Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits

Project Information

CancerADAPT

Grant agreement ID: 819242

DOI

10.3030/819242

EC signature date 30 April 2019

Start date 1 November 2019

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 882,00

EU contribution

€ 1 999 882,00

Coordinated by

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

Author(s): Javier Plou; Pablo S. Valera; Isabel García; Carlos D. L. de Albuquerque; Arkaitz Carracedo; Luis M. Liz-Marzán
Published in: ACS Photonics, Issue Vol. 9, Nº 2, 2022, Page(s) 333–350, ISSN 2330-4022
Publisher: American Chemical Society
DOI: 10.1021/acsphotonics.1c01934

1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Author(s): Bruzzone, Chiara; Loizaga-Iriarte, Ana; Sánchez-Mosquera, Pilar; Gil-Redondo, Rubén; Astobiza, Ianire; Diercks, Tammo; Cortazar, Ana R; Ugalde-Olano, Aitziber; Schäfer, Hartmut; Blanco, Francisco J; Unda, Miguel; Cannet, Claire; Spraul, Manfred; Mato, José M; Embade, Nieves; Carracedo, Arkaitz; Millet, Oscar
Published in: Journal of proteome, Issue 2, 2020, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00091

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

Author(s): Laura Bozal-Basterra, María Gonzalez-Santamarta, Veronica Muratore, Aitor Bermejo-Arteagabeitia, Carolina Da Fonseca, Orhi Barroso-Gomila, Mikel Azkargorta, Ibon Iloro, Olatz Pampliega, Ricardo Andrade, Natalia Martín-Martín, Tess C Branon, Alice Y Ting, Jose A Rodríguez, Arkaitz Carracedo, Felix Elortza, James D Sutherland, Rosa Barrio
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55957

Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy.

Author(s): Javier Plou; Beatriz Molina-Martínez; Clara García-Astrain; Judith Langer; Isabel García; Amaia Ercilla; Govindaraj Perumal; Arkaitz Carracedo; Luis M. Liz-Marzán
Published in: Nano Letters, Issue 21, 2021, Page(s) 8785−8793, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c03070

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Author(s): Parastoo Shahrouzi, Ianire Astobiza, Ana R. Cortazar, Verónica Torrano, Alice Macchia, Juana M. Flores, Chiara Niespolo, Isabel Mendizabal, Ruben Caloto, Amaia Ercilla, Laura Camacho, Leire Arreal, Maider Bizkarguenaga, Maria L. Martinez-Chantar, Xose R. Bustelo, Edurne Berra, Endre Kiss-Toth, Guillermo Velasco, Amaia Zabala-Letona, Arkaitz Carracedo
Published in: Cancers, Issue 12/9, 2020, Page(s) 2593, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092593

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Author(s): Ivana Hermanova, Patricia Zúñiga-García, Alfredo Caro-Maldonado, Sonia Fernandez-Ruiz, Fernando Salvador, Natalia Martín-Martín, Amaia Zabala-Letona, Marc Nuñez-Olle, Verónica Torrano, Laura Camacho, Jose M. Lizcano, Ana Talamillo, Suzanne Carreira, Bora Gurel, Ana R. Cortazar, Marc Guiu, Jose I. López, Anabel Martinez-Romero, Ianire Astobiza, Lorea Valcarcel-Jimenez, Mar Lorente, Amaia Ar
Published in: Journal of Experimental Medicine, Issue 217/6, 2020, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20191787

Machine Learning‐Assisted High‐Throughput SERS Classification of Cell Secretomes

Author(s): Javier Plou; Pablo S. Valera; Isabel García; David Vila‐Liarte; Carlos Renero‐Lecuna; Jesús Ruiz‐Cabello; Arkaitz Carracedo; Luis M. Liz‐Marzán
Published in: instname:Universidade de Vigo (UVigo), Issue 1, 2023, Page(s) 2207658, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202207658

CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets

Author(s): Rubén Caloto; L. Francisco Lorenzo-Martín; Víctor Quesada; Arkaitz Carracedo; Xosé R. Bustelo
Published in: instname:Universidad de Oviedo (UNIOVI), Issue 2, 2022, Page(s) 1411, ISSN 2079-7737
Publisher: MPDI BIOLOGY
DOI: 10.3390/biology11101411

Identification of proximal SUMO-dependent interactors using SUMO-ID

Author(s): Orhi Barroso-Gomila; Fredrik Trulsson; Veronica Muratore; Iñigo Canosa; Laura Merino-Cacho; Ana R. Cortazar; Coralia Pérez; Mikel Azkargorta; Ibon Iloro; Arkaitz Carracedo; Ana M. Aransay; Felix Elortza; Ugo Mayor; Ugo Mayor; Alfred C.O. Vertegaal; Rosa Barrio; James D. Sutherland
Published in: Nature Communications, Issue 2, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26807-6

Angiocrine polyamine production regulates adiposity

Author(s): Monelli, E.; Villacampa, P.; Zabala-Letona, A.; Martinez-Romero, A.; Llena, J.; Beiroa, D.; Gouveia, L.; Chivite, I.; Zagmutt, S.; Gama-Perez, P.; Osorio-Conles, O.; Muixi, L.; Martinez-Gonzalez, A.; Castillo, S.D.; Martin-Martin, N.; Castel, P.; Valcarcel-Jimenez, L.; Garcia-Gonzalez, I.; Villena, J.A.; Fernandez-Ruiz, S.; Serra, D.; Herrero, L.; Benedito, R.; Garcia-Roves, P.; Vidal, J.; Cohen,
Published in: Nature metabolism, Issue Vol. 4, Nº 3, 2022, Page(s) 327 - 343, ISSN 2522-5812
Publisher: Nature Research
DOI: 10.1038/s42255-022-00544-6

Implication of Ceramide Kinase/C1P in Cancer Development and Progression

Author(s): Camacho, L.; Ouro, A.; Gomez-Larrauri, A.; Carracedo, A.; Gomez-Muñoz, A.
Published in: Cancers (Basel), Issue 1, 2022, Page(s) 227, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010227

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author(s): García-Vílchez, Raquel; Añazco-Guenkova, Ana; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D’ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizabal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde
Published in: https://hal.univ-lorraine.fr/hal-04187091, Issue 2, 2023, Page(s) 22:119, ISSN 1476-4598
Publisher: BioMed Central
DOI: 10.1186/s12943-023-01809-8

The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer.

Author(s): Carla Solé; Ibai Goicoechea; Alai Goñi; Maike Schramm; María Armesto; María Arestin; Lorea Manterola; Maitena Tellaetxe; Aitor Alberdi; Leonor Nogueira; Mathieu Roumiguié; José I. López; Juan Pablo Sanz Jaka; Ander Urruticoechea; Itziar Vergara; Ana Loizaga-Iriarte; Miguel Unda; Arkaitz Carracedo; Bernard Malavaud; Charles H. Lawrie; Charles H. Lawrie
Published in: Cancers, Issue 1, 2020, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12020513

Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens.

Author(s): Laura Camacho; Amaia Zabala-Letona; Ana R. Cortazar; Ianire Astobiza; Asier Dominguez-Herrera; Amaia Ercilla; Jana Crespo; Cristina Viera; Sonia Fernández-Ruiz; Ainara Martinez-Gonzalez; Verónica Torrano; Natalia Martín-Martín; Antonio Gómez-Muñoz; Arkaitz Carracedo
Published in: Volume 13, Issue 3, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13174307

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Author(s): Angela M. Araujo; Andrea Abaurrea; Peio Azcoaga; Joanna I. López-Velazco; Sara Manzano; Javier Rodriguez; Ricardo Rezola; Leire Egia-Mendikute; Fátima Valdés-Mora; Juana M. Flores; Liam Jenkins; Laura Pulido; Iñaki Osorio-Querejeta; Patricia Fernández-Nogueira; Nicola Ferrari; Cristina Viera; Natalia Martín-Martín; Alexandar Tzankov; Serenella Eppenberger-Castori; Isabel Alvarez-Lopez; Ande
Published in: Journal of Clinical Investigation, Issue Vol. 32, Nº 7, 2022, Page(s) e148667, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci148667

Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media

Author(s): Javier Plou, Isabel García, Mathias Charconnet, Ianire Astobiza, Clara García‐Astrain, Cristiano Matricardi, Agustín Mihi, Arkaitz Carracedo, Luis M. Liz‐Marzán
Published in: Advanced Functional Materials, Issue 30/17, 2020, Page(s) 1910335, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201910335

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Author(s): Amaia Zabala-Letona; Amaia Arruabarrena-Aristorena; Sonia Fernandez-Ruiz; Cristina Viera; Onintza Carlevaris; Amaia Ercilla; Isabel Mendizabal; Teresa Martin; Alice Macchia; Laura Camacho; Mikel Pujana-Vaquerizo; Pilar Sanchez-Mosquera; Verónica Torrano; Natalia Martin-Martin; Patricia Zuniga-Garcia; Mireia Castillo-Martin; Aitziber Ugalde-Olano; Ana Loizaga-Iriarte; Miguel Unda; Jose M. Mato; Ed
Published in: Oncogenesis, Issue 1, 2022, ISSN 2157-9024
Publisher: Nature Publishing Group
DOI: 10.1038/s41389-022-00382-x

LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton

Author(s): Laura Bozal-Basterra, María Gonzalez-Santamarta, Veronica Muratore, Natalia Martín-Martín, Amaia Ercilla, Jose A. Rodríguez, Arkaitz Carracedo, James D. Sutherland, Rosa Barrio
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Front Cell Dev Biol
DOI: 10.3389/fcell.2021.624089

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Author(s): Rubén Rodríguez-Agudo,Naroa Goikoetxea-Usandizaga,Marina Serrano-Maciá,Pablo Fernández-Tussy, David Fernández-Ramos, Sofía Lachiondo-Ortega, Irene González-Recio, Clàudia Gil-Pitarch, María Mercado-Gómez, Laura Morán, Maider Bizkarguenaga,Fernando Lopitz-Otsoa, Petar Petrov, Miren Bravo, Sebastiaan Martijn Van Liempd, Juan Manuel Falcon-Perez, Amaia Zabala-Letona, Arkaitz Carracedo, Jos
Published in: antioxidants, 2022, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox11050897

Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling

Author(s): Ana M. Figueiredo, Pilar Villacampa, Rodrigo Diéguez-Hurtado, Juan José Lozano, Piotr Kobialka, Ana Rosa Cortazar, Anabel Martinez-Romero, Ana Angulo-Urarte, Claudio A. Franco, Marc Claret, Ana María Aransay, Ralf H. Adams, Arkaitz Carracedo, Mariona Graupera
Published in: Circulation, Issue 142/7, 2020, Page(s) 688-704, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042354

SERS analysis of cancer cell-secreted purines reveals a unique paracrine crosstalk in MTAP-deficient tumors

Author(s): Pablo S. Valera, Javier Plou, Isabel García, Ianire Astobiza, Cristina Viera, Ana M. Aransay, José E. Martin, Ivan R. Sasselli,Arkaitz Carracedo and Luis M. Liz- Marzán
Published in: PNAS, 2023, Page(s) 120/52, ISSN 1091-6490
Publisher: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2311674120

CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo.

Author(s): Abdullah Alajati; D'ambrosio Mariantonietta; Martina Troiani; Simone Mosole; Laura Pellegrini; Jingjing Chen; Ajinkya Revandkar; Marco Bolis; Jean-Philippe Theurillat; Ilaria Guccini; Marco Losa; Arianna Calcinotto; Gaston De Bernardis; Emiliano Pasquini; Rocco D'Antuono; Adam Sharp; Ines Figueiredo; Daniel Nava Rodrigues; Jonathan C. Welti; Veronica Gil; Wei Yuan; Tatjana Vlajnic; Lukas Bubendorf
Published in: Journal of Clinical Investigation 130(5) 2435-2450, Issue 1, 2020, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.3929/ethz-b-000409240

Non-peer reviewed articles (1)

Metabolism in the tumor cell and beyond

Author(s): Arkaitz Carracedo
Published in: Molecular Oncology, Vol 17, Iss 6, Pp 921-924 (2023), Issue 2, 2023, Page(s) 921-924, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.13467