Deliverables
Harmonised protocol for the resuspension of ENMs in biological media eg cell culturemedium or environmental medium A computational model that allows the prediction of sedimentation over time will be implemented in a guidance document for the accurate dosimetry in submerged in vitro experiments
Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties endotoxins content of ENMs
Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties zeta potential of ENMs
Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties particle counting of ENMs
This task will be linked to WP7 and will provide enduser training material to facilitate the generation of anappropriate stakeholder communications toolbox to promote impact and ensure wide dissemination ensuringsustainability of the RiskGONE project outputs The training materials generated will include SOPs for the testsystems that prove to be successful in the roundrobin exercises and webinar content targeted at partners within theconsortium for the Council and also for the scientific community
Draft guidelines will also be produced for updating insurance models Currently insurers use outdated models to access risk or none at all If an adverse event occurs this puts them in a poor position to respond proportionally We will first assess those insurance models that exist and their current deployment This will allow us to replicate andwhere appropriate improve upon existing insurance communication lines In this way human and environmental risk indicators can be adopted into a distribution method for underwriters that is both fitforpurpose and is updated with uptodate scientific outputs
Report on feedback on an initial draft of DEBbased AOP for chronic ecotoxicity to ENMs from a workshopat M24
Evaluation and definition of AOPs specific for ENM
This task will be linked to WP7 and will provide enduser training material to facilitate the generation of anappropriate stakeholder communications toolbox to promote impact and ensure wide dissemination ensuringsustainability of the RiskGONE project outputs The training materials generated will include SOPs for the testsystems that prove to be successful in the RR exercises and webinar content targeted at partners within theconsortium for the RG Council and also for the scientific community
Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties effective density of ENMs
Draft guidelines for an ethical impact assessment will be produced based on the current guidance given by the CEN Workshop Agreement part 2 CWA 1714522017 E
Draft guidelines will be produced for the application of LCA methods to ENMs to include a broader perspective on human and environmental risks with the ENM value chain or life cycle These guidelines will be based on ISO 140402006 and 140442006 environmental management standards for LCA but will highlight particular considerations that should be made when applied to ENMs
Draft guidelines will be produced for analysing the perceptions of risk associated with the use of nanomaterials insociety by developing a sample questionnaire
Following the RR draft guidelines will be prepared as harmonised test methods ensuring that endusers are able to easily apply the tests in their own laboratories The final harmonised SOPs will also be used to propose amendments to the existing OECD TGs both in support of the Malta project phase 2 efforts and also extending the reach of the Malta project contributing to ongoing proposed revisions of ECHAs annexes fornanosubstances under REACH
Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties hydrodynamic diameter and size distribution of ENMs
Draft guidelines will be produced for quantifying economic benefits relating to GDP and job growth given the human and environment risk (tasks 3.1, 3.2 and 3.4), from a macro-economic viewpoint. This will include economic approaches such as Willingness-To-Pay, and will show how different regulatory approaches positively/negatively impact the economic opportunities and job creation using a Welfare Economics model.
As the NanoReg2 project undertook a mapping exercise of bodies potentially interesting to the RGC, the resulting confidential deliverable will be used as a basis for the work of Task 7.3. Existing data will be carefully checked and updated, if needed, taking into account EU, national and international bodies.
Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties dispersability of ENMs
A set of communication tools will help to keep interested partners and stakeholders (public bodies, regulators, civil society, industry, general public, etc.) updated on project developments and results.
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Publications
Author(s): Sivakumar Murugadoss, Frederic Brassinne, Noham Sebaihi, Jasmine Petry, Stevan M. Cokic, Kirsten L. Van Landuyt, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet, Sybille van den Brule
Published in: Particle and Fibre Toxicology, 17/1, 2020, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-020-00341-7
Author(s): Irini Furxhi, Finbarr Murphy, Martin Mullins, Athanasios Arvanitis, Craig A. Poland
Published in: Nanomaterials, 10/1, 2020, Page(s) 116, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10010116
Author(s): Aurica Precupas; Daniela Gheorghe; Alina Botea-Petcu; Anca Ruxandra Leonties; Romica Sandu; Vlad Tudor Popa; Espen Mariussen; El Yamani Naouale; Elise Rundén-Pran; Verónica I Dumit; Ying Xue; Mihaela Roxana Cimpan; Maria Dusinska; Andrea Haase; Speranta Tanasescu
Published in: Chemical Research in Toxicology, 1, 2020, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.9b00468
Author(s): Finbarr Murphy, Anat Tchetchik, Irini Furxhi
Published in: Nanomaterials, 10/5, 2020, Page(s) 999, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10050999
Author(s): Elisabeth Elje, Espen Mariussen, Oscar H. Moriones, Neus G. Bastús, Victor Puntes, Yvonne Kohl, Maria Dusinska, Elise Rundén-Pran
Published in: Nanomaterials, 10/3, 2020, Page(s) 545, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10030545
Author(s): Ineke Malsch, Panagiotis Isigonis, Maria Dusinska, Evert A. Bouman
Published in: Small, 23 July 2020, 2020, Page(s) 2002901, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202002901
Author(s): Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Published in: F1000Research, 7, 2021, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1
Author(s): Fatima Nasser, Iseult Lynch
Published in: Safety Science, 2019, ISSN 0925-7535
Publisher: Elsevier BV
Author(s): Finbarr Murphy, Ainaz Alavi, Martin Mullins, Irini Furxhi,Arash Kiad, Myles Kingston
Published in: RSC Advances, 2022, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra09383e
Author(s): FazelAbdolahpur Monikh, Martina G.Vijver, Denise M.Mitrano, Heather Leslie, Zhiling Guo, Peng Zhang, Iseult Lynch, Eugenia Valsami-Jones, Willie J.G.M. Peijnenburg
Published in: Nanotoday, 2021, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2021.101296
Author(s): Sivakumar Murugadoss; Ivana Vinković Vrček; Barbara Pem; Karolina Jagiello; Beata Judzinska; Anita Sosnowska; Marvin Martens; Egon Willighagen; Tomasz Puzyn; Maria Dusinska; Mihaela Roxana Cimpan; Valérie Fessard; Peter Hoet
Published in: 38, 1, 2021, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2102191
Author(s): Sivakumar Murugadoss, Sybille van den Brule, Frederic Brassinne, Noham Sebaihi, Jorge Mejia, Stéphane Lucas, Jasmine Petry, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet
Published in: Particle and Fibre Toxicology, 17/1, 2020, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-019-0331-3
Author(s): Martens, Marvin; Ammar, Ammar; Riutta, Anders; Waagmeester, Andra; Slenter, Denise N; Hanspers, Kristina; A. Miller, Ryan; Digles, Daniela; Lopes, Elisson N; Ehrhart, Friederike; Dupuis, Lauren J; Winckers, Laurent A; Coort, Susan L; Willighagen, Egon L; Evelo, Chris T; Pico, Alexander R; Kutmon, Martina
Published in: VOLUME=49;ISSUE=D1;STARTPAGE=D613;ENDPAGE=D621;ISSN=0305-1048;TITLE=Nucleic Acids Research, 6, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1024
Author(s): Sivakumar Murugadoss, Lode Godderis, Manosij Ghosh, Peter H. Hoet
Published in: Nanomaterials, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11071793
Author(s): Victoria Xenaki, Mihaela Cuida Marthinussen, Daniela Elena Costea, Andreea Cristiana Didilescu, Cristiano Susin, Mihaela Roxana Cimpan, Anne Nordrehaug Åstrøm
Published in: European Journal of Dental Education, 2019, ISSN 1600-0579
Publisher: Wiley Online Library
Author(s): Peng Zhang,* Zhiling Guo, Zhiyong Zhang,* Hualing Fu, Jason C. White, and Iseult Lynch
Published in: Small, 2020, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202000705
Author(s): Panagiotis Isigonis, Antreas Afantitis, Dalila Antunes, Alena Bartonova, Ali Beitollahi, Nils Bohmer, Evert Bouman, Qasim Chaudhry, Mihaela Roxana Cimpan, Emil Cimpan, Shareen Doak, Damien Dupin, Doreen Fedrigo, Valérie Fessard, Maciej Gromelski, Arno C. Gutleb, Sabina Halappanavar, Peter Hoet, Nina Jeliazkova, Stéphane Jomini, Sabine Lindner, Igor Linkov, Eleonora Marta Longhin, Iseult Lynch, I
Published in: Small, Volume 16, Issue 36, 2020, Page(s) 2003303, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202003303
Author(s): Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena; Breivik, Kyrre; Lie, Stein Atle; Cimpan, Mihaela-Roxana; Åstrøm, Anne-Kristine N
Published in: European Journal of Oral Sciences, 2021, ISSN 1600-0722
Publisher: Wiley
DOI: 10.1111/eos.12821
Author(s): Ammar Ammar; Serena Bonaretti; Laurent A. Winckers; Joris T.K. Quik; Martine Bakker; Dieter Maier; Iseult Lynch; Jeaphianne van Rijn; Egon Willighagen
Published in: Issue 10, 5, 2020, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10102068
Author(s): Yvonne Kohl, Elise Rundén-Pran, Espen Mariussen, Michelle Hesler, Naouale El Yamani, Eleonora Marta Longhin, Maria Dusinska
Published in: Nanomaterials, 2020, ISSN 2079-4991
Publisher: MDPI
Author(s): Iseult Lynch; Antreas Afantitis; Dario Greco; Maria Dusinska; Miguel A. Bañares; Georgia Melagraki
Published in: Nanomaterials, Vol 11, Iss 121, p 121 (2021), 4, 2021, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11010121
Author(s): Alena Kazimirova, Naouale El Yamani, Laura Rubio, Alba García-Rodríguez, Magdalena Barancokova, Ricard Marcos, Maria Dusinska
Published in: Nanomaterials, 10/3, 2020, Page(s) 465, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10030465
Author(s): Ana C. Quevedo; Iseult Lynch; Eugenia Valsami-Jones
Published in: Environmental Science Nano, 1, 2021, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1en00422k
Author(s): Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Published in: 1, 2021
Publisher: seeRRI
DOI: 10.5281/zenodo.5513753
Author(s): Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Published in: 1, 2021
Publisher: EMMC
DOI: 10.5281/zenodo.4701051