Reducing the cost, time, and ethical burden of preclinical research in the pharmaceutical industry

Project Information

GENBIO

Grant agreement ID: 822455

DOI

10.3030/822455

Project closed

EC signature date 4 July 2018

Start date 1 September 2018

End date 31 August 2021

Funded under

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Total cost

€ 3 464 750,00

EU contribution

€ 2 425 325,00

Coordinated by

GENOME BIOLOGICS UG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Final (Public) Report
Large Animal … Publications + IP

Other (1)

Joint Development Publications and IP

Websites, patent fillings, videos etc. (1)

External project website

Publications

Peer reviewed articles (4)

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

Author(s): Denisa Bojkova, Julian U G Wagner, Mariana Shumliakivska, Galip S Aslan, Umber Saleem, Arne Hansen, Guillermo Luxán, Stefan Günther, Minh Duc Pham, Jaya Krishnan, Patrick N Harter, Utz H Ermel, Achilleas S Frangakis, Hendrik Milting, Andreas M Zeiher, Karin Klingel, Jindrich Cinatl, Andreas Dendorfer, Thomas Eschenhagen, Carsten Tschöpe, Sandra Ciesek, Stefanie Dimmeler
Published in: Cardiovascular Research, Issue 116/14, 2020, Page(s) 2207-2215, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaa267

Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs

Author(s): Joachim Maxeiner, Rahul Sharma, Carolin Amrhein, Frederic Gervais, Maria Duda, Jonathan Ward, Lars Friis Mikkelsen, Roy Forster, Michal Malewicz, Jaya Krishnan
Published in: Journal of Pharmacological and Toxicological Methods, Issue 108, 2021, Page(s) 106956, ISSN 1056-8719
Publisher: Elsevier BV
DOI: 10.1016/j.vascn.2021.106956

Inhibition of the Hypoxia-Inducible Factor 1α–Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease

Author(s): Peter Mirtschink, Corinne Bischof, Minh-Duc Pham, Rahul Sharma, Sanjay Khadayate, Geetha Rossi, Niklaus Fankhauser, Shuyang Traub, Samuel Sossalla, Eman Hagag, Corinne Berthonneche, Alexandre Sarre, Sebastian. N. Stehr, Phillip Grote, Thierry Pedrazzini, Stefanie Dimmeler, Wilhelm Krek, Jaya Krishnan
Published in: Circulation, Issue 139/24, 2019, Page(s) 2778-2792, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.118.036769

Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics

Author(s): Julian Uwe Gabriel Wagner, Minh Duc Pham, Luka Nicin, Marie Hammer, Katharina Bottermann, Ting Yuan, Rahul Sharma, David John, Marion Muhly-Reinholz, Lukas Tombor, Martin Hardt, Josef Madl, Stefanie Dimmeler, Jaya Krishnan
Published in: Journal of Molecular and Cellular Cardiology, Issue 138, 2020, Page(s) 269-282, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2019.12.005

Intellectual Property Rights

Patent (2)

TISSUE SELECTIVE TRANSGENE EXPRESSION

Application/Publication number: EP 16797497
Date: 2016-11-10
Applicant(s): GENOME BIOLOGICS UG

TISSUE SELECTIVE TRANSGENE EXPRESSION

Application/Publication number: EP 16797497
Date: 2016-11-10
Applicant(s): GENOME BIOLOGICS UG