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An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Objective

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

Call for proposal

H2020-SC1-BHC-2018-2020

See other projects for this call

Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 1 900 553,75
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (14)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE PARIS CITE
France
Net EU contribution
€ 0,00
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 200 422,00
Region
Ile-de-France Ile-de-France Paris
 
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE DE BORDEAUX
France
Net EU contribution
€ 0,00
Address
Place Pey Berland 35
33000 Bordeaux
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 342 000,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE DE RENNES I
France
Net EU contribution
€ 0,00
Address
Rue Du Thabor 2
35065 Rennes Cedex
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 224 710,00
INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS
France
Net EU contribution
€ 558 945,00
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
Non-EU contribution
€ 0,00
BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY
Czechia
Net EU contribution
€ 215 250,00
Address
Kralovopolska 135
CZ-61265 Brno
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Net EU contribution
€ 259 706,25
Address
Avenida De La Universidad S-n
03202 Elche
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
Net EU contribution
€ 793 725,00
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Θεσσαλονίκη Κεντρική Μακεδονία Βόρεια Ελλάδα
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain
Net EU contribution
€ 550 366,25
Address
C Rossello 132 Planta 05
08036 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Net EU contribution
€ 304 000,00
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Masarykova univerzita
Czechia
Net EU contribution
€ 330 407,50
Address
Zerotinovo Namesti 9
601 77 Brno
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
METABOLON GMBH

Participation ended

Germany
Net EU contribution
€ 0,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Zeppelinstrasse 3
85399 Hallbergmoos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
Net EU contribution
€ 76 058,75
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSERM TRANSFERT SA
France
Net EU contribution
€ 379 750,00
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ENVE.X SINGLE MEMBER PC
Greece
Net EU contribution
€ 610 000,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Kosti Palama 11
551 33 Thesaloniki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Θεσσαλονίκη Κεντρική Μακεδονία Βόρεια Ελλάδα