Project description DEENESFRITPL It takes a (microbial) village One of the reasons fruits, vegetables and whole grains help protect us against non-communicable diseases, such as heart disease, diabetes and cancer, has to do with plant metabolism. Flavonoids are secondary metabolites produced by many plants that help them combat oxidative stress and act as growth regulators. They have antioxidant and anti-inflammatory properties in people. Despite the tremendous interest in flavonoids, their industrial production is currently immature. In nature, they are produced via complex physical and chemical pathways involving trafficking of chemicals throughout plant compartments. To better mimic this and even open the door to the production of flavonoids not seen in nature, the EU-funded SynBio4Flav project is developing synthetic microbial communities with members genetically programmed to execute specific steps in the complex biosynthetic pathways. Show the project objective Hide the project objective Objective This Project pursues the implementation a standardized pipeline for surrogate production of plant flavonoids in synthetic microbial consortia (SMCs) by means of standardization and systems-guided assembly of highly complex biological devices. Flavonoids are the more abundant and consumed group of phytonutrients, used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite its growing demand, flavonoids production remains elusive to chemical synthesis and biotech-based approaches, thus current flavonoid market is constrained to the scarce plant-based sources. These compounds are synthetized in nature through complex pathways involving an intense chemicals trafficking through plant compartments. By facilitating component troubleshooting and re-usability—instead of optimizing a single whole-cell biocatalyst— SynBio4Flav will recreate such non-homogeneous scenario by breaking-down specific portions of the complexes and highly regulated biochemical routes between different microbial species, each of them genetically programmed to deliver an optimal output of the corresponding biosynthetic step(s) i.e. through a distributed catalysis engineered in a defined SMC. Enabling such novel approach, SynBio4Flav will push the existing boundaries of the synthetic biology by acting along the whole Synthetic Biology hierarchy abstraction, and remarkably, in those with high complexity level e.g. cell systems and microbial communities. By creating libraries of optimized cell systems programmed to deliver an optimal output, and novel synthetic biology tools for cell systems assembling into 3D SMCs, SysBio4Flav will reach a TRL5 in production of natural and new-to-nature glycosylated flavonoids. The durable output of SynBio4Flav will be a standardized platform containing hundreds of optimal cell systems for exploring the full combinatorial space of flavonoids biosynthesis, including thousands of new-to-nature analogues. Fields of science engineering and technologyother engineering and technologiesfood technologynatural sciencesbiological sciencessynthetic biologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencescatalysisbiocatalysis Keywords Synthetic Biology Systems Biology Systems Biotechnology Synthetic Microbial Consortia Distributed Catalysis Functionalized Flavonoids P. putida E. coli S. Albus S. cerevisiae Programme(s) H2020-EU.2.1.4. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology Main Programme Topic(s) BIOTEC-03-2018 - Synthetic biology to expand diversity of nature's chemical production (RIA) Call for proposal H2020-NMBP-TR-IND-2018-2020 See other projects for this call Sub call H2020-NMBP-BIO-2018-two-stage Funding Scheme RIA - Research and Innovation action Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Net EU contribution € 1 704 071,25 Address Calle serrano 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CHALMERS TEKNISKA HOGSKOLA AB Sweden Net EU contribution € 1 206 128,75 Address - 412 96 Goteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE Germany Net EU contribution € 552 987,50 Address Arthur-scheunert-allee 114-116 14558 Nuthetal See on map Region Brandenburg Brandenburg Potsdam-Mittelmark Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIWERSYTET PRZYRODNICZY WE WROCLAWIU Poland Net EU contribution € 528 110,00 Address Ul. cypriana kamila norwida 25 50-375 Wroclaw See on map Region Makroregion południowo-zachodni Dolnośląskie Miasto Wrocław Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET GREIFSWALD Germany Net EU contribution € 706 250,00 Address Domstrasse 11 17489 Greifswald See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD DE OVIEDO Spain Net EU contribution € 628 985,00 Address Calle san francisco 3 33003 Oviedo See on map Region Noroeste Principado de Asturias Asturias Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EXTRASYNTHESE SAS France Net EU contribution € 270 208,75 Address Impasse jacquard zi lyon nord 69730 Genay See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BIOPOLIS SL Spain Net EU contribution € 614 752,50 Address Calle catedratico agustin escardino benlloch 9 parque cientifico de la universidad de valencia 46980 Paterna valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EXPLORA SRL Italy Net EU contribution € 566 666,25 Address Via giacomo peroni 386 00131 Roma See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SYMRISE AG Germany Net EU contribution € 268 512,50 Address Muhlenfeldstrasse 1 37603 Holzminden See on map Region Niedersachsen Hannover Holzminden Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LIQUIFER SYSTEMS GROUP GMBH Austria Net EU contribution € 324 378,75 Address Obere donaustrasse 97-99 1 62 1020 Vienna See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00