COMMON ACTION AGAINST HIV/TB/HCV ACROSS THE REGIONS OF EUROPE

Información del proyecto

CARE

Identificador del acuerdo de subvención: 825673

DOI

10.3030/825673

Proyecto cerrado

Fecha de la firma de la CE 21 Noviembre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 30 Junio 2021

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being
• Understanding health, wellbeing and disease

Coste total

€ 3 266 842,00

Aportación de la UE

€ 2 961 912,50

Coordinado por

EURESIST NETWORK GEIE
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Quality Assurance Plan

This plan will detail output and outcome indicators for timely and good quality implementation.

Project fact sheet

Description of project aims and results in English and Russian. Available for download and printed

Final plan for the dissemination and exploitation of results

The final plan will include both immediate and long-term dissemination, communication and exploitation tasks and actions with the associated timeframes and responsible parties.

Recommendations on DAA treatment prioritization strategies

Draft manuscript of White paper to guide decision makers on DAA treatment prioritization stragies across the regions of Europe

The HCV CARE Cohorts

Description of the large HCV datalake and of the novel cohort of HCV unselected patients

Strategic Plan for surveillance of PDR in eastern Europe

Report to guide surveillance of HIV molecular epidemiology in eastern Europe

Websites, patent fillings, videos etc. (1)

Project website

Website of the project with intranet (project partners) and internet (public) parts in English and Russian

Other (2)

Tool to determine DRM from HTS results in eastern Europe.

Development of HTS for resistance testing of eastern European HIV subtypes The tool identifies DRM also in minor viral populations The tool will be described in a draft manuscript to be kept confidential

Geno2Pheno[TB]

Software tool to predict TB drug resistance from WGS results The tool also composes therapy regimens on the bases of standardized algorithms It will be described in a draft manuscript

Publicaciones

Peer reviewed articles (15)

Pre-existing singleton E138A mutations in the reverse transcriptase gene do not affect the efficacy of first-line antiretroviral therapy regimens using rilpivirine in human immunodeficiency virus-infected patients

Autores: Kuznetsova A, Lebedev A, Gromov K, Kazennova E, Zazzi M, Incardona F, Sönnerborg A, Bobkova M
Publicado en: Clinical Case Reports, Edición 10/2, 2022, ISSN 2050-0904
Editor: John Wiley & Sons Ltd
DOI: 10.1002/ccr3.5373

Genomic Variations in Drug Resistant Mycobacterium tuberculosis Strains Collected from Patients with Different Localization of Infection

Autores: Ekaterina Chernyaeva, Mikhail Rotkevich, Ksenia Krasheninnikova, Alla Lapidus, Dmitrii E. Polev, Natalia Solovieva, Viacheslav Zhuravlev, Piotr Yablonsky, Stephen J. O’Brien
Publicado en: Antibiotics, Edición 10/1, 2021, Página(s) 27, ISSN 2079-6382
Editor: Antibiotics
DOI: 10.3390/antibiotics10010027

Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles

Autores: Susana Benet, Cristina Gálvez, Francis Drobniewski, Irina Kontsevaya, Lilibeth Arias, Marta Monguió‐Tortajada, Itziar Erkizia, Victor Urrea, Ruo‐Yan Ong, Marina Luquin, Maeva Dupont, Jakub Chojnacki, Judith Dalmau, Paula Cardona, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, Esther Julián, Hansjakob Furrer, Huldrych F. Günthard, Paul R. Crocker, Gustavo Tapia, Frances
Publicado en: Journal of Extracellular Vesicles, Edición 10/3, 2021, ISSN 2001-3078
Editor: J Extracell Vesicles
DOI: 10.1002/jev2.12046

In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations

Autores: Francesco Saladini, Federica Giammarino, Behnaz A Hosseini, Alessia Giannini, Adele Boccuto, Filippo Dragoni, Ilaria Vicenti, Robert W Shafer, Maurizio Zazzi
Publicado en: Journal of Antimicrobial Chemotherapy, Edición 76/1, 2020, Página(s) 130-134, ISSN 0305-7453
Editor: Oxford University Press
DOI: 10.1093/jac/dkaa401

HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia

Autores: Madita Schlösser, Vladimir V. Kartashev, Visa H. Mikkola, Andrey Shemshura, Sergey Saukhat, Dmitriy Kolpakov, Alexandr Suladze, Tatiana Tverdokhlebova, Katharina Hutt, Eva Heger, Elena Knops, Michael Böhm, Veronica Di Cristanziano, Rolf Kaiser, Anders Sönnerborg, Maurizio Zazzi, Marina Bobkova, Saleta Sierra
Publicado en: Viruses, Edición 12/4, 2020, Página(s) 475, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12040475

Whole-Genome Metagenomic Analysis of the Gut Microbiome in HIV-1-Infected Individuals on Antiretroviral Therapy

Autores: Xiangning Bai, Aswathy Narayanan, Piotr Nowak, Shilpa Ray, Ujjwal Neogi, Anders Sönnerborg
Publicado en: Frontiers in Microbiology, Edición 12, 2021, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2021.667718

Genetic Profile of HIV-1 in the Vologda Region: Domination of CRF03_AB and Rapid Distribution of URFs

Autores: E. N. Ozhmegova, A. A. Antonova, A. V. Lebedev, T. N. Melnikova, Т. V. Krylova, A. V. Kazachek, N. A. Shiryaeva, I. L. Kirillova, E. V. Kazennova, M. R. Bobkova
Publicado en: HIV Infection and Immunosuppressive Disorders, Edición 12/2, 2020, Página(s) 79-88, ISSN 2077-9828
Editor: HIV Infection and Immunosuppressive Disorders
DOI: 10.22328/2077-9828-2020-12-2-79-88

Transmitted drug resistance to NRTIs and risk of virological failure in naïve patients treated with integrase inhibitors

Autores: A Borghetti, A Ciccullo, F Lombardi, G Baldin, S Belmonti, M Prosperi, F Incardona, E Heger, V Borghi, A Sönnerborg, M Zazzi, A De Luca, S Di Giambenedetto
Publicado en: HIV Medicine, Edición 22/1, 2021, Página(s) 22-27, ISSN 1464-2662
Editor: Blackwell Publishing Inc.
DOI: 10.1111/hiv.12956

Prevalence and spatiotemporal dynamics of HIV-1 Circulating Recombinant Form 03_AB (CRF03_AB) in the Former Soviet Union countries

Autores: Aleksey Lebedev, Oksana Pasechnik, Ekaterina Ozhmegova, Anastasiia Antonova, Aleksey Blokh, Liliya Grezina, Tatiana Sandyreva, Natalia Dementeva, Elena Kazennova, Marina Bobkova
Publicado en: PLOS ONE, Edición 15/10, 2020, Página(s) e0241269, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0241269

MiDRMpol: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors

Autores: Shambhu G. Aralaguppe, Anoop T. Ambikan, Manickam Ashokkumar, Milner M. Kumar, Luke Elizabeth Hanna, Wondwossen Amogne, Anders Sönnerborg, Ujjwal Neogi
Publicado en: Viruses, Edición 11/9, 2019, Página(s) 806, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11090806

Molecular Surveillance of HIV-1 Infection in Krasnoyarsk Region, Russia: Epidemiology, Phylodynamics and Phylogeography

Autores: Dmitry Neshumaev, Aleksey Lebedev, Marina Malysheva, Anatoly Boyko, Sergey Skudarnov, Ekaterina Ozhmegova, Anastasia Antonova, Elena Kazennova, Marina Bobkova
Publicado en: Current HIV Research, Edición 17/2, 2019, Página(s) 114-125, ISSN 1570-162X
Editor: Bentham Science Publishers
DOI: 10.2174/1570162x17666190618155816

Comparable in vitro activity of second-generation HIV-1 integrase strand transfer inhibitors (INSTIs) on HIV-1 clinical isolates with INSTI resistance mutations

Autores: Francesco Saladini, Alessia Giannini, Adele Boccuto, Filippo Dragoni, Alice Appendino, Edoardo Albanesi, Ilaria Vicenti, Maurizio Zazzi
Publicado en: Antimicrobial Agents and Chemotherapy, 2019, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/aac.01717-19

Analysis of HIV-1 (Human immunodeficiency virus-1, Lentivirus, Orthoretrovirinae, Retroviridae) Nef protein polymorphism of variants circulating in the former USSR countries

Autores: K. B. Gromov, E. V. Kazennova, D. E. Kireev, A. V. Murzakova, A. E. Lopatukhin, M. R. Bobkova
Publicado en: Problems of Virology, Russian journal, Edición 64/6, 2020, Página(s) 281-290, ISSN 0507-4088
Editor: Meditsina Publishers
DOI: 10.36233/0507-4088-2019-64-6-281-290

High-throughput sequencing reveals a high prevalence of pretreatment HIV-1 drug resistance in Sweden

Autores: Emmi Andersson, Anoop Ambikan, Johanna Brännström, Shambhu G. Aralaguppe, Aylin Yilmaz, Jan Albert, Ujjwal Neogi, Anders Sönnerborg
Publicado en: AIDS, Edición 35/2, 2021, Página(s) 227-234, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/qad.0000000000002740

Prevalence of Antiretroviral Drug Resistance Mutations Among Pretreatment and Antiretroviral Therapy-Failure HIV Patients in Uzbekistan

Autores: Adkhamjon Mamatkulov, Evgeniya Kazakova, Nargiz Ibadullaeva, Elizaveta Joldasova, Allabergan Bayjanov, Erkin Musabaev, Nataliya Kan, Dildora Mustafaeva, Aleksey Lebedev, Marina Bobkova, Elena Kazennova, Lev Zohrabyan
Publicado en: AIDS Research and Human Retroviruses, Edición 37/1, 2021, Página(s) 38-43, ISSN 0889-2229
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/aid.2020.0096