Mechanisms of chromatin organization and reprogramming in totipotent mammalian zygotes

Project Information

TotipotentZygotChrom

Grant agreement ID: 818556

DOI

10.3030/818556

EC signature date 18 February 2019

Start date 1 February 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

MCM complexes are barriers that restrict cohesin-mediated loop extrusion.

Author(s): Dequeker, B.J.H., Scherr, M.J., Brandao, H.B., Gassler, J., Powell, S., Gaspar, I., Flyamer, I.M., Lalic, A., Tang, W., Stocsits, R., Davidson, I.F., Peters, J.-M, Duderstadt, K.E., Mirny, L.A., Tachibana, K.
Published in: Nature, Issue 606/7912, 2022, Page(s) 197-203, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04730-0

Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by minor groove anchor competition

Author(s): Wataru Kobayashi, Anna Sappler, Daniel Bollschweiler, Maximilian Kümmecke, Jérôme Basquin, Eda Nur Arslantas, Siwat Ruangroengkulrith, Renate Hornberger, Karl Duderstadt, Kikuë Tachibana
Published in: Nature Structural & Molecular Biology, Issue 31, 2024, Page(s) 757-766, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1101/2023.06.14.544949

Zygotic genome activation by the totipotency pioneer factor Nr5a2.

Author(s): Gassler, J., Kobayashi, W., Gáspár, I., Ruangroengkulrith, S., Mohanan, A., Gómez Hernández, L., Kravchenko, P., Kümmecke, M., Lalic, A., Rifel, N., Ashburn, R., Zaczek, M., Vallot, A., Cuenca Rico, L., Ladstätter, S., Tachibana, K.
Published in: Science, Issue 378/6626, 2022, Page(s) 1305-1315, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn7478

Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation

Author(s): Pavel Kravchenko, Kikuë Tachibana
Published in: Nature Reviews Molecular Cell Biology, Issue 26, 2024, Page(s) 68-79, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-024-00772-6

Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age

Author(s): Emmanouella E. Chatzidaki, Sean Powell, Bart J.H. Dequeker, Johanna Gassler, Mariana C.C. Silva, Kikuë Tachibana
Published in: Current Biology, Issue 31/18, 2021, Page(s) 4038-4051.e7, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.06.076

Genome folding and zygotic genome activation in mammalian preimplantation embryos

Author(s): Anastasiia Bondarieva, Kikuë Tachibana
Published in: Current Opinion in Genetics & Development, Issue 89, 2024, Page(s) 102268, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2024.102268

Awakening of the zygotic genome by pioneer transcription factors.

Author(s): Kobayashi, W., Tachibana, K.
Published in: Current Opinion in Structural Biology, Issue 71, 2021, Page(s) 94-100, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2021.05.013