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Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity


1st animation

First animation video showing highlights of the project results

Launch of Website, logo and flyer

Launch of Website, logo and flyer

Set of test compounds

Final list of the set of chemicals tested in WP2 and WP3.


Author(s): Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen
Published in: ALTEX, Issue 36(4), 2019, Page(s) 682-699, ISSN 1868-596X
DOI: 10.14573/altex.1909271

CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

Author(s): Christiaan Karreman
Published in: ALTEX, Issue 37(2), 2020, Page(s) 332-336, ISSN 1868-596X
DOI: 10.14573/altex.2003191

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

Author(s): Alice Krebs
Published in: ALTEX, Issue 37(1), 2019, Page(s) 155-163, ISSN 1868-596X
DOI: 10.14573/altex.1912021

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

Author(s): Nadine Dreser, Katrin Madjar, Anna-Katharina Holzer, Marion Kapitza, Christopher Scholz, Petra Kranaster, Simon Gutbier, Stefanie Klima, David Kolb, Christian Dietz, Timo Trefzer, Johannes Meisig, Christoph van Thriel, Margit Henry, Michael R. Berthold, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Tanja Waldmann, Marcel Leist
Published in: Archives of Toxicology, Issue 94/1, 2020, Page(s) 151-171, ISSN 0340-5761
DOI: 10.1007/s00204-019-02612-5

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Author(s): Michelle Leemans, Stephan Couderq, Barbara Demeneix, Jean-Baptiste Fini
Published in: Frontiers in Endocrinology, Issue 10, 2019, ISSN 1664-2392
DOI: 10.3389/fendo.2019.00743

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Author(s): Diana Lupu, Patrik Andersson, Carl-Gustaf Bornehag, Barbara Demeneix, Ellen Fritsche, Chris Gennings, Walter Lichtensteiger, Marcel Leist, Pim E. G. Leonards, Anne-Louise Ponsonby, Martin Scholze, Giuseppe Testa, Jesus A. F. Tresguerres, Remco H. S. Westerink, Bernard Zalc, Joëlle Rüegg
Published in: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 3978, ISSN 1422-0067
DOI: 10.3390/ijms21113978

Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development

Author(s): Barbara A. Demeneix
Published in: European Thyroid Journal, Issue 8/6, 2019, Page(s) 283-292, ISSN 2235-0640
DOI: 10.1159/000504668

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

Author(s): Alejandro López-Tobón, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco De Simone, Isabel Liste-Noya, Giuseppe Macino, Massimiliano Pagani, Elena Cattaneo, Giuseppe Testa
Published in: Stem Cell Reports, Issue 13/5, 2019, Page(s) 847-861, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2019.09.005

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

Author(s): Markus Brüll
Published in: ALTEX, Issue 37(3), 2020, Page(s) 409-428, ISSN 1868-596X
DOI: 10.14573/altex.1911111

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

Author(s): Christiaan Karreman
Published in: ALTEX, Issue 36(3), 2019, Page(s) 518-520, ISSN 1868-596X
DOI: 10.14573/altex.1906251