Microorganisms-based production of plant-derived therapeutics
Monoterpenoid indole alkaloids (MIAs) are plant metabolites of a broad diversity, with more than 2 000 of them derived from a common precursor. The anti-cancer drugs irinotecan, vinblastine and vincristine represent some of the few established MIA therapeutics on the market. The ultimate goal of the EU-funded MIAMi project is to develop new tools and methodologies to elucidate the complexity of the biosynthetic pathways in plants and optimise their production in microorganisms. The researchers aim to create pathway-based technologies for the discovery of plant-derived therapeutics and their biosynthesis adapted to genetically traceable and sustainable production hosts. It will allow the refactoring and phenotypical characterisation of >1 000 MIA pathways to scale up production in yeasts. The current goal of the project is to deliver three lead MIA chemicals and 15 MIA analogues.
Fields of science
Call for proposal
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Funding SchemeRIA - Research and Innovation action
2333 BE Leiden