Project description DEENESFRITPL The role of endocrine disruptors on the developing brain Endocrine-disrupting chemicals (EDCs) are substances encountered in the environment that mimic or interfere with the function of hormones, causing a variety of health issues. Examples include dioxins, phthalates and lead. The EU-funded ENDpoiNTs project is interested to understand how EDCs may cause developmental neurotoxicity and increase the risk for disease in adult life or cause cognitive, learning and behavioural issues. Researchers will advance scientific knowledge on the association between EDCs and developmental neurotoxicity and develop an EDC-screening framework with cellular and computational tools. Project results will improve current policies on EDCs to protect vulnerable populations. Show the project objective Hide the project objective Objective Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for implementation of these tools and endpoints into regulatory frameworks. In this way, ENDpoiNTs will meet the scientific, regulatory, and societal needs for improved hazard and risk assessment of EDCs Fields of science natural sciencesbiological sciencesdevelopmental biologysocial sciencessociologygovernancecrisis managementnatural sciencescomputer and information sciencesartificial intelligencemachine learningmedical and health sciencesbasic medicinetoxicology Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) SC1-BHC-27-2018 - New testing and screening methods to identify endocrine disrupting chemicals Call for proposal H2020-SC1-BHC-2018-2020 See other projects for this call Sub call H2020-SC1-2018-Single-Stage-RTD Funding Scheme RIA - Research and Innovation action Coordinator UPPSALA UNIVERSITET Net EU contribution € 1 048 433,94 Address Von kraemers alle 4 751 05 Uppsala Sweden See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (18) Sort alphabetically Sort by Net EU contribution Expand all Collapse all STICHTING VU Netherlands Net EU contribution € 926 776,25 Address De boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BRUNEL UNIVERSITY LONDON United Kingdom Net EU contribution € 112 500,00 Address Kingston lane UB8 3PH Uxbridge See on map Region London Outer London — West and North West Harrow and Hillingdon Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 220 755,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. MUSEUM NATIONAL D'HISTOIRE NATURELLE France Net EU contribution € 94 682,50 Address Rue cuvier 57 75005 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GREEN TOX GMBH Switzerland Net EU contribution € 411 890,00 Address Langackerstrasse 49 8057 Zurich See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 141 716,25 INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE France Net EU contribution € 315 525,00 Address Boulevard de l'hopital 47 75013 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IUF - LEIBNIZ-INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG GMBH Germany Net EU contribution € 1 071 300,00 Address Auf m hennekamp 50 40225 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KARLSTADS UNIVERSITET Sweden Net EU contribution € 101 677,00 Address Universitetsgatan 2 651 88 Karlstad See on map Region Norra Sverige Norra Mellansverige Värmlands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 UNIVERSITAT KONSTANZ Germany Net EU contribution € 300 000,00 Address Universitatsstrasse 10 78464 Konstanz See on map Region Baden-Württemberg Freiburg Konstanz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT UTRECHT Netherlands Net EU contribution € 632 133,75 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI MILANO Italy Net EU contribution € 898 517,50 Address Via festa del perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI United States Net EU contribution € 124 972,50 Address One gustave l levy place box 1075 10029 6574 New york See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE UNIVERSITY OF QUEENSLAND Australia Net EU contribution € 0,00 Address St lucia 4072 Brisbane See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 156 250,00 MURDOCH CHILDRENS RESEARCH INSTITUTE Participation ended Australia Net EU contribution € 0,00 Address Flemington road rch 3052 Parkville See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 195 995,00 UNIVERSIDAD COMPLUTENSE DE MADRID Spain Net EU contribution € 199 375,00 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UMEA UNIVERSITET Sweden Net EU contribution € 198 750,00 Address Universitetomradet 901 87 Umea See on map Region Norra Sverige Övre Norrland Västerbottens län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KAROLINSKA INSTITUTET Participation ended Sweden Net EU contribution € 231 744,81 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY OF MELBOURNE Australia Net EU contribution € 0,00 Address Parkvilleoffice of the vice chancellor 3010 Melbourne See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 195 995,00