Role of apoptotic foci in mitochondrial outer membrane permeabilisation
Apoptotic cell death regulation is essential for development, immune function and tissue homeostasis. Mitochondrial outer membrane permeabilisation (MOMP) is central for apoptosis execution, and understanding the mechanisms mediating MOMP is crucial for the potential clinical application of apoptosis. Recent studies from the host laboratory found that Bax and Bak protein dimers assemble at specific apoptotic foci to mediate MOMP. The EU-funded APOSITE project will investigate the composition, dynamics and structure of apoptotic foci to elucidate their integral role in apoptosis regulation. Researchers will capitalise on their expertise in cell death and advanced imaging technologies. The multidisciplinary approach promises to solve the question of how Bax and Bak mediate MOMP and to help develop apoptosis modulators for medical applications.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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