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Risk Governance of Nanotechnology

Leistungen

Harmonised SOP for the resuspension of ENMs in biological media and in vitro dosimetry

Harmonised protocol for the resuspension of ENMs in biological media eg cell culturemedium or environmental medium A computational model that allows the prediction of sedimentation over time will be implemented in a guidance document for the accurate dosimetry in submerged in vitro experiments

Consolidated pre-validated guidance document on the determination of ENMs endotoxins content

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties endotoxins content of ENMs

Consolidated pre-validated guidance document on zeta potential determination

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties zeta potential of ENMs

Consolidated pre-validated guidance document on particle counting

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties particle counting of ENMs

End-user training materials for RGC and research community (WP5)

This task will be linked to WP7 and will provide enduser training material to facilitate the generation of anappropriate stakeholder communications toolbox to promote impact and ensure wide dissemination ensuringsustainability of the RiskGONE project outputs The training materials generated will include SOPs for the testsystems that prove to be successful in the roundrobin exercises and webinar content targeted at partners within theconsortium for the Council and also for the scientific community

Draft guidelines regarding the correct implementation of risk transfer in insurance models.

Draft guidelines will also be produced for updating insurance models Currently insurers use outdated models to access risk or none at all If an adverse event occurs this puts them in a poor position to respond proportionally We will first assess those insurance models that exist and their current deployment This will allow us to replicate andwhere appropriate improve upon existing insurance communication lines In this way human and environmental risk indicators can be adopted into a distribution method for underwriters that is both fitforpurpose and is updated with uptodate scientific outputs

Report on feedback on an initial draft of DEB-based AOP for chronic ecotoxicity to ENMs from a workshop at M24

Report on feedback on an initial draft of DEBbased AOP for chronic ecotoxicity to ENMs from a workshopat M24

Report on the expert meeting AOP draft review

Evaluation and definition of AOPs specific for ENM

End-user training materials for RGC and research community (WP6)

This task will be linked to WP7 and will provide enduser training material to facilitate the generation of anappropriate stakeholder communications toolbox to promote impact and ensure wide dissemination ensuringsustainability of the RiskGONE project outputs The training materials generated will include SOPs for the testsystems that prove to be successful in the RR exercises and webinar content targeted at partners within theconsortium for the RG Council and also for the scientific community

Consolidated pre-validated guidance document on effective density

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties effective density of ENMs

Draft guidelines regarding an ethical impact assessment

Draft guidelines for an ethical impact assessment will be produced based on the current guidance given by the CEN Workshop Agreement part 2 CWA 1714522017 E

Draft guidelines regarding the quantification of lifecycle environmental and human health risk indicators

Draft guidelines will be produced for the application of LCA methods to ENMs to include a broader perspective on human and environmental risks with the ENM value chain or life cycle These guidelines will be based on ISO 140402006 and 140442006 environmental management standards for LCA but will highlight particular considerations that should be made when applied to ENMs

Draft guidelines on the societal acceptance of nanomaterials considering risk and benefit perception

Draft guidelines will be produced for analysing the perceptions of risk associated with the use of nanomaterials insociety by developing a sample questionnaire

Report on the final harmonised SOPs used to propose amendments to the existing OECD TGs (WP5)

Following the RR draft guidelines will be prepared as harmonised test methods ensuring that endusers are able to easily apply the tests in their own laboratories The final harmonised SOPs will also be used to propose amendments to the existing OECD TGs both in support of the Malta project phase 2 efforts and also extending the reach of the Malta project contributing to ongoing proposed revisions of ECHAs annexes fornanosubstances under REACH

Consolidated pre-validated guidance document on hydrodynamic diameter and size distribution determination

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties hydrodynamic diameter and size distribution of ENMs

Draft guidelines regarding the quantification of macro-economic benefits

Draft guidelines will be produced for quantifying economic benefits relating to GDP and job growth given the human and environment risk (tasks 3.1, 3.2 and 3.4), from a macro-economic viewpoint. This will include economic approaches such as Willingness-To-Pay, and will show how different regulatory approaches positively/negatively impact the economic opportunities and job creation using a Welfare Economics model.

Mapping, analysis and selection of operating practices of governance bodies

As the NanoReg2 project undertook a mapping exercise of bodies potentially interesting to the RGC, the resulting confidential deliverable will be used as a basis for the work of Task 7.3. Existing data will be carefully checked and updated, if needed, taking into account EU, national and international bodies.

Consolidated pre-validated guidance document on the dispersability of ENMs

Prevalidate methods and guidance documents for the characterisation of physicochemicalproperties dispersability of ENMs

Project website, house style, and social media profiles (Twitter, LinkedIn) finalized

A set of communication tools will help to keep interested partners and stakeholders (public bodies, regulators, civil society, industry, general public, etc.) updated on project developments and results.

Veröffentlichungen

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

Autoren: Sivakumar Murugadoss, Frederic Brassinne, Noham Sebaihi, Jasmine Petry, Stevan M. Cokic, Kirsten L. Van Landuyt, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet, Sybille van den Brule
Veröffentlicht in: Particle and Fibre Toxicology, 17/1, 2020, ISSN 1743-8977
Herausgeber: BioMed Central
DOI: 10.1186/s12989-020-00341-7

Practices and Trends of Machine Learning Application in Nanotoxicology

Autoren: Irini Furxhi, Finbarr Murphy, Martin Mullins, Athanasios Arvanitis, Craig A. Poland
Veröffentlicht in: Nanomaterials, 10/1, 2020, Page(s) 116, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10010116

Thermodynamic Parameters at Bio-Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO2, and TiO2.

Autoren: Aurica Precupas; Daniela Gheorghe; Alina Botea-Petcu; Anca Ruxandra Leonties; Romica Sandu; Vlad Tudor Popa; Espen Mariussen; El Yamani Naouale; Elise Rundén-Pran; Verónica I Dumit; Ying Xue; Mihaela Roxana Cimpan; Maria Dusinska; Andrea Haase; Speranta Tanasescu
Veröffentlicht in: Chemical Research in Toxicology, 1, 2020, ISSN 0893-228X
Herausgeber: American Chemical Society
DOI: 10.1021/acs.chemrestox.9b00468

Reduction of Health Care-Associated Infections (HAIs) with Antimicrobial Inorganic Nanoparticles Incorporated in Medical Textiles: An Economic Assessment

Autoren: Finbarr Murphy, Anat Tchetchik, Irini Furxhi
Veröffentlicht in: Nanomaterials, 10/5, 2020, Page(s) 999, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10050999

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Autoren: Elisabeth Elje, Espen Mariussen, Oscar H. Moriones, Neus G. Bastús, Victor Puntes, Yvonne Kohl, Maria Dusinska, Elise Rundén-Pran
Veröffentlicht in: Nanomaterials, 10/3, 2020, Page(s) 545, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10030545

Embedding Ethical Impact Assessment in Nanosafety Decision Support

Autoren: Ineke Malsch, Panagiotis Isigonis, Maria Dusinska, Evert A. Bouman
Veröffentlicht in: Small, 23 July 2020, 2020, Page(s) 2002901, ISSN 1613-6810
Herausgeber: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202002901

ELIXIR and Toxicology: a community in development

Autoren: Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Veröffentlicht in: F1000Research, 7, 2021, ISSN 2046-1402
Herausgeber: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1

Updating traditional regulatory tests for use with novel materials:Nanomaterial toxicity testing with Daphnia magna

Autoren: Fatima Nasser, Iseult Lynch
Veröffentlicht in: Safety Science, 2019, ISSN 0925-7535
Herausgeber: Elsevier BV

The risk perception of nanotechnology: evidence from twitter

Autoren: Finbarr Murphy, Ainaz Alavi, Martin Mullins, Irini Furxhi,Arash Kiad, Myles Kingston
Veröffentlicht in: RSC Advances, 2022, ISSN 2046-2069
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d1ra09383e

The analytical quest for sub-micron plastics in biological matrices

Autoren: FazelAbdolahpur Monikh, Martina G.Vijver, Denise M.Mitrano, Heather Leslie, Zhiling Guo, Peng Zhang, Iseult Lynch, Eugenia Valsami-Jones, Willie J.G.M. Peijnenburg
Veröffentlicht in: Nanotoday, 2021, ISSN 1748-0132
Herausgeber: Elsevier BV
DOI: 10.1016/j.nantod.2021.101296

A strategy towards the generation of testable adverse outcome pathways for nanomaterials

Autoren: Sivakumar Murugadoss; Ivana Vinković Vrček; Barbara Pem; Karolina Jagiello; Beata Judzinska; Anita Sosnowska; Marvin Martens; Egon Willighagen; Tomasz Puzyn; Maria Dusinska; Mihaela Roxana Cimpan; Valérie Fessard; Peter Hoet
Veröffentlicht in: 38, 1, 2021, ISSN 1868-8551
Herausgeber: Springer Spektrum
DOI: 10.14573/altex.2102191

Is aggregated synthetic amorphous silica toxicologically relevant?

Autoren: Sivakumar Murugadoss, Sybille van den Brule, Frederic Brassinne, Noham Sebaihi, Jorge Mejia, Stéphane Lucas, Jasmine Petry, Lode Godderis, Jan Mast, Dominique Lison, Peter H. Hoet
Veröffentlicht in: Particle and Fibre Toxicology, 17/1, 2020, ISSN 1743-8977
Herausgeber: BioMed Central
DOI: 10.1186/s12989-019-0331-3

WikiPathways: connecting communities.

Autoren: Martens, Marvin; Ammar, Ammar; Riutta, Anders; Waagmeester, Andra; Slenter, Denise N; Hanspers, Kristina; A. Miller, Ryan; Digles, Daniela; Lopes, Elisson N; Ehrhart, Friederike; Dupuis, Lauren J; Winckers, Laurent A; Coort, Susan L; Willighagen, Egon L; Evelo, Chris T; Pico, Alexander R; Kutmon, Martina
Veröffentlicht in: VOLUME=49;ISSUE=D1;STARTPAGE=D613;ENDPAGE=D621;ISSN=0305-1048;TITLE=Nucleic Acids Research, 6, 2021, ISSN 0305-1048
Herausgeber: Oxford University Press
DOI: 10.1093/nar/gkaa1024

Assessing the Toxicological Relevance of NanomaterialAgglomerates and Aggregates Using Realistic Exposure In Vitro

Autoren: Sivakumar Murugadoss, Lode Godderis, Manosij Ghosh, Peter H. Hoet
Veröffentlicht in: Nanomaterials, 2021, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano11071793

Knowledge about nanotechnology and intention to use nanomaterials: A comparative study among dental students in Norway and Romania

Autoren: Victoria Xenaki, Mihaela Cuida Marthinussen, Daniela Elena Costea, Andreea Cristiana Didilescu, Cristiano Susin, Mihaela Roxana Cimpan, Anne Nordrehaug Åstrøm
Veröffentlicht in: European Journal of Dental Education, 2019, ISSN 1600-0579
Herausgeber: Wiley Online Library

Nanomaterial Transformation in the Soil–Plant System: Implications for Food Safety and Application in Agriculture

Autoren: Peng Zhang,* Zhiling Guo, Zhiyong Zhang,* Hualing Fu, Jason C. White, and Iseult Lynch
Veröffentlicht in: Small, 2020, ISSN 1613-6829
Herausgeber: Wiley
DOI: 10.1002/smll.202000705

Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials

Autoren: Panagiotis Isigonis, Antreas Afantitis, Dalila Antunes, Alena Bartonova, Ali Beitollahi, Nils Bohmer, Evert Bouman, Qasim Chaudhry, Mihaela Roxana Cimpan, Emil Cimpan, Shareen Doak, Damien Dupin, Doreen Fedrigo, Valérie Fessard, Maciej Gromelski, Arno C. Gutleb, Sabina Halappanavar, Peter Hoet, Nina Jeliazkova, Stéphane Jomini, Sabine Lindner, Igor Linkov, Eleonora Marta Longhin, Iseult Lynch, I
Veröffentlicht in: Small, Volume 16, Issue 36, 2020, Page(s) 2003303, ISSN 1613-6810
Herausgeber: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202003303

Predicting intention of Norwegian dental health-care workers to use nanomaterials: An application of the augmented theory of planned behavior

Autoren: Xenaki, Victoria; Cuida Marthinussen, Ileana Mihaela; Costea, Daniela Elena; Breivik, Kyrre; Lie, Stein Atle; Cimpan, Mihaela-Roxana; Åstrøm, Anne-Kristine N
Veröffentlicht in: European Journal of Oral Sciences, 2021, ISSN 1600-0722
Herausgeber: Wiley
DOI: 10.1111/eos.12821

A Semi-Automated Workflow for FAIR Maturity Indicators in the Life Sciences.

Autoren: Ammar Ammar; Serena Bonaretti; Laurent A. Winckers; Joris T.K. Quik; Martine Bakker; Dieter Maier; Iseult Lynch; Jeaphianne van Rijn; Egon Willighagen
Veröffentlicht in: Issue 10, 5, 2020, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10102068

Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment-A Review

Autoren: Yvonne Kohl, Elise Rundén-Pran, Espen Mariussen, Michelle Hesler, Naouale El Yamani, Eleonora Marta Longhin, Maria Dusinska
Veröffentlicht in: Nanomaterials, 2020, ISSN 2079-4991
Herausgeber: MDPI

Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance.

Autoren: Iseult Lynch; Antreas Afantitis; Dario Greco; Maria Dusinska; Miguel A. Bañares; Georgia Melagraki
Veröffentlicht in: Nanomaterials, Vol 11, Iss 121, p 121 (2021), 4, 2021, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano11010121

Effects of Titanium Dioxide Nanoparticles on the Hprt Gene Mutations in V79 Hamster Cells

Autoren: Alena Kazimirova, Naouale El Yamani, Laura Rubio, Alba García-Rodríguez, Magdalena Barancokova, Ricard Marcos, Maria Dusinska
Veröffentlicht in: Nanomaterials, 10/3, 2020, Page(s) 465, ISSN 2079-4991
Herausgeber: MDPI
DOI: 10.3390/nano10030465

Cellular repair mechanisms triggered by exposure to silver nanoparticles and ionic silver in embryonic zebrafish cells

Autoren: Ana C. Quevedo; Iseult Lynch; Eugenia Valsami-Jones
Veröffentlicht in: Environmental Science Nano, 1, 2021, ISSN 2051-8161
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d1en00422k

. Fostering regional stakeholder engagement in ethical risk governance of nanomaterials.

Autoren: Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Veröffentlicht in: 1, 2021
Herausgeber: seeRRI
DOI: 10.5281/zenodo.5513753

Exploring User Interest in Ethical Tools for Nano-Risk Governance

Autoren: Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria
Veröffentlicht in: 1, 2021
Herausgeber: EMMC
DOI: 10.5281/zenodo.4701051

Datensätze

NanoReg2 - eNanoMapper database

Autoren: Jeliazkova, Nina; Apostolova, Margarita D.; Andreoli, Cristina; Barone, Flavia; Barrick, Andrew; Battistelli, Chiara; Bossa, Cecilia; Botea-Petcu, Alina; Châtel, Amélie; De Angelis, Isabella; Dusinska, Maria; El Yamani, Naouale; Gheorghe, Daniela; Giusti, Anna; Gómez-Fernández, Paloma; Grafström, Roland; Gromelski, Maciej; Jacobsen, Nicklas Raun; Jeliazkov, Vedrin; Jensen, Keld Alstrup; Kochev, Nikolay; Kohonen, Pekka; Manier, Nicolas; Mariussen, Espen; Mech, Agnieszka; Navas, José María; Paskaleva, Vesselina; Precupas, Aurica; Puzyn, Tomasz; Rasmussen, Kirsten; Ritchie, Peter; Llopis, Isabel Rodríguez; Rundén-Pran, Elise; Sandu, Romica; Shandilya, Neeraj; Tanasescu, Speranta; Haase, Andrea; Nymark, Penny
Veröffentlicht in: Zenodo