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Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Project description

Microorganisms-based production of plant-derived therapeutics

Monoterpenoid indole alkaloids (MIAs) are plant metabolites of a broad diversity, with more than 2 000 of them derived from a common precursor. The anti-cancer drugs irinotecan, vinblastine and vincristine represent some of the few established MIA therapeutics on the market. The ultimate goal of the EU-funded MIAMi project is to develop new tools and methodologies to elucidate the complexity of the biosynthetic pathways in plants and optimise their production in microorganisms. The researchers aim to create pathway-based technologies for the discovery of plant-derived therapeutics and their biosynthesis adapted to genetically traceable and sustainable production hosts. It will allow the refactoring and phenotypical characterisation of >1 000 MIA pathways to scale up production in yeasts. The current goal of the project is to deliver three lead MIA chemicals and 15 MIA analogues.

Call for proposal

H2020-NMBP-BIO-2018-two-stage
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Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 438 313,75

Participants (7)

JOHN INNES CENTRE

Participation ended

United Kingdom
EU contribution
€ 0
Address
Norwich Research Park Colney
NR4 7UH Norwich
Activity type
Research Organisations
UNIVERSITE DE TOURS
France
EU contribution
€ 1 165 125
Address
Rue Du Plat D Etain 60
37020 Tours
Activity type
Higher or Secondary Education Establishments
EXPLORA SRL
Italy
EU contribution
€ 719 250
Address
Via Giacomo Peroni 386
00131 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURE GENOMICS TECHNOLOGIES BV
Netherlands
EU contribution
€ 853 750
Address
Sylviusweg 74
2333 BE Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 341 116,25
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
AXYNTIS
France
EU contribution
€ 619 375
Address
45 Rue De Pommard
75012 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 1 511 371,25
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations