Deliverables Documents, reports (1) Report on in silico bioavailability triggers applied to TDCs Status report on the on in silico bioavailability triggers applied to TDCs Publications Peer reviewed articles (20) Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study Author(s): Barbara Kubickova, Carmel Ramwell, Klara Hilscherova, Miriam Naomi Jacobs Published in: Environmental Sciences Europe, 33/1, 2021, Page(s) 20, ISSN 2190-4707 Publisher: Springer Verlag DOI: 10.1186/s12302-020-00428-0 Thyroid-like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals Author(s): Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G. Published in: Integrated Environmental Assessment and Management, 2022, ISSN 1551-3793 Publisher: Society of Environmental Toxicology and Chemistry (SETAC) DOI: 10.1002/ieam.4632 Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen. Author(s): Flamant, F., Zekri, Y. and Guyot, R. Published in: Endocrinology, 163 (8), 2022, ISSN 0013-7227 Publisher: The Endocrine Society DOI: 10.1210/endocr/bqac084 AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish via Altered Retinal Layer Structure Author(s): Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D., and Vergauwen, L. Published in: Environmental Toxicology and Chemistry, Vol 41. Issue 8, 2022, ISSN 1552-8618 Publisher: Wiley DOI: 10.1002/etc.5452 Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain Author(s): Quentin Hamdaoui; Yanis Zekri; Sabine Richard; Denise Aubert; Romain Guyot; Suzy Markossian; Karine Gauthier; François Gaie-Levrel; Anna Bencsik; Frédéric Flamant Published in: Chemosphere, 287 Part 3, 2022, Page(s) 132253, ISSN 0045-6535 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.chemosphere.2021.132253 Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities Author(s): Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O. Published in: Frontiers in Toxicology, Volume 3, Article 787017, 2021, ISSN 2673-3080 Publisher: Frontiers Media DOI: 10.3389/ftox.2021.787017 A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation. Author(s): Svingen, T., Villeneuve, D. L., Knapen, D., Panagiotou, E. M., Draskau, M. K., Damdimopoulou, P., & O’Brien, J. M. Published in: Toxicological Sciences, Volume 184 Issue 2, 2021, Page(s) Pages 183–190, ISSN 1096-6080 Publisher: Oxford University Press DOI: 10.1093/toxsci/kfab113 Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study Author(s): Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L. Published in: Journal of Hazardous Materials, vol. 424, 2022, Page(s) 127705, ISSN 0304-3894 Publisher: Elsevier BV DOI: 10.1016/j.jhazmat.2021.127705 A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice. Author(s): Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J. Published in: Science signaling, 15 (738), eabj4583, 2022, ISSN 1945-0877 Publisher: American Association for the Advancement of Science DOI: 10.1126/scisignal.abj4583 Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic Author(s): Zekri, Y., Flamant, F., & Gauthier, K. Published in: Cells, 10(6):1, 2021, Page(s) 1327-1330, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells10061327 Sex chromosomes in meiotic, hemiclonal, clonal and polyploid hybrid vertebrates: along the ‘extended speciation continuum' Author(s): Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K. Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, 2021, Page(s) p. 20200103, ISSN 0962-8436 Publisher: Royal Society of London DOI: 10.1098/rstb.2020.0103 PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes Author(s): Nichlas Davidsen; Louise Ramhøj; Claus Asger Lykkebo; Indusha Kugathas; Rikke Poulsen; Anna Kjerstine Rosenmai; Bertrand Evrard; Thomas A. Darde; Marta Axelstad; Martin Iain Bahl; Martin Hansen; Frederic Chalmel; Tine Rask Licht; Terje Svingen Published in: Davidsen , N , Ramhøj , L , Lykkebo , C A , Kugathas , I , Poulsen , R , Rosenmai , A K , Evrard , B , Darde , T A , Axelstad , M , Bahl , M I , Hansen , M , Chalmel , F , Licht , T R & Svingen , T 2022 , ' PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes ' , Environmental Pollution , vol. 305 , 119340 . https://doi.org/10.1016/j.envpol.202, 2, 2022, Page(s) 119340, ISSN 0269-7491 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.envpol.2022.119340 Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution Author(s): Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N. Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, 2021, Page(s) p. 20200097, ISSN 0962-8436 Publisher: Royal Society of London DOI: 10.1098/rstb.2020.0097 Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions Author(s): Karine Rousseau, Sylvie Dufour, Laurent M. Sachs Published in: Frontiers in Ecology and Evolution, 9, 2021, ISSN 2296-701X Publisher: Frontiers DOI: 10.3389/fevo.2021.735487 A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons Author(s): Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant Published in: iScience, 23/3, 2020, Page(s) 100899, ISSN 2589-0042 Publisher: Cell Press DOI: 10.1016/j.isci.2020.100899 ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters Author(s): Henrik Holbech, Peter Matthiessen, Martin Hansen, Gerrit Schüürmann, Dries Knapen, Marieke Reuver, Frédéric Flamant, Laurent Sachs, Werner Kloas, Klara Hilscherova, Marc Leonard, Jürgen Arning, Volker Strauss, Taisen Iguchi, Lisa Baumann Published in: International Journal of Molecular Sciences, 21/8, 2020, Page(s) 2954, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21082954 Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish Author(s): Evelyn Stinckens, Lucia Vergauwen, Brett R. Blackwell, Gerald T. Ankley, Daniel L. Villeneuve, Dries Knapen Published in: Environmental Science & Technology, 54/10, 2020, Page(s) 6213-6223, ISSN 0013-936X Publisher: American Chemical Society DOI: 10.1021/acs.est.9b07204 Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption Author(s): Dries Knapen, Evelyn Stinckens, Jenna E. Cavallin, Gerald T. Ankley, Henrik Holbech, Daniel L. Villeneuve, Lucia Vergauwen Published in: Environmental Science & Technology, 2020, ISSN 0013-936X Publisher: American Chemical Society DOI: 10.1021/acs.est.9b07205 In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors Author(s): Yanis Zekri, Laure Dall Agnol, Frédéric Flamant, Romain Guyot Published in: iScience, 24/9, 2021, Page(s) 102957, ISSN 2589-0042 Publisher: Elsevier DOI: 10.1016/j.isci.2021.102957 Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis Author(s): Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M. Published in: Cells 11, no. 10, 2022, Page(s) 1595, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells11101595 Thesis dissertations (1) Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway. Author(s): Anna Melina Steinbach Published in: 2021 Publisher: University of Milan and BASF SE Conference proceedings (1) "Sex chromosomes in so-called ""asexual"" hybrid vertebrates: along the ‘extended speciation continuum’" Author(s): Matthias Stöck , Dmitrij Dedukh , Radka Reifová , Dunja K. Lamatsch , Zuzana Starostová, Karel Janko Published in: """ESEB Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne """, 2021 Publisher: European Society of Evolutionary Biology Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
