COMMON ACTION AGAINST HIV/TB/HCV ACROSS THE REGIONS OF EUROPE

Deliverables

Documents, reports (6)

Quality Assurance Plan

This plan will detail output and outcome indicators for timely and good quality implementation.

Project fact sheet

Description of project aims and results in English and Russian. Available for download and printed

Final plan for the dissemination and exploitation of results

The final plan will include both immediate and long-term dissemination, communication and exploitation tasks and actions with the associated timeframes and responsible parties.

Recommendations on DAA treatment prioritization strategies

Draft manuscript of White paper to guide decision makers on DAA treatment prioritization stragies across the regions of Europe

The HCV CARE Cohorts

Description of the large HCV datalake and of the novel cohort of HCV unselected patients

Strategic Plan for surveillance of PDR in eastern Europe

Report to guide surveillance of HIV molecular epidemiology in eastern Europe

Websites, patent fillings, videos etc. (1)

Project website

Website of the project with intranet (project partners) and internet (public) parts in English and Russian

Other (2)

Tool to determine DRM from HTS results in eastern Europe.

Development of HTS for resistance testing of eastern European HIV subtypes The tool identifies DRM also in minor viral populations The tool will be described in a draft manuscript to be kept confidential

Geno2Pheno[TB]

Software tool to predict TB drug resistance from WGS results The tool also composes therapy regimens on the bases of standardized algorithms It will be described in a draft manuscript

Publications

Peer reviewed articles (15)

Pre-existing singleton E138A mutations in the reverse transcriptase gene do not affect the efficacy of first-line antiretroviral therapy regimens using rilpivirine in human immunodeficiency virus-infected patients

Author(s): Kuznetsova A, Lebedev A, Gromov K, Kazennova E, Zazzi M, Incardona F, Sönnerborg A, Bobkova M
Published in: Clinical Case Reports, 10/2, 2022, ISSN 2050-0904
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/ccr3.5373

Genomic Variations in Drug Resistant Mycobacterium tuberculosis Strains Collected from Patients with Different Localization of Infection

Author(s): Ekaterina Chernyaeva, Mikhail Rotkevich, Ksenia Krasheninnikova, Alla Lapidus, Dmitrii E. Polev, Natalia Solovieva, Viacheslav Zhuravlev, Piotr Yablonsky, Stephen J. O’Brien
Published in: Antibiotics, 10/1, 2021, Page(s) 27, ISSN 2079-6382
Publisher: Antibiotics
DOI: 10.3390/antibiotics10010027

Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles

Author(s): Susana Benet, Cristina Gálvez, Francis Drobniewski, Irina Kontsevaya, Lilibeth Arias, Marta Monguió‐Tortajada, Itziar Erkizia, Victor Urrea, Ruo‐Yan Ong, Marina Luquin, Maeva Dupont, Jakub Chojnacki, Judith Dalmau, Paula Cardona, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, Esther Julián, Hansjakob Furrer, Huldrych F. Günthard, Paul R. Crocker, Gustavo Tapia, Frances
Published in: Journal of Extracellular Vesicles, 10/3, 2021, ISSN 2001-3078
Publisher: J Extracell Vesicles
DOI: 10.1002/jev2.12046

In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations

Author(s): Francesco Saladini, Federica Giammarino, Behnaz A Hosseini, Alessia Giannini, Adele Boccuto, Filippo Dragoni, Ilaria Vicenti, Robert W Shafer, Maurizio Zazzi
Published in: Journal of Antimicrobial Chemotherapy, 76/1, 2020, Page(s) 130-134, ISSN 0305-7453
Publisher: Oxford University Press
DOI: 10.1093/jac/dkaa401

HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia

Author(s): Madita Schlösser, Vladimir V. Kartashev, Visa H. Mikkola, Andrey Shemshura, Sergey Saukhat, Dmitriy Kolpakov, Alexandr Suladze, Tatiana Tverdokhlebova, Katharina Hutt, Eva Heger, Elena Knops, Michael Böhm, Veronica Di Cristanziano, Rolf Kaiser, Anders Sönnerborg, Maurizio Zazzi, Marina Bobkova, Saleta Sierra
Published in: Viruses, 12/4, 2020, Page(s) 475, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12040475

Whole-Genome Metagenomic Analysis of the Gut Microbiome in HIV-1-Infected Individuals on Antiretroviral Therapy

Author(s): Xiangning Bai, Aswathy Narayanan, Piotr Nowak, Shilpa Ray, Ujjwal Neogi, Anders Sönnerborg
Published in: Frontiers in Microbiology, 12, 2021, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.667718

Genetic Profile of HIV-1 in the Vologda Region: Domination of CRF03_AB and Rapid Distribution of URFs

Author(s): E. N. Ozhmegova, A. A. Antonova, A. V. Lebedev, T. N. Melnikova, Т. V. Krylova, A. V. Kazachek, N. A. Shiryaeva, I. L. Kirillova, E. V. Kazennova, M. R. Bobkova
Published in: HIV Infection and Immunosuppressive Disorders, 12/2, 2020, Page(s) 79-88, ISSN 2077-9828
Publisher: HIV Infection and Immunosuppressive Disorders
DOI: 10.22328/2077-9828-2020-12-2-79-88

Transmitted drug resistance to NRTIs and risk of virological failure in naïve patients treated with integrase inhibitors

Author(s): A Borghetti, A Ciccullo, F Lombardi, G Baldin, S Belmonti, M Prosperi, F Incardona, E Heger, V Borghi, A Sönnerborg, M Zazzi, A De Luca, S Di Giambenedetto
Published in: HIV Medicine, 22/1, 2021, Page(s) 22-27, ISSN 1464-2662
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/hiv.12956

Prevalence and spatiotemporal dynamics of HIV-1 Circulating Recombinant Form 03_AB (CRF03_AB) in the Former Soviet Union countries

Author(s): Aleksey Lebedev, Oksana Pasechnik, Ekaterina Ozhmegova, Anastasiia Antonova, Aleksey Blokh, Liliya Grezina, Tatiana Sandyreva, Natalia Dementeva, Elena Kazennova, Marina Bobkova
Published in: PLOS ONE, 15/10, 2020, Page(s) e0241269, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0241269

MiDRMpol: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors

Author(s): Shambhu G. Aralaguppe, Anoop T. Ambikan, Manickam Ashokkumar, Milner M. Kumar, Luke Elizabeth Hanna, Wondwossen Amogne, Anders Sönnerborg, Ujjwal Neogi
Published in: Viruses, 11/9, 2019, Page(s) 806, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11090806

Molecular Surveillance of HIV-1 Infection in Krasnoyarsk Region, Russia: Epidemiology, Phylodynamics and Phylogeography

Author(s): Dmitry Neshumaev, Aleksey Lebedev, Marina Malysheva, Anatoly Boyko, Sergey Skudarnov, Ekaterina Ozhmegova, Anastasia Antonova, Elena Kazennova, Marina Bobkova
Published in: Current HIV Research, 17/2, 2019, Page(s) 114-125, ISSN 1570-162X
Publisher: Bentham Science Publishers
DOI: 10.2174/1570162x17666190618155816

Comparable in vitro activity of second-generation HIV-1 integrase strand transfer inhibitors (INSTIs) on HIV-1 clinical isolates with INSTI resistance mutations

Author(s): Francesco Saladini, Alessia Giannini, Adele Boccuto, Filippo Dragoni, Alice Appendino, Edoardo Albanesi, Ilaria Vicenti, Maurizio Zazzi
Published in: Antimicrobial Agents and Chemotherapy, 2019, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/aac.01717-19

Analysis of HIV-1 (Human immunodeficiency virus-1, Lentivirus, Orthoretrovirinae, Retroviridae) Nef protein polymorphism of variants circulating in the former USSR countries

Author(s): K. B. Gromov, E. V. Kazennova, D. E. Kireev, A. V. Murzakova, A. E. Lopatukhin, M. R. Bobkova
Published in: Problems of Virology, Russian journal, 64/6, 2020, Page(s) 281-290, ISSN 0507-4088
Publisher: Meditsina Publishers
DOI: 10.36233/0507-4088-2019-64-6-281-290

High-throughput sequencing reveals a high prevalence of pretreatment HIV-1 drug resistance in Sweden

Author(s): Emmi Andersson, Anoop Ambikan, Johanna Brännström, Shambhu G. Aralaguppe, Aylin Yilmaz, Jan Albert, Ujjwal Neogi, Anders Sönnerborg
Published in: AIDS, 35/2, 2021, Page(s) 227-234, ISSN 0269-9370
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/qad.0000000000002740

Prevalence of Antiretroviral Drug Resistance Mutations Among Pretreatment and Antiretroviral Therapy-Failure HIV Patients in Uzbekistan

Author(s): Adkhamjon Mamatkulov, Evgeniya Kazakova, Nargiz Ibadullaeva, Elizaveta Joldasova, Allabergan Bayjanov, Erkin Musabaev, Nataliya Kan, Dildora Mustafaeva, Aleksey Lebedev, Marina Bobkova, Elena Kazennova, Lev Zohrabyan
Published in: AIDS Research and Human Retroviruses, 37/1, 2021, Page(s) 38-43, ISSN 0889-2229
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/aid.2020.0096