Molecular control of actin network architecture and mechanics during cell shape changes

Project Information

NanoMechShape

Grant agreement ID: 820188

DOI

10.3030/820188

Project closed

EC signature date 29 March 2019

Start date 1 May 2019

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 943 071,00

EU contribution

€ 1 943 071,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (3)

Cryo-electron tomography reveals the nanoscale architecture of the actin cortex in cellular blebs

Author(s): Davide A.D. Cassani, Bruno Martins, Matthew B. Smith, Ohad Medalia, Ewa K. Paluch
Published in: BioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.03.30.587413

Synergistic action of actin binding proteins regulate actin network organization and cell shape

Author(s): Murielle P. Serres, Matthew B. Smith, Geneviève Lavoie, Philippe P. Roux, Ewa K. Paluch
Published in: BioRxiv, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.15.553706

Cell shape noise strength regulates the rate of shape change during EMT-associated cell spreading

Author(s): Wolfram Pönisch, Iskra Yanakieva, Guillaume Salbreux, Ewa K. Paluch
Published in: BioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.14.618199

Peer reviewed articles (10)

Three-dimensional geometry controls division symmetry in stem cell colonies.

Author(s): Agathe Chaigne, Matthew B. Smith, Rocio Lopez Cavestany, Edouard Hannezo, Kevin J. Chalut, Ewa K. Paluch
Published in: Journal of Cell Science, Issue 134/14, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.255018

Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate

Author(s): Henry De Belly, Aki Stubb, Ayaka Yanagida, Céline Labouesse, Philip H. Jones, Ewa K. Paluch, Kevin J. Chalut
Published in: Cell Stem Cell, Issue 28/2, 2021, Page(s) 273-284.e6, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.10.018

Proteomic analysis of the actin cortex in interphase and mitosis

Author(s): Vadnjal, Neza; Nourreddine, Sami; Lavoie, Geneviève; Serres, Murielle; Roux, Philippe P; Paluch, Ewa K
Published in: Journal of Cell Science, Issue 135/16, 2022, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1101/2022.02.16.480677

Interplay between mechanics and signalling in regulating cell fate.

Author(s): Henry De Belly, Ewa K. Paluch & Kevin J. Chalut
Published in: Nature Reviews Molecular Cell Biology, 2022, Page(s) 1-16, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-022-00472-z

Cell surface fluctuations regulate early embryonic lineage sorting.

Author(s): Ayaka Yanagida, Elena Corujo-Simon, Christopher K. Revell, Preeti Sahu, Giuliano G. Stirparo, Irene M. Aspalter, Alex K. Winkel, Ruby Peters, Henry de Belly, Davide A. D. Cassani, Sarra Achouri, Raphael Blumenfeld, Kristian Franze, Edouard Hannezo, Ewa K. Paluch, Jennifer Nichols, Kevin J. Chalut
Published in: Cell, Issue 185/5, 2022, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.01.022

Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration

Author(s): Dani L. Bodor, Wolfram Pönisch, Robert G. Endres, Ewa K. Paluch
Published in: Developmental Cell, Issue 52/5, 2020, Page(s) 550-562, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.02.013

POLCAM: Instant molecular orientation microscopy for the life sciences

Author(s): Ezra Bruggeman, Oumeng Zhang, Lisa-Maria Needham, Markus Körbel, Sam Daly, Matthew Cheetham, Ruby Peters, Tingting Wu, Andrey S. Klymchenko, Simon J. Davis, Ewa K. Paluch, David Klenerman, Matthew D. Lew, Kevin O’Holleran, Steven F. Lee
Published in: Nature Methods, 2025, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1101/2023.02.07.527479

Extent of myosin penetration within the actin cortex regulates cell surface mechanics.

Author(s): Binh An Truong Quang, Ruby Peters, Davide A. D. Cassani, Priyamvada Chugh, Andrew G. Clark, Meghan Agnew, Guillaume Charras, Ewa K. Paluch
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26611-2

Abscission Couples Cell Division to Embryonic Stem Cell Fate

Author(s): Agathe Chaigne, Céline Labouesse, Ian J. White, Meghan Agnew, Edouard Hannezo, Kevin J. Chalut, Ewa K. Paluch
Published in: Developmental Cell, Issue 55/2, 2020, Page(s) 195-208.e5, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.09.001

Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development

Author(s): Natalie J. Kirkland, Alice C. Yuen, Melda Tozluoglu, Nancy Hui, Ewa K. Paluch, Yanlan Mao
Published in: Current Biology, Issue 30/13, 2020, Page(s) 2419-2432.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.04.041

Thesis and dissertations (1)

Molecular Control of Actin Cortex Architecture During Cell Division

Author(s): Vadnjal, Neža
Published in: 2023
Publisher: UCL