Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation

Deliverables

Documents, reports (1)

Report on in silico bioavailability triggers applied to TDCs

Status report on the on in silico bioavailability triggers applied to TDCs

Publications

Peer reviewed articles (20)

Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

Author(s): Barbara Kubickova, Carmel Ramwell, Klara Hilscherova, Miriam Naomi Jacobs
Published in: Environmental Sciences Europe, 33/1, 2021, Page(s) 20, ISSN 2190-4707
Publisher: Springer Verlag
DOI: 10.1186/s12302-020-00428-0

Thyroid-like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Author(s): Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G.
Published in: Integrated Environmental Assessment and Management, 2022, ISSN 1551-3793
Publisher: Society of Environmental Toxicology and Chemistry (SETAC)
DOI: 10.1002/ieam.4632

Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen.

Author(s): Flamant, F., Zekri, Y. and Guyot, R.
Published in: Endocrinology, 163 (8), 2022, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/endocr/bqac084

AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish via Altered Retinal Layer Structure

Author(s): Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D., and Vergauwen, L.
Published in: Environmental Toxicology and Chemistry, Vol 41. Issue 8, 2022, ISSN 1552-8618
Publisher: Wiley
DOI: 10.1002/etc.5452

Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain

Author(s): Quentin Hamdaoui; Yanis Zekri; Sabine Richard; Denise Aubert; Romain Guyot; Suzy Markossian; Karine Gauthier; François Gaie-Levrel; Anna Bencsik; Frédéric Flamant
Published in: Chemosphere, 287 Part 3, 2022, Page(s) 132253, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2021.132253

Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities

Author(s): Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O.
Published in: Frontiers in Toxicology, Volume 3, Article 787017, 2021, ISSN 2673-3080
Publisher: Frontiers Media
DOI: 10.3389/ftox.2021.787017

A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation.

Author(s): Svingen, T., Villeneuve, D. L., Knapen, D., Panagiotou, E. M., Draskau, M. K., Damdimopoulou, P., & O’Brien, J. M.
Published in: Toxicological Sciences, Volume 184 Issue 2, 2021, Page(s) Pages 183–190, ISSN 1096-6080
Publisher: Oxford University Press
DOI: 10.1093/toxsci/kfab113

Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study

Author(s): Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L.
Published in: Journal of Hazardous Materials, vol. 424, 2022, Page(s) 127705, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.127705

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice.

Author(s): Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J.
Published in: Science signaling, 15 (738), eabj4583, 2022, ISSN 1945-0877
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abj4583

Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic

Author(s): Zekri, Y., Flamant, F., & Gauthier, K.
Published in: Cells, 10(6):1, 2021, Page(s) 1327-1330, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10061327

Sex chromosomes in meiotic, hemiclonal, clonal and polyploid hybrid vertebrates: along the ‘extended speciation continuum'

Author(s): Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K.
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, 2021, Page(s) p. 20200103, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2020.0103

PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes

Author(s): Nichlas Davidsen; Louise Ramhøj; Claus Asger Lykkebo; Indusha Kugathas; Rikke Poulsen; Anna Kjerstine Rosenmai; Bertrand Evrard; Thomas A. Darde; Marta Axelstad; Martin Iain Bahl; Martin Hansen; Frederic Chalmel; Tine Rask Licht; Terje Svingen
Published in: Davidsen , N , Ramhøj , L , Lykkebo , C A , Kugathas , I , Poulsen , R , Rosenmai , A K , Evrard , B , Darde , T A , Axelstad , M , Bahl , M I , Hansen , M , Chalmel , F , Licht , T R & Svingen , T 2022 , ' PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes ' , Environmental Pollution , vol. 305 , 119340 . https://doi.org/10.1016/j.envpol.202, 2, 2022, Page(s) 119340, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2022.119340

Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution

Author(s): Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N.
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, 2021, Page(s) p. 20200097, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2020.0097

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Author(s): Karine Rousseau, Sylvie Dufour, Laurent M. Sachs
Published in: Frontiers in Ecology and Evolution, 9, 2021, ISSN 2296-701X
Publisher: Frontiers
DOI: 10.3389/fevo.2021.735487

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

Author(s): Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant
Published in: iScience, 23/3, 2020, Page(s) 100899, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2020.100899

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

Author(s): Henrik Holbech, Peter Matthiessen, Martin Hansen, Gerrit Schüürmann, Dries Knapen, Marieke Reuver, Frédéric Flamant, Laurent Sachs, Werner Kloas, Klara Hilscherova, Marc Leonard, Jürgen Arning, Volker Strauss, Taisen Iguchi, Lisa Baumann
Published in: International Journal of Molecular Sciences, 21/8, 2020, Page(s) 2954, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082954

Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish

Author(s): Evelyn Stinckens, Lucia Vergauwen, Brett R. Blackwell, Gerald T. Ankley, Daniel L. Villeneuve, Dries Knapen
Published in: Environmental Science & Technology, 54/10, 2020, Page(s) 6213-6223, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.9b07204

Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption

Author(s): Dries Knapen, Evelyn Stinckens, Jenna E. Cavallin, Gerald T. Ankley, Henrik Holbech, Daniel L. Villeneuve, Lucia Vergauwen
Published in: Environmental Science & Technology, 2020, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.9b07205

In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors

Author(s): Yanis Zekri, Laure Dall Agnol, Frédéric Flamant, Romain Guyot
Published in: iScience, 24/9, 2021, Page(s) 102957, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.102957

Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis

Author(s): Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M.
Published in: Cells 11, no. 10, 2022, Page(s) 1595, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11101595

Thesis dissertations (1)

Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway.

Author(s): Anna Melina Steinbach
Published in: 2021
Publisher: University of Milan and BASF SE

Conference proceedings (1)

"Sex chromosomes in so-called ""asexual"" hybrid vertebrates: along the ‘extended speciation continuum’"

Author(s): Matthias Stöck , Dmitrij Dedukh , Radka Reifová , Dunja K. Lamatsch , Zuzana Starostová, Karel Janko
Published in: """ESEB Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne """, 2021
Publisher: European Society of Evolutionary Biology