Deliverables Websites, patent fillings, videos etc. (3) 1st animation First animation video showing highlights of the project results 2nd animation Second animation video showing highlights of the project results Launch of Website, logo and flyer Launch of Website, logo and flyer Documents, reports (1) Set of test compounds Final list of the set of chemicals tested in WP2 and WP3. Publications Peer reviewed articles (28) A human stem cell-derived test system for agents modifying neuronal N -methyl- d -aspartate-type glutamate receptor Ca 2+ -signalling Author(s): Stefanie Klima; Markus Brüll; Anna-Sophie Spreng; Ilinca Suciu; Tjalda Falt; Jens Christian Schwamborn; Tanja Waldmann; Christiaan Karreman; Marcel Leist Published in: Archives of Toxicology, Issue 6, 2021, ISSN 1432-0738 Publisher: Springer Verlag DOI: 10.1007/s00204-021-03024-0 Human neuronal signaling and communication assays to assess functional neurotoxicity. Author(s): Dominik Loser; Jasmin Schaefer; Timm Danker; Clemens Möller; Markus Brüll; Ilinca Suciu; Anna-Katharina Ückert; Stefanie Klima; Marcel Leist; Udo Kraushaar Published in: Archives of Toxicology, Issue 5, 2021, ISSN 1432-0738 Publisher: Springer Verlag DOI: 10.1007/s00204-020-02956-3 https://www.altex.org/index.php/altex/article/view/1339 Author(s): Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen Published in: ALTEX, Issue 36(4), 2019, Page(s) 682-699, ISSN 1868-596X Publisher: Springer-Verlag Gmb DOI: 10.14573/altex.1909271 CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes Author(s): Christiaan Karreman Published in: ALTEX, Issue 37(2), 2020, Page(s) 332-336, ISSN 1868-596X Publisher: Springer-Verlag GmbH DOI: 10.14573/altex.2003191 Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling. Author(s): Dominik Loser; Dominik Loser; Karin Grillberger; Maria G. Hinojosa; Jonathan Blum; Yves Haufe; Timm Danker; Ylva Johansson; Clemens Möller; Annette Nicke; Susanne Hougaard Bennekou; Iain Gardner; Caroline Bauch; Paul Walker; Anna Forsby; Gerhard F. Ecker; Udo Kraushaar; Marcel Leist Published in: Archives of Toxicology, Issue 7, 2021, ISSN 1432-0738 Publisher: Springer Verlag DOI: 10.1007/s00204-021-03168-z Environmental influences on brain aging Author(s): Barbara A. Demeneix Published in: Aging Brain,Volume 1, 2021, 100003, Issue 7, 2021, ISSN 2589-9589 Publisher: Elsevier DOI: 10.1016/j.nbas.2020.100003 Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays Author(s): Alice Krebs Published in: ALTEX, Issue 37(1), 2019, Page(s) 155-163, ISSN 1868-596X Publisher: Springer -Verlag GmbH DOI: 10.14573/altex.1912021 Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology Author(s): Cristina Cheroni; Cristina Cheroni; Nicolò Caporale; Nicolò Caporale; Giuseppe Testa; Giuseppe Testa Published in: Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020), Issue 2, 2020, ISSN 2040-2392 Publisher: BioMed Central DOI: 10.1186/s13229-020-00370-1 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors Author(s): Johannes Delp; Andrea Cediel-Ulloa; Andrea Cediel-Ulloa; Ilinca Suciu; Petra Kranaster; Barbara M.A. van Vugt-Lussenburg; Vesna Munic Kos; Wanda van der Stel; Giada Carta; Susanne Hougaard Bennekou; Paul Jennings; Bob van de Water; Anna Forsby; Anna Forsby; Marcel Leist Published in: Delp , J , Cediel-Ulloa , A , Suciu , I , Kranaster , P , van Vugt-Lussenburg , B M , Munic Kos , V , van der Stel , W , Carta , G , Bennekou , S H , Jennings , P , van de Water , B , Forsby , A & Leist , M 2021 , ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ' , Archives of Toxicology , vol. 95 , pp. 591–615 . https://doi.org/10.1007/s00204-020, Issue 5, 2021, ISSN 1432-0738 Publisher: Springer DOI: 10.1007/s00204-020-02970-5 DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study Author(s): Elin Engdahl, Katherine Svensson, Ping-I Daniel Lin, Ali Alavian-Ghavaninic, Christian Lindh, Joëlle Rüegg, Carl-Gustaf Bornehag Published in: Environment International, Volume 156, November 2021, 106617, 2021, ISSN 0160-4120 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.envint.2021.106617 Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons. Author(s): Dominik Loser; Maria G. Hinojosa; Jonathan Blum; Jasmin Schaefer; Markus Brüll; Ylva Johansson; Ilinca Suciu; Karin Grillberger; Timm Danker; Clemens Möller; Iain Gardner; Gerhard F. Ecker; Susanne Hougaard Bennekou; Anna Forsby; Udo Kraushaar; Marcel Leist Published in: Archives of Toxicology, Issue 1, 2021, ISSN 1432-0738 Publisher: Springer Verlag DOI: 10.1007/s00204-021-03031-1 Identification of mitochondrial toxicants by combined in silico and in vitro studies : a structure-based view on the Adverse Outcome Pathway Author(s): Florentina Troger; Johannes Delp; Melina Funke; Wanda van der Stel; Claire Colas; Marcel Leist; Bob van de Water; Gerhard F. Ecker Published in: Computational Toxicology, 14, Issue 8, 2020, ISSN 2468-1113 Publisher: Elsevier DOI: 10.1016/j.comtox.2020.100123 Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances Author(s): Nadine Dreser, Katrin Madjar, Anna-Katharina Holzer, Marion Kapitza, Christopher Scholz, Petra Kranaster, Simon Gutbier, Stefanie Klima, David Kolb, Christian Dietz, Timo Trefzer, Johannes Meisig, Christoph van Thriel, Margit Henry, Michael R. Berthold, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Tanja Waldmann, Marcel Leist Published in: Archives of Toxicology, Issue 94/1, 2020, Page(s) 151-171, ISSN 0340-5761 Publisher: Springer Verlag DOI: 10.1007/s00204-019-02612-5 Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities Author(s): Karine Audouze, Elias Zgheib, Khaled Abass, Asma H. Baig, Isabel Forner-Piquer, Henrik Holbech, Dries Knapen, Pim E. G. Leonards, Diana I. Lupu, Saranya Palaniswamy, Arja Rautio, Maria Sapounidou, Olwenn V. Martin Published in: Front. Toxicol, 2021, ISSN 2673-3080 Publisher: Frontiers DOI: 10.3389/ftox.2021.787017 Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays Author(s): Xenia Dolde; Christiaan Karreman; Marianne Wiechers; Stefan Schildknecht; Marcel Leist Published in: International Journal of Molecular Sciences, Vol 22, Iss 10079, p 10079 (2021), Issue 9, 2021, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms221810079 Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System Author(s): Davide Marangon, Nicolò Caporale, Marta Boccazzi, Maria P. Abbracchio, Giuseppe Testa, Davide Lecca Published in: Frontiers in cellular neuroscience, 2021, ISSN 1662-5102 Publisher: Frontiers Research Foundation DOI: 10.3389/fncel.2021.748849 Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data Author(s): Michelle Leemans, Stephan Couderq, Barbara Demeneix, Jean-Baptiste Fini Published in: Frontiers in Endocrinology, Issue 10, 2019, ISSN 1664-2392 Publisher: Frontiers DOI: 10.3389/fendo.2019.00743 The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity Author(s): Diana Lupu, Patrik Andersson, Carl-Gustaf Bornehag, Barbara Demeneix, Ellen Fritsche, Chris Gennings, Walter Lichtensteiger, Marcel Leist, Pim E. G. Leonards, Anne-Louise Ponsonby, Martin Scholze, Giuseppe Testa, Jesus A. F. Tresguerres, Remco H. S. Westerink, Bernard Zalc, Joëlle Rüegg Published in: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 3978, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21113978 Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development Author(s): Barbara A. Demeneix Published in: European Thyroid Journal, Issue 8/6, 2019, Page(s) 283-292, ISSN 2235-0640 Publisher: S. Karger AG DOI: 10.1159/000504668 TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs Author(s): Jördis Klose, Julia Tigges, Stefan Masjosthusmann, Katharina Schmuck, Farina Bendt, Ulrike Hübenthal, Patrick Petzsch, Karl Köhrer, Katharina Koch, Ellen Fritsche Published in: ALTEX, 2021, ISSN 1868-8551 Publisher: Springer spectrum DOI: 10.14573/altex.2007201 Handling deviating control values in concentration-response curves. Author(s): Franziska Kappenberg; Tim Brecklinghaus; Wiebke Albrecht; Jonathan Blum; Carola van der Wurp; Marcel Leist; Jan G. Hengstler; Jörg Rahnenführer Published in: Archives of Toxicology, Issue 2, 2020, ISSN 1432-0738 Publisher: Springer Verlag DOI: 10.1007/s00204-020-02913-0 Culture of Rat Primary Cortical Cells for Microelectrode Array (MEA) Recordings to Screen for Acute and Developmental Neurotoxicity Author(s): Lora-Sophie Gerber, Lennart V J van Melis, Regina G D M van Kleef, Aart de Groot, Remco H S Westerink Published in: Curr Protoc . 2021 Jun;1(6):e158, 2021, ISSN 2691-1299 Publisher: Wiley DOI: 10.1002/cpz1.158 The sociability spectrum: evidence from reciprocal genetic copy number variations. Author(s): Alejandro López-Tobón; Alejandro López-Tobón; Sebastiano Trattaro; Sebastiano Trattaro; Giuseppe Testa; Giuseppe Testa Published in: Molecular Autism, Vol 11, Iss 1, Pp 1-13 (2020), Issue 2, 2020, ISSN 2040-2392 Publisher: BioMed Central DOI: 10.1186/s13229-020-00347-0 Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation. Author(s): Johannes Meisig; Johannes Meisig; Nadine Dreser; Marion Kapitza; Margit Henry; Tamara Rotshteyn; Jörg Rahnenführer; Jan G. Hengstler; Agapios Sachinidis; Tanja Waldmann; Marcel Leist; Nils Blüthgen; Nils Blüthgen Published in: Nucleic Acids Research, Issue 1, 2020, ISSN 1362-4962 Publisher: Oxford University Press DOI: 10.1093/nar/gkaa1089 Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis Author(s): Alejandro López-Tobón, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco De Simone, Isabel Liste-Noya, Giuseppe Macino, Massimiliano Pagani, Elena Cattaneo, Giuseppe Testa Published in: Stem Cell Reports, Issue 13/5, 2019, Page(s) 847-861, ISSN 2213-6711 Publisher: Cell Press DOI: 10.1016/j.stemcr.2019.09.005 Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies Author(s): Markus Brüll Published in: ALTEX, Issue 37(3), 2020, Page(s) 409-428, ISSN 1868-596X Publisher: Springer-Verlag GmbH DOI: 10.14573/altex.1911111 Myelin replacement triggered by single-cell demyelination in mouse cortex. Author(s): Nicolas Snaidero; Martina Schifferer; Aleksandra Mezydlo; Bernard Zalc; Martin Kerschensteiner; Thomas Misgeld; Thomas Misgeld Published in: Nature Communications, Issue 8, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-18632-0 SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging Author(s): Christiaan Karreman Published in: ALTEX, Issue 36(3), 2019, Page(s) 518-520, ISSN 1868-596X Publisher: Springer - Verlag GMB DOI: 10.14573/altex.1906251 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
