Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation

The metabolome of pink-footed goose: Heavy metals and lipid metabolism

Autori: Mette Jensen; Rikke Poulsen; Rikke Langebæk; Bjørn Munro Jenssen; Johanna Moe; Tomasz M. Ciesielski; Rune Dietz; Christian Sonne; Jesper Madsen; Martin Hansen
Pubblicato in: Environmental Research, Numero 231, 116043, 2023, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2023.116043

Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

Autori: Barbara Kubickova, Carmel Ramwell, Klara Hilscherova, Miriam Naomi Jacobs
Pubblicato in: Environmental Sciences Europe, Numero 33/1, 2021, Pagina/e 20, ISSN 2190-4707
Editore: Springer Verlag
DOI: 10.1186/s12302-020-00428-0

Thyroid-like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Autori: Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G.
Pubblicato in: Integrated Environmental Assessment and Management, 2022, ISSN 1551-3793
Editore: Society of Environmental Toxicology and Chemistry (SETAC)
DOI: 10.1002/ieam.4632

Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen.

Autori: Flamant, F., Zekri, Y. and Guyot, R.
Pubblicato in: Endocrinology, Numero 163 (8), 2022, ISSN 0013-7227
Editore: The Endocrine Society
DOI: 10.1210/endocr/bqac084

AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish via Altered Retinal Layer Structure

Autori: Gölz, L., Baumann, L., Pannetier, P., Braunbeck, T., Knapen, D., and Vergauwen, L.
Pubblicato in: Environmental Toxicology and Chemistry, Numero Vol 41. Numero 8, 2022, ISSN 1552-8618
Editore: Wiley
DOI: 10.1002/etc.5452

Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish.

Autori: Van Dingenen, I., Vergauwen, L., Haigis, A., Blackwell, B. R., Stacy, E., Villeneuve, D. L., & Knapen, D.
Pubblicato in: Aquatic Toxicology, Numero 261, 106632, 2023, ISSN 0166-445X
Editore: Elsevier BV
DOI: 10.1016/j.aquatox.2023.106632

Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain

Autori: Quentin Hamdaoui; Yanis Zekri; Sabine Richard; Denise Aubert; Romain Guyot; Suzy Markossian; Karine Gauthier; François Gaie-Levrel; Anna Bencsik; Frédéric Flamant
Pubblicato in: Chemosphere, Numero 287 Part 3, 2022, Pagina/e 132253, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2021.132253

An Atlas of Thyroid Hormone Receptors’ Target Genes in Mouse Tissues

Autori: Yanis Zekri; Romain Guyot; Frédéric Flamant
Pubblicato in: International Journal of Molecular Sciences, Numero 1, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2022.08.16.504127

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish.

Autori: Horie, Y., Nomura, M., Okamoto, K., Takahashi, C., Sato, T., Miyagawa, S., Okamura, H., & Iguchi, T.
Pubblicato in: Journal of Applied Toxicology, Numero 42(8), 2022, Pagina/e 1385–1395, ISSN 1099-1263
Editore: Wiley
DOI: 10.1002/jat.4302

Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.

Autori: Haigis, A., Vergauwen, L., LaLone, C. A., Villeneuve, D. L., O’Brien, J. M., & Knapen, D.
Pubblicato in: Toxicological Sciences, 2023, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfad063

Reversibility of thyroid hormone system‐disrupting effects on eye and thyroid follicle development in zebrafish (Danio rerio) embryos.

Autori: Pannetier, P., Poulsen, R., Gölz, L., Coordes, S., Stegeman, H., Koegst, J., Reger, L., Braunbeck, T., Hansen, M. R. H., & Baumann, L.
Pubblicato in: Environmental Toxicology and Chemistry, Numero 42(6), 1276–1292, 2023, ISSN 1552-8618
Editore: Wiley
DOI: 10.1002/etc.5608

Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities

Autori: Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O.
Pubblicato in: Frontiers in Toxicology, Numero Volume 3, Article 787017, 2021, ISSN 2673-3080
Editore: Frontiers Media
DOI: 10.3389/ftox.2021.787017

A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation.

Autori: Svingen, T., Villeneuve, D. L., Knapen, D., Panagiotou, E. M., Draskau, M. K., Damdimopoulou, P., & O’Brien, J. M.
Pubblicato in: Toxicological Sciences, Numero Volume 184 Numero 2, 2021, Pagina/e Pages 183–190, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfab113

Relationship between serum thyroid hormones and their associated metabolites, and gene expression bioindicators in the back skin of Rana [Lithobates] catesbeiana tadpoles and frogs during metamorphosis

Autori: Poulsen, Rikke; Jackman, Shireen H.; Hansen, Martin; Helbing, Caren C.
Pubblicato in: Frontiers in Endocrinology, Numero 13: 1103051, 2023, ISSN 1664-2392
Editore: Frontiers Media
DOI: 10.3389/fendo.2022.1103051

Thyroid hormone as a temporal switch in mouse development

Autori: Flamant, F. and Ren, J.
Pubblicato in: European Thyroid Journal, Numero 12(2), 2023, ISSN 2235-0802
Editore: Bioscientifica
DOI: 10.1530/etj-22-0225

Developmental exposure to triclosan and benzophenone-2 causes morphological alterations in zebrafish (Danio rerio) thyroid follicles and eyes.

Autori: Maximilian Kraft; Lisa Gölz; Maximilian Rinderknecht; Johannes Koegst; Thomas Braunbeck; Lisa Baumann
Pubblicato in: Environmental Science and Pollution Research, Numero 30, 2023, Pagina/e 33711–33724, ISSN 1614-7499
Editore: Springer Science + Business Media
DOI: 10.1007/s11356-022-24531-2

Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study

Autori: Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L.
Pubblicato in: Journal of Hazardous Materials, Numero vol. 424, 2022, Pagina/e 127705, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.127705

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice.

Autori: Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J.
Pubblicato in: Science signaling, Numero 15 (738), eabj4583, 2022, ISSN 1945-0877
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.abj4583

Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic

Autori: Zekri, Y., Flamant, F., & Gauthier, K.
Pubblicato in: Cells, Numero 10(6):1, 2021, Pagina/e 1327-1330, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10061327

Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges.

Autori: Katyeny Manuela Da Silva; Elias Iturrospe; Chloé Bars; Dries Knapen; Steven Van Cruchten; Adrian Covaci; Alexander L.N. van Nuijs
Pubblicato in: Metabolites, Numero 2, 2021, ISSN 2218-1989
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/metabo11090635

Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

Autori: Yanis Zekri; Romain Guyot; Inés Garteizgogeascoa Suñer; Laurence Canaple; Amandine Gautier-Stein; Justine Vily-Petit; Denise Aubert; Sabine Richard; Frédéric Flamant; Karine Gauthier
Pubblicato in: Elife 11: e81996, Numero 4, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.81996

Sex chromosomes in meiotic, hemiclonal, clonal and polyploid hybrid vertebrates: along the ‘extended speciation continuum'

Autori: Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K.
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero vol. 376, no. 1833, 2021, Pagina/e p. 20200103, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2020.0103

PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes

Autori: Nichlas Davidsen; Louise Ramhøj; Claus Asger Lykkebo; Indusha Kugathas; Rikke Poulsen; Anna Kjerstine Rosenmai; Bertrand Evrard; Thomas A. Darde; Marta Axelstad; Martin Iain Bahl; Martin Hansen; Frederic Chalmel; Tine Rask Licht; Terje Svingen
Pubblicato in: Davidsen , N , Ramhøj , L , Lykkebo , C A , Kugathas , I , Poulsen , R , Rosenmai , A K , Evrard , B , Darde , T A , Axelstad , M , Bahl , M I , Hansen , M , Chalmel , F , Licht , T R & Svingen , T 2022 , ' PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes ' , Environmental Pollution , vol. 305 , 119340 . https://doi.org/10.1016/j.envpol.202, Numero 2, 2022, Pagina/e 119340, ISSN 0269-7491
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2022.119340

Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima)

Autori: Even Fjære; Rikke Poulsen; Arne Duinker; Bjørn Liaset; Martin Hansen; Lise Madsen; Lene Secher Myrmel
Pubblicato in: Foods, Numero 11: 24, 2022, ISSN 2304-8158
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/foods11243943

Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution

Autori: Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N.
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero vol. 376, no. 1833, 2021, Pagina/e p. 20200097, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2020.0097

Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system.

Autori: Tribondeau, A., Sachs, L.M. and Buisine, N.
Pubblicato in: Frontiers in Genetics 13:996826, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.996826

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Autori: Karine Rousseau, Sylvie Dufour, Laurent M. Sachs
Pubblicato in: Frontiers in Ecology and Evolution, Numero 9, 2021, ISSN 2296-701X
Editore: Frontiers
DOI: 10.3389/fevo.2021.735487

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

Autori: Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant
Pubblicato in: iScience, Numero 23/3, 2020, Pagina/e 100899, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2020.100899

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

Autori: Henrik Holbech, Peter Matthiessen, Martin Hansen, Gerrit Schüürmann, Dries Knapen, Marieke Reuver, Frédéric Flamant, Laurent Sachs, Werner Kloas, Klara Hilscherova, Marc Leonard, Jürgen Arning, Volker Strauss, Taisen Iguchi, Lisa Baumann
Pubblicato in: International Journal of Molecular Sciences, Numero 21/8, 2020, Pagina/e 2954, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082954

Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish

Autori: Evelyn Stinckens, Lucia Vergauwen, Brett R. Blackwell, Gerald T. Ankley, Daniel L. Villeneuve, Dries Knapen
Pubblicato in: Environmental Science & Technology, Numero 54/10, 2020, Pagina/e 6213-6223, ISSN 0013-936X
Editore: American Chemical Society
DOI: 10.1021/acs.est.9b07204

Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption

Autori: Dries Knapen, Evelyn Stinckens, Jenna E. Cavallin, Gerald T. Ankley, Henrik Holbech, Daniel L. Villeneuve, Lucia Vergauwen
Pubblicato in: Environmental Science & Technology, 2020, ISSN 0013-936X
Editore: American Chemical Society
DOI: 10.1021/acs.est.9b07205

In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors

Autori: Yanis Zekri, Laure Dall Agnol, Frédéric Flamant, Romain Guyot
Pubblicato in: iScience, Numero 24/9, 2021, Pagina/e 102957, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2021.102957

Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?

Autori: Ramhøj, L., Guyot, R., Svingen, T., Kortenkamp, A., Flamant, F. and Axelstad, M.
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 142, 105445, 2023, ISSN 0273-2300
Editore: Academic Press
DOI: 10.1016/j.yrtph.2023.105445

(2023). Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes).

Autori: Horie, Y., Yamagishi, T., Yamamoto, J., Suzuki, M., Onishi, Y., Chiba, T., Miyagawa, S., Lange, A., Tyler, C. R., Okamura, H., & Iguchi, T.
Pubblicato in: Comparative Biochemistry and Physiology C-toxicology & Pharmacology, Numero 263, 109502, 2023, ISSN 1532-0456
Editore: Elsevier BV
DOI: 10.1016/j.cbpc.2022.109502

Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis

Autori: Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M.
Pubblicato in: Cells 11, no. 10, 2022, Pagina/e 1595, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11101595

Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation

Autori: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Pubblicato in: OECD Series on Adverse Outcome Pathways, Numero No. 24, 2022
Editore: OECD Publishing
DOI: 10.1787/9cb525e9-en.

Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation”,

Autori: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Pubblicato in: OECD Series on Adverse Outcome Pathways, Numero No. 25, 2022
Editore: OECD Publishing
DOI: 10.1787/9f651c16-en

Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation

Autori: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Pubblicato in: OECD Series on Adverse Outcome Pathways, Numero No. 22, 2022
Editore: OECD Publishing
DOI: 10.1787/dc406014-en.

Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation

Autori: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Pubblicato in: OECD Series on Adverse Outcome Pathways, Numero No. 23, 2022
Editore: OECD Publishing
DOI: 10.1787/b1bf0bea-en.

Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation

Autori: Vergauwen, L., Stinckens, E., Villeneuve, D.L., Knapen, D.
Pubblicato in: OECD Series on Adverse Outcome Pathways, Numero No.26, 2022
Editore: OECD Publishing
DOI: 10.1787/447c5cba-en

Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway.

Autori: Anna Melina Steinbach
Pubblicato in: 2021
Editore: University of Milan and BASF SE

"Sex chromosomes in so-called ""asexual"" hybrid vertebrates: along the ‘extended speciation continuum’"

Autori: Matthias Stöck , Dmitrij Dedukh , Radka Reifová , Dunja K. Lamatsch , Zuzana Starostová, Karel Janko
Pubblicato in: """ESEB Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne """, 2021
Editore: European Society of Evolutionary Biology

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