Project description
Engineered bacteria in drug discovery efforts
Protein function relies on the proteins’ three-dimensional conformation and requires correct folding of the polypeptide chain. Protein misfolding leads to the accumulation of protein aggregates, which cause cellular toxicity and are a hallmark of diseases such as Alzheimer’s and Huntington’s. The EU-funded ProMiDis project is working on an innovative approach for the discovery of drugs that prevent protein misfolding. Researchers have engineered bacteria to produce drug-like molecules and identify those with an ability to inhibit protein misfolding and aggregation in mammalian cells. The proposed biotechnology platform is expected to pave the way towards the development of novel therapies against incurable diseases.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesclinical medicineendocrinologydiabetes
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein folding
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
16672 Vari-athens
Greece
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Beneficiaries (2)
16672 Vari-athens
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Participation ended
11635 Athina