Skip to main content

Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Project description

Microorganisms-based production of plant-derived therapeutics

Monoterpenoid indole alkaloids (MIAs) are plant metabolites of a broad diversity, with more than 2 000 of them derived from a common precursor. The anti-cancer drugs irinotecan, vinblastine and vincristine represent some of the few established MIA therapeutics on the market. The ultimate goal of the EU-funded MIAMi project is to develop new tools and methodologies to elucidate the complexity of the biosynthetic pathways in plants and optimise their production in microorganisms. The researchers aim to create pathway-based technologies for the discovery of plant-derived therapeutics and their biosynthesis adapted to genetically traceable and sustainable production hosts. It will allow the refactoring and phenotypical characterisation of >1 000 MIA pathways to scale up production in yeasts. The current goal of the project is to deliver three lead MIA chemicals and 15 MIA analogues.

Call for proposal

H2020-NMBP-TR-IND-2018-2020

See other projects for this call

Sub call

H2020-NMBP-BIO-2018-two-stage

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Net EU contribution
€ 1 438 313,75
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (7)

JOHN INNES CENTRE

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Norwich Research Park Colney
NR4 7UH Norwich
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
East of England East Anglia Breckland and South Norfolk
UNIVERSITE DE TOURS
France
Net EU contribution
€ 1 165 125,00
Address
Rue Du Plat D Etain 60
37020 Tours
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Centre — Val de Loire Centre — Val de Loire Indre-et-Loire
EXPLORA SRL
Italy
Net EU contribution
€ 719 250,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Via Giacomo Peroni 386
00131 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUTURE GENOMICS TECHNOLOGIES BV
Netherlands
Net EU contribution
€ 853 750,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Sylviusweg 74
2333 BE Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 341 116,25
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AXYNTIS
France
Net EU contribution
€ 619 375,00
Address
45 Rue De Pommard
75012 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Paris
 
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 1 511 371,25
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Non-EU contribution
€ 0,00