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Apoptotic foci: composition, structure and dynamics

Project description

Role of apoptotic foci in mitochondrial outer membrane permeabilisation

Apoptotic cell death regulation is essential for development, immune function and tissue homeostasis. Mitochondrial outer membrane permeabilisation (MOMP) is central for apoptosis execution, and understanding the mechanisms mediating MOMP is crucial for the potential clinical application of apoptosis. Recent studies from the host laboratory found that Bax and Bak protein dimers assemble at specific apoptotic foci to mediate MOMP. The EU-funded APOSITE project will investigate the composition, dynamics and structure of apoptotic foci to elucidate their integral role in apoptosis regulation. Researchers will capitalise on their expertise in cell death and advanced imaging technologies. The multidisciplinary approach promises to solve the question of how Bax and Bak mediate MOMP and to help develop apoptosis modulators for medical applications.

Host institution

UNIVERSITAT ZU KOLN
Net EU contribution
€ 1 910 421,92
Address
Albertus Magnus Platz
50931 Koln
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 910 421,92

Beneficiaries (2)

UNIVERSITAT ZU KOLN
Germany
Net EU contribution
€ 1 910 421,92
Address
Albertus Magnus Platz
50931 Koln

See on map

Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 910 421,92
EBERHARD KARLS UNIVERSITAET TUEBINGEN

Participation ended

Germany
Net EU contribution
€ 89 578,08
Address
Geschwister-scholl-platz
72074 Tuebingen
Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 89 578,08