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Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

Objective

The FREIA consortium aims to close gaps in scientific knowledge on the mechanisms by which EDCs can affect female reproduction during specific life stages and will provide test methods to address this. The FREIA consortium has human tissue models that span the entire life cycle from fetal ovarian and adrenal tissues to child and mature ovarian follicles, that will be used identify human relevant biomarkers of EDC exposure. We will measure chemical exposures in follicular fluids and molecular profiles in granulosa cells from two IVF cohorts, and link these to fertility outcomes and patient journal information, including life-style factors and workplace. We will perform in vivo rodent studies to capture susceptible windows of exposure and identify novel endpoints for female reproductive toxicity that may be implemented in OECD test guidelines. We will provide in vitro test methods, according to OECD guidelines, for molecular and cellular events that have been implicated in female reproductive toxicity. These include ER-beta activity, GPER activity, ovarian-specific steroidogenesis, oocyte maturation and competency and hypothalamic pulsatile GnRH secretion. We will also develop QSAR models to predict interaction with aromatase and PPAR-gamma. By integrating our data from in vitro studies with primary human tissues, human exposure data from fetal and follicular fluid samples and our in vitro and in vivo research findings, the outcomes of FREIA are directly applicable to the human situation. AOPs will be developed that will form the basis for a test strategy to assess female reproductive toxicity upon exposure to EDCs, in a regulatory context. Furthermore, by expanding our scientific knowledge, the FREIA project will provide better information on EDC-related female reproductive health effects that will be used to improve reproductive health for women around the world.

Field of science

  • /social sciences/sociology/demography/fertility
  • /medical and health sciences/health sciences/social biomedical sciences/sexual health

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 529 108,75

Participants (10)

UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 239 481,25
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 783 130
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 1 025 796,25
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 456 387,50
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 463 843,75
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 493 750
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 398 915
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
TERVISETEHNOLOOGIATE ARENDUSKESKUS AS
Estonia
EU contribution
€ 311 375
Address
Teaduspargi Tn 13
50411 Tartu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 200 948,75
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
TRUSTEES OF TUFTS COLLEGE NON PROFIT CORPORATION
United States
EU contribution
€ 201 740
Address
Professors Row 20 169
02155 Medford Ma
Activity type
Higher or Secondary Education Establishments