Project description
Novel in vitro biomimetic organs will speed nanoparticle testing
The 'eureka' moment is rarely a moment but rather the result of years of strategic experimentation. ActiTOX is developing in vitro biomimetic systems to speed up nanoparticle-based product testing for safety and toxicity while reducing the use of animal experimentation. The team is exploiting human-induced pluripotent stem cells (iPSCs), former adult somatic cells reprogrammed to their embryonic state. Scientists will reprogramme them to differentiate into cells in tissues of interest. The iPSCs will allow ActiTOX to bypass the ethical issues associated with embryonic stem cells while retaining the ability to create biomimetic organs of choice in culture.
Objective
Nanoparticles and new drugs are undergoing complex toxicity evaluation prior to their use in products for customers.
However, the traditional pre-clinical testing protocols are delivering significant disadvantages both from ethical (animal
testing) and functional (high attrition rate in clinical testing) point of view. ActiTOX reacts to this problem by the development
of a novel, pre-clinical, high content, in vitro testing platform focused on the evaluation of nanoparticles/drugs via ADME
(absorption, distribution, metabolism, excretion) toxicity studies. In order to advance the current state of art the project will
employ biomimetic scaffolds, drug delivery systems, human induced pluripotent stem cells (iPSCs), 3D-microfluidics and
modular bioreactor technology. ActiTOX aims to increase the relevance of in vitro studies and provide a scalable approach
for their use in drug development and toxicological screening.
In order to achieve the project goals, a training network enabling efficient short-term secondments of ER and ESR between
academia and industry will be established. The cooperation between stakeholders helps closing the gap between them and oint innovation to foster the current state of the art. ActiTOX will mediate it via networking, research, training, workshop,
innovation and dissemination actions in form of short-term secondments. The project fulfils the aim of a RISE project and
delivers significant social impact, increases knowledge based economy and creates long lasting cooperation strengthening
the European research area.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology environmental biotechnology bioremediation bioreactors
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-RISE-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80686 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.