Taking advantage of the expertise diversity of the 11 partners from the OBERON project, existing and newly generated data will be integrated to develop test systems to detect endocrine disruptors related to metabolism. Several existing EU-cohorts are analyzed, and cellular models, zebrafish models and computational approaches are used. During the first period, we started the establishment and harmonization of several experimental tests across the different EU laboratories. Some experimental results have been already produced, and a network science-based model was established, but the COVID-19 crisis slowed down the full project. All these results will be used for computational modeling to create the final tiered tests, and to develop new adverse outcome pathway (AOPs) for metabolism. During this first period, expected deliverables including ethics, and publications were achieved.