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Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Project description

Microorganisms-based production of plant-derived therapeutics

Monoterpenoid indole alkaloids (MIAs) are plant metabolites of a broad diversity, with more than 2 000 of them derived from a common precursor. The anti-cancer drugs irinotecan, vinblastine and vincristine represent some of the few established MIA therapeutics on the market. The ultimate goal of the EU-funded MIAMi project is to develop new tools and methodologies to elucidate the complexity of the biosynthetic pathways in plants and optimise their production in microorganisms. The researchers aim to create pathway-based technologies for the discovery of plant-derived therapeutics and their biosynthesis adapted to genetically traceable and sustainable production hosts. It will allow the refactoring and phenotypical characterisation of >1 000 MIA pathways to scale up production in yeasts. The current goal of the project is to deliver three lead MIA chemicals and 15 MIA analogues.

Call for proposal

H2020-NMBP-TR-IND-2018-2020

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Sub call

H2020-NMBP-BIO-2018-two-stage

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Net EU contribution
€ 1 478 313,75
Address
Anker Engelunds Vej 101
2800 Kongens Lyngby
Denmark

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (7)

JOHN INNES CENTRE

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Norwich Research Park Colney
NR4 7UH Norwich
Region
East of England East Anglia Breckland and South Norfolk
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITE DE TOURS
France
Net EU contribution
€ 1 275 125,00
Address
Rue Du Plat D Etain 60
37020 Tours

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Region
Centre — Val de Loire Centre — Val de Loire Indre-et-Loire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EXPLORA SRL
Italy
Net EU contribution
€ 719 250,00
Address
Via Giacomo Peroni 386
00131 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FUTURE GENOMICS TECHNOLOGIES BV
Netherlands
Net EU contribution
€ 853 750,00
Address
Sylviusweg 74
2333 BE Leiden

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 341 116,25
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
AXYNTIS
France
Net EU contribution
€ 619 375,00
Address
198 Avenue De France
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 1 361 371,25
Address
Hofgartenstrasse 8
80539 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00