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Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Objective

Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for implementation of these tools and endpoints into regulatory frameworks. In this way, ENDpoiNTs will meet the scientific, regulatory, and societal needs for improved hazard and risk assessment of EDCs

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

UPPSALA UNIVERSITET
Net EU contribution
€ 945 322,50
Address
Von Kraemers Alle 4
751 05 Uppsala
Sweden

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (18)

STICHTING VU
Netherlands
Net EU contribution
€ 926 776,25
Address
De Boelelaan 1105
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BRUNEL UNIVERSITY LONDON
United Kingdom
Net EU contribution
€ 112 500,00
Address
Kingston Lane
UB8 3PH Uxbridge

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Region
London Outer London — West and North West Harrow and Hillingdon
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 220 755,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

MUSEUM NATIONAL D'HISTOIRE NATURELLE
France
Net EU contribution
€ 94 682,50
Address
Rue Cuvier 57
75005 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
GREEN TOX GMBH
Switzerland
Net EU contribution
€ 411 890,00
Address
Langackerstrasse 49
8057 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 141 716,25
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
Net EU contribution
€ 315 525,00
Address
Boulevard De L'hopital 47
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IUF - LEIBNIZ-INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG GMBH
Germany
Net EU contribution
€ 1 071 300,00
Address
Auf M Hennekamp 50
40225 Dusseldorf

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Region
Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt
Activity type
Other
Non-EU contribution
€ 0,00
KARLSTADS UNIVERSITET
Sweden
Net EU contribution
€ 101 677,00
Address
Universitetsgatan 2
651 88 Karlstad

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Region
Norra Sverige Norra Mellansverige Värmlands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
UNIVERSITAT KONSTANZ
Germany
Net EU contribution
€ 300 000,00
Address
Universitatsstrasse 10
78464 Konstanz

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 632 133,75
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 898 517,50
Address
Via Festa Del Perdono 7
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
Net EU contribution
€ 124 972,50
Address
One Gustave L Levy Place Box 1075
10029 6574 New York

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF QUEENSLAND
Australia
Net EU contribution
€ 0,00
Non-EU contribution
€ 156 250,00
MURDOCH CHILDRENS RESEARCH INSTITUTE

Participation ended

Australia
Net EU contribution
€ 0,00
Non-EU contribution
€ 195 995,00
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Net EU contribution
€ 199 375,00
Address
Avenida De Seneca 2
28040 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UMEA UNIVERSITET
Sweden
Net EU contribution
€ 198 750,00
Address
Universitetomradet
901 87 Umea

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Region
Norra Sverige Övre Norrland Västerbottens län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 334 856,25
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF MELBOURNE
Australia
Net EU contribution
€ 0,00
Address
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 195 995,00