Sciences.

Author(s): Ammar Ammar; Serena Bonaretti; Laurent A. Winckers; Joris T.K. Quik; Martine Bakker; Dieter Maier; Iseult Lynch; Jeaphianne van Rijn; Egon Willighagen
Published in: Issue 10, Issue 5, 2020, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10102068

Construction of urchin-like core-shell Fe/Fe2O3@UiO-66 hybrid for effective tetracycline reduction and photocatalytic oxidation

Author(s): Xiangyu Wang a b, Min Jiang a, Iseult Lynch b, Zhiling Guo b, Peng Zhang b, Lisi Wu b, Jun Ma
Published in: Environmental Pollution, 2023, ISSN 1873-6424
Publisher: Elsevier
DOI: 10.1016/j.envpol.2023.122280

Editorial: Exploring impacts of combined exposures to particles and chemicals on immune reactions across living organisms

Author(s): Diana Boraschi, Albert Duschl, Iseult Lynch, Tobias Stoeger
Published in: Frontiers in toxicology, 2023, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2023.1148374

Design of cryogel based CNTs-anchored polyacrylonitrile honeycomb film with ultra-high S-NZVI incorporation for enhanced synergistic reduction of Cr(VI)

Author(s): Kaini Yang a, Xiangyu Wang a b, Iseult Lynch b, Zhiling Guo b, Peng Zhang b, Lisi Wu b, Jun Ma
Published in: Journal of Hazardous Materials, 2023, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2022.129923

Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance.

Author(s): Iseult Lynch; Antreas Afantitis; Dario Greco; Maria Dusinska; Miguel A. Bañares; Georgia Melagraki
Published in: Nanomaterials, Vol 11, Iss 121, p 121 (2021), Issue 4, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11010121

Effects of Titanium Dioxide Nanoparticles on the Hprt Gene Mutations in V79 Hamster Cells

Author(s): Alena Kazimirova, Naouale El Yamani, Laura Rubio, Alba García-Rodríguez, Magdalena Barancokova, Ricard Marcos, Maria Dusinska
Published in: Nanomaterials, Issue 10/3, 2020, Page(s) 465, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10030465

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

Author(s): Naouale El Yamani a, Espen Mariussen a b, Maciej Gromelski c, Ewelina Wyrzykowska c, Dawid Grabarek c, Tomasz Puzyn c d, Speranta Tanasescu e, Maria Dusinska a, Elise Rundén-Pran
Published in: nanotoday, 2022, ISSN 1878-044X
Publisher: Science direct
DOI: 10.1016/j.nantod.2022.101581

High-efficiency removal of tetracycline from water by electrolysis-assisted NZVI: mechanism of electron transfer and redox of iron

Author(s): Xiangyu Wang, Xiangmei Wang, Iseult Lynch and Jun Ma
Published in: RSC advances, 2023, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3ra00954h

Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials

Author(s): Elisabeth Elje; Espen Mariussen; Erin McFadden; Maria Dusinska; Elise Rundén-Pran
Published in: 407, Issue 36, 2023, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13030407

The colony forming efficiency assay for toxicity testing of nanomaterials—Modifications for higher-throughput

Author(s): Rundèn-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta; Dusinska, Maria
Published in: 2673-3080, Issue 39, 2022, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2022.983316

Daphnia as a model organism to probe biological responses to nanomaterials—from individual to population effects via adverse outcome pathways

Author(s): Katie Reilly1 Laura-Jayne A. Ellis1 Hossein Hayat Davoudi1 Suffeiya Supian1 Marcella T. Maia2 Gabriela H. Silva2 Zhiling Guo1* Diego Stéfani T. Martinez2 Iseult Lynch1*
Published in: Frontiers in toxicology, 2023, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2023.1178482

Cellular repair mechanisms triggered by exposure to silver nanoparticles and ionic silver in embryonic zebrafish cells

Author(s): Ana C. Quevedo; Iseult Lynch; Eugenia Valsami-Jones
Published in: Environmental Science Nano, Issue 1, 2021, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en00422k

Joint glossary of key terms related to data management and knowledge infrastructure / portal / platform

Author(s): Lynch, Iseult; Afantitis, Antreas; Bakker, Martine; Bouman, Evert; Drobna, Damjana; Jeliazkova, Nina; Winckers, Laurent; Willighagen, Egon
Published in: Issue 45, 2021
Publisher: zenodo
DOI: 10.5281/zenodo.6801183

Data Management for Nanotechnology Risk Governance

Author(s): Bakker, Martine; Drobne, Damjana; Jeliazkova, Nina; Antreas Afantitis; Willighagen, Egon; Lynch, Iseult
Published in: Issue 38, 2021
Publisher: EuroNanoForum2021
DOI: 10.5281/zenodo.4775085

Integrating ethics in risk governance of nanomaterials in tyres

Author(s): Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Published in: Issue 1, 2022
Publisher: Nanoweek2022
DOI: 10.5281/zenodo.6656456

Elucidating nanofibre genotoxic mechanisms: An interlaboratory approach

Author(s): Burgum, MJ; El-Yamani, N; Longhin, EM; Mariussen, E; Runden-Pran, E; Sosnowska, A; Reinosa, JJ; Alcolea-Rodriguez, V; Fernandez, JF; Portela, R; Puzyn, T; Banares, M; Clift, MJD; Dusinska, M; Doak, SH
Published in: 2022
Publisher: Environ. Mol. Mutagen

. Fostering regional stakeholder engagement in ethical risk governance of nanomaterials.

Author(s): Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Published in: Issue 1, 2021
Publisher: seeRRI
DOI: 10.5281/zenodo.5513753

Exploring User Interest in Ethical Tools for Nano-Risk Governance

Author(s): Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Published in: Issue 1, 2021
Publisher: EMMC
DOI: 10.5281/zenodo.4701051

Standardisation of mutagenicity testing approaches, tailored to the evaluation of engineered nanomaterials

Author(s): M.J. Burgum 1, N. El Yamani 2, A. Sosnowska 3, F. Stolinski 3, E.M. Longhin 2, E. Mariussen 2, E. Runden-Pran 2, G. Jenkins 1, M.J.D. Clift 1, T. Puzyn 3 4, M. Dusinska 2, S.H. Doak
Published in: 2021
Publisher: Elsevier
DOI: 10.1016/s0378-4274(21)00596-8

FAIR assessment of nanosafety data reusability with community standards

Author(s): Ammar Ammar; Chris Evelo; Egon Willighagen
Published in: Crossref, Issue 36, 2022, ISSN 2573-2293
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2022-l8vk8

Ethics of Nanomedicine

Author(s): Ineke Malsch
Published in: 2023
Publisher: Materials Research Proceedings
DOI: 10.21741/9781644902370-12

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