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CORDIS - EU research results
CORDIS

Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Recommendations for data reproducibility training (opens in new window)

D64 Recommendations for data reproducibility training M36 EUOS

Improved protocols for compound sourcing and acquisition based on EU-OS Ambassador feedback, including a directory of cooperating chemists from each country (opens in new window)

D2.1 Improved protocols for compound sourcing and acquisition based on EU-OS Ambassador feedback, including a directory of cooperating chemists from each country (M12) (UH, USC)

Report on implementation of enhanced transfer procedures for data from EU-OS partner sites (opens in new window)

D62 Report on implementation of enhanced transfer procedures for data from EUOS partner sites M55 EUOS

Publication describing the performance of the fragment library in screening campaigns (opens in new window)

D42 Publication describing the performance of the fragment library in screening campaigns M40 OSI EMBL

Report on scientific publications and dissemination / outreach activities to new communities (opens in new window)

D93 Report on scientific publications and dissemination outreach activities to new communities M56 EUOS

Gender action plan (opens in new window)

D9.2 Gender action plan (M12) (EU-OS)

Report on outcomes of the chemical optimisation projects (opens in new window)

D32 Report on outcomes of the chemical optimisation projects including of gaps in medicinal chemistry services and recommendation for process improvements for EUOS operation M55 EUOS

Mode of action or compound distribution report for compounds from selected projects from phase 1 (responsibility of sites providing access) (opens in new window)

D51 Mode of action or compound distribution report for compounds from selected projects from phase 1 responsibility of sites providing access M33 IME

Mode of action or compound distribution report for compounds from selected projects from phase 2 (responsibility of sites providing access) (opens in new window)

D52 Mode of action or compound distribution report for compounds from selected projects from phase 2 responsibility of sites providing access M48 IME

Report on the status of co-developed screening technologies (opens in new window)

D72 Report on the status of codeveloped screening technologies M56 USC UiO

Report on available courses relevant for users and staff of EU-OS (opens in new window)

D8.1 Report on available courses relevant for users and staff of EU-OS (M12) (IMG)

Report on outcomes of the screening projects (opens in new window)

D31 Report on outcomes of the screening projects including identification of gaps in screening services and recommendation for process improvements for EUOS operation M35 EUOS

Report on improvements to the access and workflows. (opens in new window)

D1.1 Report on improvements to the access and workflows (M12) (EU-OS)

Innovation management plan (opens in new window)

D73 Innovation management plan M56 USC UiO

Report on the translation module for EU-OS screening centres (opens in new window)

D63 Report on the translation module for EUOS screening centres M55 EUOS

FBDD chemical evolution consultation service guidelines (opens in new window)

D4.1 FBDD chemical evolution consultation service guidelines (M12) (OSI, HZI)

Management guidelines (opens in new window)

D9.1 Management guidelines (M2) (EU-OS)

Report on engagement measures and successes for extension of EU-OS membership (opens in new window)

D13 Report on engagement measures and successes for extension of EUOS membership M55 EUOS

Enhanced Business Plan and financial sustainability model based on EU-OS-DRIVE outcomes (opens in new window)

D15 Enhanced Business Plan and financial sustainability model based on EUOSDRIVE outcomes M56 EUOS

Data Management Plan (opens in new window)

D6.5 Data Management Plan (M6) (EU-OS)

Final report on the EU-OS academic compound library (opens in new window)

D23 Final report on the EUOS academic compound library to include metrics on compound acquisition quality diversity uniqueness etc summaries of training events organized and recommendations for future acquisition campaigns M56 UH USC

Report on report on sustainability aspects and future perspectives for forming major strategic cooperations in the fields of chemical biology and academic drug discovery. Audiences are policy makers and funding bodies (opens in new window)

D94 Report on report on sustainability aspects and future perspectives for forming major strategic cooperations in the fields of chemical biology and academic drug discovery Audiences are policy makers and funding bodies M57 EUOS

Report on co-ordination of joined training with other BMS ESFRI projects and establishing new collaborative links (opens in new window)

D8.3 Report on co-ordination of joined training with other BMS ESFRI projects and establishing new collaborative links (M18) (IMG)

Report on existing data transfer procedures and gap analysis (opens in new window)

D6.1 Report on existing data transfer procedures and gap analysis (M6) (EU-OS)

Report on the evaluation of tools to improve compound registration (opens in new window)

D2.2 Report on the evaluation of tools to improve compound registration (M18) (UH, USC)

Roadmap for industry interactions and establishment of industry involvement in EU-OS’s activities (opens in new window)

D7.1 Roadmap for industry interactions and establishment of industry involvement in EU-OS’s activities (M8) (USC, UiO)

Report on newly developed courses organized by EU-OS-DRIVE (opens in new window)

D8.2 Report on newly developed courses organized by EU-OS-DRIVE (M18) (IMG)

Handbook and defined user workflows for two new categories of partner sites (opens in new window)

D12 Handbook and defined user workflows for two new categories of partner sites M46 EUOS

Delivery of periodic, mid-term and final reports (opens in new window)

D9.5 Delivery of periodic, mid-term and final reports (M12, 24, 36, 48) (EU-OS) due M12, M24, M36, M48

Socio-economic impact study and documented refined KPIs (opens in new window)

D1.4 Socio-economic impact study and documented refined KPIs (M56) (EU-OS)

Open Research Data Pilot (opens in new window)

Note The Assay Providing User may request an optional grace period which allows for an indepth characterisation of the identified compounds and facilitates the publication of research findings in highlevel peerreviewed journals or the application for a patent If an IP position is being sought then a grace period of up to 24 month with the possibility to extend to 36 months in exceptional circumstances may be granted These grace periods align with current practice of other initiatives eg the IMI European Lead Factory which plans to release the Qualifiedhitlists of their projects after a defined grace period

Publications

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking (opens in new window)

Author(s): Schuller, Marion Correy, Galen J. Gahbauer, Stefan Fearon, Daren Wu, Taiasean Díaz, Roberto Efraín Young, Iris D. Martins, Luan Carvalho Smith, Dominique H. Schulze-Gahmen, Ursula Owens, Tristan W. Deshpande, Ishan Merz, Gregory E. Thwin, Aye C. Biel, Justin T. Peters, Jessica K. Moritz, Michelle Herrera, Nadia Kratochvil, Huong T. Aimon, Anthony Bennett, James M. Neto, Jose Brandao Cohen, Aina
Published in: Science Advances, Issue Vol 7, Issue 16, 2021, Page(s) eabf8711, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abf8711

HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings (opens in new window)

Author(s): Pau Martin-Malpartida, Emil Hausvik, Jarl Underhaug, CarlesTorner, AuroraMartinez, Maria J.Macias
Published in: JMB Journal of Molecular Biology, Issue Volume 434, Issue 11, 15 June 2022, 167372, 2022, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.167372

Modulation of Mitochondria–Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model (opens in new window)

Author(s): Mikel Etxebeste-Mitxeltorena, Hector Flores-Romero, Sandra Ramos-Inza, Esther Masiá, Maria Nenchova, Jorge Montesinos, Loreto Martinez-Gonzalez, Gracia Porras, Mar Orzáez, María J. Vicent, Carmen Gil, Estela Area-Gomez, Ana J. Garcia-Saez, Ana Martinez
Published in: Journal of Medicinal Chemistry, 2025, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c01368

Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery (opens in new window)

Author(s): Alessandra Silvestri, Francisca Vicente, María J.Vicent, Bahne Stechmann, Wolfgang Fecke
Published in: Drug Discovery Today, Issue Volume 26, Issue 6, June 2021, 2021, Page(s) Pages 1369-1381, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2021.02.024

MBC and ECBL libraries: outstanding tools for drug discovery (opens in new window)

Author(s): Tiziana Ginex; Enrique Madruga; Ana Martinez; Carmen Gil
Published in: Frontiers in Pharmacology, Issue Volume 14 - 2023, 2023, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1244317

A Rapid, Convergent Approach to the Identification of Exosome Inhibitors in Breast Cancer Models (opens in new window)

Author(s): Zoraida Andreu; Esther Masiá; David Charbonnier; María J. Vicent
Published in: Nanotheranostics, Issue 2023 Jan 1;7(1):1-21., 2023, ISSN 2206-7418
Publisher: Ivyspring International Publisher
DOI: 10.7150/ntno.73606

Development and Characterization of a FKBP51FK1 Affinity Matrix for Protein-Protein Interaction Studies

Author(s): Stephanie Merz
Published in: 2022
Publisher: TU Darmstadt, Germany

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