Mechanisms of chromatin organization and reprogramming in totipotent mammalian zygotes

Project Information

TotipotentZygotChrom

Grant agreement ID: 818556

DOI

10.3030/818556

Project closed

EC signature date 18 February 2019

Start date 1 February 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Book chapters (1)

CUT&Tag for Transcription Factor Binding Profiles During Mammalian Zygotic Genome Activation

Author(s): Wataru Kobayashi, Kikuë Tachibana
Published in: Methods in Molecular Biology, Zygotic Genome Activation, 2025, Page(s) 77-87
Publisher: Springer US
DOI: 10.1007/978-1-0716-4522-2_6

Peer reviewed articles (9)

MCM complexes are barriers that restrict cohesin-mediated loop extrusion.

Author(s): Dequeker, B.J.H., Scherr, M.J., Brandao, H.B., Gassler, J., Powell, S., Gaspar, I., Flyamer, I.M., Lalic, A., Tang, W., Stocsits, R., Davidson, I.F., Peters, J.-M, Duderstadt, K.E., Mirny, L.A., Tachibana, K.
Published in: Nature, Issue 606/7912, 2022, Page(s) 197-203, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04730-0

Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by minor groove anchor competition

Author(s): Wataru Kobayashi, Anna Sappler, Daniel Bollschweiler, Maximilian Kümmecke, Jérôme Basquin, Eda Nur Arslantas, Siwat Ruangroengkulrith, Renate Hornberger, Karl Duderstadt, Kikuë Tachibana
Published in: Nature Structural & Molecular Biology, Issue 31, 2024, Page(s) 757-766, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1101/2023.06.14.544949

Zygotic genome activation by the totipotency pioneer factor Nr5a2.

Author(s): Gassler, J., Kobayashi, W., Gáspár, I., Ruangroengkulrith, S., Mohanan, A., Gómez Hernández, L., Kravchenko, P., Kümmecke, M., Lalic, A., Rifel, N., Ashburn, R., Zaczek, M., Vallot, A., Cuenca Rico, L., Ladstätter, S., Tachibana, K.
Published in: Science, Issue 378/6626, 2022, Page(s) 1305-1315, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn7478

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development

Author(s): Wataru Kobayashi, Siwat Ruangroengkulrith, Eda Nur Arslantas, Adarsh Mohanan, Kikuë Tachibana
Published in: Development, Issue 153, 2026, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.205059

Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation

Author(s): Pavel Kravchenko, Kikuë Tachibana
Published in: Nature Reviews Molecular Cell Biology, Issue 26, 2024, Page(s) 68-79, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-024-00772-6

Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age

Author(s): Emmanouella E. Chatzidaki, Sean Powell, Bart J.H. Dequeker, Johanna Gassler, Mariana C.C. Silva, Kikuë Tachibana
Published in: Current Biology, Issue 31/18, 2021, Page(s) 4038-4051.e7, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.06.076

Genome folding and zygotic genome activation in mammalian preimplantation embryos

Author(s): Anastasiia Bondarieva, Kikuë Tachibana
Published in: Current Opinion in Genetics & Development, Issue 89, 2024, Page(s) 102268, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2024.102268

Awakening of the zygotic genome by pioneer transcription factors.

Author(s): Kobayashi, W., Tachibana, K.
Published in: Current Opinion in Structural Biology, Issue 71, 2021, Page(s) 94-100, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2021.05.013

Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination

Author(s): Wataru Kobayashi, Alicia K. Michael, Siwat Ruangroengkulrith, Maximilian Kümmecke, Kikuë Tachibana
Published in: STAR Protocols, Issue 7, 2026, Page(s) 104295, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2025.104295