Apoptotic foci: composition, structure and dynamics

Project Information

APOSITE

Grant agreement ID: 817758

DOI

10.3030/817758

Project closed

EC signature date 18 February 2019

Start date 1 April 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITAT ZU KOLN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Modulation of Mitochondria–Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model

Author(s): Mikel Etxebeste-Mitxeltorena, Hector Flores-Romero, Sandra Ramos-Inza, Esther Masiá, Maria Nenchova, Jorge Montesinos, Loreto Martinez-Gonzalez, Gracia Porras, Mar Orzáez, María J. Vicent, Carmen Gil, Estela Area-Gomez, Ana J. Garcia-Saez, Ana Martinez
Published in: Journal of Medicinal Chemistry, Issue 68, 2025, Page(s) 1179-1194, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c01368

Pore formation in regulated cell death

Author(s): Hector Flores‐Romero, Uris Ros, Ana J Garcia‐Saez
Published in: The EMBO Journal, Issue 39/23, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105753

BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

Author(s): Hector Flores‐Romero; Lisa Hohorst; Malina John; Marie‐Christine Albert; Louise E King; Laura Beckmann; Tamas Szabo; Vanessa Hertlein; Xu Luo; Andreas Villunger; Lukas P Frenzel; Hamid Kashkar; Ana J Garcia‐Saez
Published in: The EMBO Journal, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108690

Activator of apoptosis harakiri ( <scp>HRK</scp> ) localisation at mitochondria alters mitochondrial morphology independently of other <scp>BCL</scp> ‐2 proteins

Author(s): Louise E. King, Lukas Faber, Ana J. García‐Sáez
Published in: The FEBS Journal, 2025, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.70255

Apoptosis regulation at the mitochondria membrane level

Author(s): Shashank Dadsena, Louise E. King, Ana J. García-Sáez
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Issue 1863/12, 2021, Page(s) 183716, ISSN 0005-2736
Publisher: Elsevier BV
DOI: 10.1016/j.bbamem.2021.183716

The Mysteries around the BCL-2 Family Member BOK

Author(s): Raed Shalaby, Hector Flores-Romero, Ana J. García-Sáez
Published in: Biomolecules, Issue 10/12, 2020, Page(s) 1638, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10121638

DRP1 interacts directly with BAX to induce its activation and apoptosis

Author(s): Andreas Jenner; Aida Peña‐Blanco; Raquel Salvador‐Gallego; Begoña Ugarte‐Uribe; Cristiana Zollo; Tariq Ganief; Jan Bierlmeier; Markus Mund; Jason E Lee; Jonas Ries; Dirk Schwarzer; Boris Macek; Ana J Garcia‐Saez
Published in: The EMBO Journal, Issue 1, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108587

MLKL activity requires a splicing-regulated, druggable intramolecular interaction

Author(s): Uris Ros, Veronica Martinez-Osorio, Pedro A. Valiente, Yasmin Abdelwahab, Milos Gojkovic, Raed Shalaby, Silvia Zanna, Julia Saggau, Laurens Wachsmuth, Harshal N. Nemade, Jonathan Zoeller, Hannah Lottermoser, Yu-Guang Chen, Mohamed Ibrahim, Konstantinos Kelepouras, Lazaros Vasilikos, Paula Bedoya, Rafael A. Espiritu, Stefan Müller, Veronika Altmannova, D. Peter Tieleman, John Weir, Julian Langer,
Published in: Molecular Cell, Issue 85, 2025, Page(s) 1589-1605.e12, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2025.03.015

Lipid unsaturation promotes BAX and BAK pore activity during apoptosis

Author(s): Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N. Melo, Ana J. García-Sáez
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-49067-6

Techniques for studying membrane pores

Author(s): Uris Ros, Lohans Pedrera, Ana J. Garcia-Saez
Published in: Current Opinion in Structural Biology, Issue 69, 2021, Page(s) 108-116, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2021.03.012

The Incomplete Puzzle of the BCL2 Proteins

Author(s): Flores-Romero, García-Sáez
Published in: Cells, Issue 8/10, 2019, Page(s) 1176, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8101176

Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods

Author(s): Janine Rieger; Michael Fitz; Stefan Markus Fischer; Niklas Wallmeroth; Hector Flores-Romero; Nina Monika Fischer; Luise Helene Brand; Ana J. García-Sáez; Kenneth Wayne Berendzen; Virtudes Mira-Rodado
Published in: Genes; Volume 14; Issue 8; Pages: 1638, 2023, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14081638

Mitochondrial dynamics and pore formation in regulated cell death pathways

Author(s): Lisa Hohorst, Uris Ros, Ana J. Garcia-Saez
Published in: Trends in Biochemical Sciences, Issue 50, 2025, Page(s) 1001-1014, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2025.09.001

Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation

Author(s): Raed Shalaby, Arzoo Diwan, Hector Flores-Romero, Vanessa Hertlein, Ana J. Garcia-Saez
Published in: Cell Death &amp; Differentiation, Issue 30, 2023, Page(s) 731-741, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-022-01078-w

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

Author(s): Katia Cosentino; Vanessa Hertlein; Andreas Jenner; Timo Dellmann; Milos Gojkovic; Aida Peña-Blanco; Shashank Dadsena; Noel Wajngarten; John S.H. Danial; Jervis Vermal Thevathasan; Markus Mund; Jonas Ries; Ana J. Garcia-Saez
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.01.008

Mitochondrial pores at the crossroad between cell death and inflammatory signaling

Author(s): Hector Flores-Romero, Shashank Dadsena, Ana J. García-Sáez
Published in: Molecular Cell, Issue 83, 2025, Page(s) 843-856, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.02.021

Other (1)

Mechanical forces drive mitochondrial matrix extrusion and apoptotic pore growth

Author(s): Andreas Jenner, Timo Dellmann, Hyuntae Kim, David Gomez, Cristiana Zollo, Jürgen Köfinger, Katrin Seidel, Felix Gaedke, Astrid Schauss, Gerhard Hummer, Ana J. Garcia-Saez
Published in: Biorxiv preprint, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.12.653510