Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Deliverables

Websites, patent fillings, videos etc. (6)

Periodic newsletters (M12)

Periodic newsletters

Validated growth-coupled methyl-transferase system for 1 MIA compound

Validated growth-coupled methyl-transferase system for 1 MIA compound

Expression atlas

Expression atlas

Annotated reference genome of Rauvolfia tetraphylla

Annotated reference genome of Rauvolfia tetraphylla

Project website: the report will provide a functional description of the project website and its main sections.

Project website: the report will provide a functional description of the project website and its main sections.

Press release about the launching of MIAMi project will be sent to the media to disseminate the project

Press release about the launching of MIAMi project will be sent to the media to disseminate the project

Documents, reports (3)

List of identified metabolites (and corresponding accurate masses) in Rauvolfia serpentina and Rauvolfia tetraphylla plants

List of identified metabolites (and corresponding accurate masses) in Rauvolfia serpentina and Rauvolfia tetraphylla plants

Publicly available SOPs

Publicly available SOPs

Sample preparation methods for MSI studies of various parts of the Rauvolfia serpentina and Rauvolfia tetraphylla plants

Sample preparation methods for MSI studies of various parts of the Rauvolfia serpentina and Rauvolfia tetraphylla plants

Open Research Data Pilot (1)

First version of data management plan as required by Open Research Data Pilot

First version of data management plan as required by Open Research Data Pilot

Publications

Peer reviewed articles (6)

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Author(s): Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Published in: Trends in Pharmacological Sciences, 2020, ISSN 0165-6147
DOI: 10.1016/j.tips.2019.12.006

Evolution-guided engineering of small-molecule biosensors

Author(s): Tim Snoek, Evan K Chaberski, Francesca Ambri, Stefan Kol, Sara P Bjørn, Bo Pang, Jesus F Barajas, Ditte H Welner, Michael K Jensen, Jay D Keasling
Published in: Nucleic Acids Research, Issue 48/1, 2019, Page(s) e3-e3, ISSN 0305-1048
DOI: 10.1093/nar/gkz954

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

Author(s): Ines Carqueijeiro, Chloe Langley, Dagny Grzech, Konstantinos Koudounas, Nicolas Papon, Sarah E O’Connor, Vincent Courdavault
Published in: Current Opinion in Biotechnology, Issue 65, 2020, Page(s) 17-24, ISSN 0958-1669
DOI: 10.1016/j.copbio.2019.11.017

Towards the Microbial Production of Plant-Derived Anticancer Drugs

Author(s): Vincent Courdavault, Sarah E. O’Connor, Audrey Oudin, Sébastien Besseau, Nicolas Papon
Published in: Trends in Cancer, Issue 6/6, 2020, Page(s) 444-448, ISSN 2405-8033
DOI: 10.1016/j.trecan.2020.02.004

Virus-Induced Gene Silencing: Hush Genes to Make Them Talk

Author(s): Vincent Courdavault, Sébastien Besseau, Audrey Oudin, Nicolas Papon, Sarah Ellen O’Connor
Published in: Trends in Plant Science, Issue 25/7, 2020, Page(s) 714-715, ISSN 1360-1385
DOI: 10.1016/j.tplants.2020.02.013

Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes

Author(s): Bettina Lengger, Michael K Jensen
Published in: FEMS Yeast Research, Issue 20/1, 2020, ISSN 1567-1356
DOI: 10.1093/femsyr/foz087