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Integrated human data repositories for infectious disease-related international cohorts to foster personalized medicine approaches to infectious disease research

Objective

EU-CAN-SHARE builds on existing infrastructures and partnerships to develop a sustainable model for the storage, curation, and analyses of the complex data sets collected by infectious disease (ID)-related cohorts. While ID cohorts collect both clinical-epidemiological (CE) and terabytes of OMICS data, storage and analysis of CE and high dimensional laboratory (HDL) data remains separate and developing the infrastructure for housing and analysing HDL data is not feasible for individual studies. In this project, we develop innovative approaches to the synthesis and analysis of CE&HDL data, and modify governance models for cloud-based repositories elaborated by and for scientists in high-income countries to meet the specific challenges of synthesizing CE&HDL data and sharing data across international cohorts and with the Open Science community. We develop data architecture and governance that link biobanks to data repositories to facilitate equitable use, collaborative, cross-domain analyses, and replicability. The team leverages partnerships with multicentre ID cohorts in the global South, and connects EU investments in OMICS infrastructures with Canadian expertise on pipeline and workflow development, biostatistical methods, and ethical and governance issues related to the establishment of repositories for CE&HDL data in resource-limited settings. Drawing from best practice and governance elaborated for similar initiatives, the repository will employ a federated model where a tiered permission system and cohort-specific hubs facilitate cohorts’ analysis of their own data, cross-cohort analyses, and connections with the open science community within a clearly elaborated legal, ethical, and equitable framework. The cloud-based platform will provide analytic tools and computational power to facilitate cross-domain, collaborative analyses that inform personalized medicine approaches to diagnostic, treatment, and vaccine development in ID-focused international cohorts.

Field of science

  • /social sciences/sociology/governance

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITATSKLINIKUM HEIDELBERG
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 236 980

Participants (12)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 741 212,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 375 000
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 429 370
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 565 775
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Universidad Industrial de Santander
Colombia
EU contribution
€ 490 542,50
Address
Ciudad Universitaria-carrera 27 Calle 9
Bucaramanga
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF BRITISH COLUMBIA
Canada
EU contribution
€ 0
Address
Agronomy Road 102-6190
V6T1Z1 Vancouver
Activity type
Higher or Secondary Education Establishments
MCMASTER UNIVERSITY
Canada
EU contribution
€ 0
Address
1280 Main St West
L8S 4L8 Hamilton
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 683 750
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
EU contribution
€ 0
Address
845 Sherbrooke Street West
H3A0G4 Montreal
Activity type
Higher or Secondary Education Establishments
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 128 575
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
INSTITUT PASTEUR DE DAKAR
Senegal
EU contribution
€ 123 250
Address
Avenue Pasteur 36
DAKAR Dakar
Activity type
Research Organisations
SUSTAINABLE SCIENCES INSTITUTE
United States
EU contribution
€ 185 570
Address
870 Market Street Suite 764
94102 San Francisco
Activity type
Research Organisations