Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

Deliverables

Websites, patent fillings, videos etc. (2)

Public Website online

FREIA public WEB portal with description of the project, challenges and goals, project members and updates on current activities (including news/conferences/workshops).

Collaborative website (intranet) ready to use

Platform for secured internal information exchange and project documents archive.

Documents, reports (1)

FREIA stakeholder database (updated continuously)

Database of relevant actors and stakeholder groups for dissemination, communication and exploitation purposes.

Publications

Peer reviewed articles (7)

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Author(s): Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-14936-3

Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women

Author(s): Richelle D. Björvang, Pauliina Damdimopoulou
Published in: Upsala Journal of Medical Sciences, Issue 125/2, 2020, Page(s) 85-94, ISSN 0300-9734
DOI: 10.1080/03009734.2020.1727073

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Author(s): Majorie B. M. van Duursen, Julie Boberg, Sofie Christiansen, Lisa Connolly, Pauliina Damdimopoulou, Panagiotis Filis, Paul A. Fowler, Bart M. Gadella, Jan Holte, Kersti Jääger, Hanna K. L. Johansson, Tianyi Li, Séverine Mazaud-Guittot, Anne-Simone Parent, Andres Salumets, Ana M. Soto, Terje Svingen, Agne Velthut-Meikas, Eva Bay Wedebye, Yuling Xie, Martin van den Berg
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3215, ISSN 1422-0067
DOI: 10.3390/ijms21093215

Dynamics of the transcriptional landscape during human fetal testis and ovary development

Author(s): Estelle Lecluze, Antoine D Rolland, Panagiotis Filis, Bertrand Evrard, Sabrina Leverrier-Penna, Millissia Ben Maamar, Isabelle Coiffec, Vincent Lavoué, Paul A Fowler, Séverine Mazaud-Guittot, Bernard Jégou, Frédéric Chalmel
Published in: Human Reproduction, Issue 35/5, 2020, Page(s) 1099-1119, ISSN 0268-1161
DOI: 10.1093/humrep/deaa041

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

Author(s): Chiara Talia, Edwin-Amalraj Raja, Sohinee Bhattacharya, Paul A Fowler
Published in: Human Reproduction, 2020, ISSN 0268-1161
DOI: 10.1093/humrep/deaa091

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Author(s): Hanna Katarina Lilith Johansson, Terje Svingen, Julie Boberg, Paul A. Fowler, David Stead, Anne Marie Vinggaard, Panagiotis Filis
Published in: Archives of Toxicology, Issue 94/4, 2020, Page(s) 1241-1250, ISSN 0340-5761
DOI: 10.1007/s00204-020-02697-3

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Author(s): Hanna K. L. Johansson, Pauliina Damdimopoulou, Majorie B. M. van Duursen, Julie Boberg, Delphine Franssen, Marijke de Cock, Kersti Jääger, Magdalena Wagner, Agne Velthut-Meikas, Yuling Xie, Lisa Connolly, Pauline Lelandais, Severine Mazaud-Guittot, Andres Salumets, Monica Kam Draskau, Panagiotis Filis, Paul A. Fowler, Sofie Christiansen, Anne-Simone Parent, Terje Svingen
Published in: Archives of Toxicology, 2020, ISSN 0340-5761
DOI: 10.1007/s00204-020-02834-y