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Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

Deliverables

Public Website online

FREIA public WEB portal with description of the project, challenges and goals, project members and updates on current activities (including news/conferences/workshops).

Collaborative website (intranet) ready to use

Platform for secured internal information exchange and project documents archive.

FREIA stakeholder database (updated continuously)

Database of relevant actors and stakeholder groups for dissemination, communication and exploitation purposes.

Publications

The mammalian ovary: Concerns about the evaluation of prenatal environmental exposures

Author(s): Laetitia L. Lecante; Pauline Lelandais; Séverine Mazaud-Guittot; Paul A. Fowler
Published in: Current Opinion in Endocrine and Metabolic Research, 18, 2021, Page(s) 171–177, ISSN 2451-9650
Publisher: Elsevier Ltd.
DOI: 10.1016/j.coemr.2021.03.012

Six Decades of Research on Human Fetal Gonadal Steroids

Author(s): Stéphane Connan-Perrot, Thibaut Léger, Pauline Lelandais, Christèle Desdoits-Lethimonier, Arthur David, Paul A. Fowler, Séverine Mazaud-Guittot
Published in: International Journal of Molecular Sciences, 22/13, 2021, Page(s) 6681, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22136681

Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Author(s): Richelle D. Björvang; Ida Hallberg; Anne Pikki; Lars Berglund; Matteo Pedrelli; Hannu Kiviranta; Panu Rantakokko; Päivi Ruokojärvi; Christian H. Lindh; Matts Olovsson; Sara Persson; Jan Holte; Ylva Sjunnesson; Pauliina Damdimopoulou
Published in: Environmental Research, 208, 2021, Page(s) 112626, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.112626

The insulin-like growth factor system: A target for endocrine disruptors?

Author(s): Chiara Talia, Lisa Connolly, Paul A. Fowler
Published in: Environment International, Volume 147, February 2021, 106311, 2021, Page(s) 106311, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106311

A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals

Author(s): Delphine Franssen, Terje Svingen, David Lopez Rodriguez, Majorie Van Duursen, Julie Boberg, Anne-Simone Parent
Published in: Neuroendocrinology, 2021, ISSN 0028-3835
Publisher: S. Karger AG
DOI: 10.1159/000515478

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Author(s): Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14936-3

Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women

Author(s): Richelle D. Björvang, Pauliina Damdimopoulou
Published in: Upsala Journal of Medical Sciences, 125/2, 2020, Page(s) 85-94, ISSN 0300-9734
Publisher: Taylor & Francis
DOI: 10.1080/03009734.2020.1727073

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Author(s): Majorie B. M. van Duursen, Julie Boberg, Sofie Christiansen, Lisa Connolly, Pauliina Damdimopoulou, Panagiotis Filis, Paul A. Fowler, Bart M. Gadella, Jan Holte, Kersti Jääger, Hanna K. L. Johansson, Tianyi Li, Séverine Mazaud-Guittot, Anne-Simone Parent, Andres Salumets, Ana M. Soto, Terje Svingen, Agne Velthut-Meikas, Eva Bay Wedebye, Yuling Xie, Martin van den Berg
Published in: International Journal of Molecular Sciences, 21/9, 2020, Page(s) 3215, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093215

Dynamics of the transcriptional landscape during human fetal testis and ovary development

Author(s): Estelle Lecluze, Antoine D Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, Vincent Lavoué, Paul A Fowler, Séverine Mazaud-Guittot, Bernard Jégou, Frédéric Chalmel
Published in: Human Reproduction, 35/5, 2020, Page(s) 1099-1119, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/deaa041

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

Author(s): Chiara Talia, Edwin-Amalraj Raja, Sohinee Bhattacharya, Paul A Fowler
Published in: Human Reproduction, 2020, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/deaa091

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Author(s): Hanna Katarina Lilith Johansson, Terje Svingen, Julie Boberg, Paul A. Fowler, David Stead, Anne Marie Vinggaard, Panagiotis Filis
Published in: Archives of Toxicology, 94/4, 2020, Page(s) 1241-1250, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-020-02697-3

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Author(s): Hanna K. L. Johansson, Pauliina Damdimopoulou, Majorie B. M. van Duursen, Julie Boberg, Delphine Franssen, Marijke de Cock, Kersti Jääger, Magdalena Wagner, Agne Velthut-Meikas, Yuling Xie, Lisa Connolly, Pauline Lelandais, Severine Mazaud-Guittot, Andres Salumets, Monica Kam Draskau, Panagiotis Filis, Paul A. Fowler, Sofie Christiansen, Anne-Simone Parent, Terje Svingen
Published in: Archives of Toxicology, 2020, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-020-02834-y

Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole

Author(s): Hanna K.L. Johansson, Sofie Christiansen, Monica Kam Draskau, Terje Svingen, Julie Boberg
Published in: Reproductive Toxicology, 101, 2021, Page(s) 9-17, ISSN 0890-6238
Publisher: Elsevier BV
DOI: 10.1016/j.reprotox.2021.01.003

A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation

Author(s): Terje Svingen, Daniel L Villeneuve, Dries Knapen, Eleftheria Maria Panagiotou, Monica Kam Draskau, Pauliina Damdimopoulou, Jason M O’Brien
Published in: Toxicological Sciences, 184, 2021, Page(s) 183-190, ISSN 1096-6080
Publisher: Oxford University Press
DOI: 10.1093/toxsci/kfab113

Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: Cohort study of 151,141 singleton pregnancies

Author(s): Aikaterini Zafeiri, Edwin A. Raja, Rod T. Mitchell, David C. Hay, Sohinee Bhattacharya, Paul A. Fowler
Published in: medRxiv, 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.09.24.20200188