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EUCANCan: a federated network of aligned and interoperable infrastructures for the homogeneous analysis, management and sharing of genomic oncology data for Personalized Medicine.

Deliverables

Ethico-legal issues for EU partners in EUCANCan

Report on ethicolegal issues relevant to the participation of EUCANCan member projects in Spain Germany and other relevant Member States including a description of requirements in German Spanish and EU legislation to share health data for EUCANCans purposes of the project

Definition of global and local needs regarding storing solutions for raw data from oncological patients, and the different levels of security required for personalised medicine environments

Reporting of the specific needs of each data producing site/partner, the different profiles of user communities and their level of data access. Integrate ethical and legal solutions described in WP6 for the different levels of protection

Policy working group briefings, summary reports_1

Briefing documents that were prepared for the health policy group, and documentation of regular meetings and progress

File-level federated query system back end

Design and implement a pilot version of data query and retrieval systems within EUCanCan federated network. Adaptation to data types and formats defined in WP5.

Tools report

Best practices including tools, parameters and workflows to analyse the different types of data (just a report, no code at this stage) along with validated and annotated datasets for different use cases (variant calling, RNA-seq analysis, etc.).

Policy working group briefings, summary reports_2

Briefing documents that were prepared for the health policy group and documentation of regular meetings and progress

Communication plan

Guidelines for communication, including key messages, main target audiences, most suitable communication channels, rules to be followed, and a social media strategy

EUCANCan Exploitation Plan

Overview document listing the Key Exploitable results of the project and responsible partners, including planned exploitation timelines and pathways (to be updated with each periodic report)

Description and implementation of exchange of genomics data

The investigated and defined exchange formats for genomics data within EUCANCan will be formulary described Based on the chosen standard the API for the exchange will be defined implemented and reported

Canadian ethico-legal constraints and considerations report

Report on ethico-legal constraints and considerations for Canadian projects in receiving data transfers according to the EU General Data Protection Regulation, and sharing and processing data according to Canadian personal information protection law

Protocols for deploying tools and pipelines locally

Identify points of integration of eventual storage solutions locally Adaptation of one end to each site according to their needs

Guidance to enable the sharing of clinical data within the EUCANCan project

This will include a description of the safeguards implemented by EUCANCan to ensure that technical and organisational measures are in place for the processing of data as well as the obligations of parties involved in the data processing

Description and implementation of clinical data types and formats for the sharing of datasets within EUCANCan

Description of the data attributes in the two tier system of clinical annotation (first mandatory baseline clinicopathological data, second minimal follow-up and outcome information) and their implementation as a consensus across sites for the sharing of datasets within EUCANCan

Project Management and Quality Guidelines

This deliverable will describe the project’s internal management procedures, detailing the project’s Quality assurance process as well as a detailed Risk evaluation and internal communication tools and mechanisms.

Updated versions of EGA software and ELIXIR Data Transfer technologies

Implement functional versions of software for data transfer in and out of storing systems

Software packages with the pipelines able to run within the informatics infrastructure developed in WP3

Stateoftheart pipelines provided in D21 and D22 will be implemented according to harmonised guidelines using best practises of software engineering Portable informatics scripts will be packaged allowing the installation and running of the pipelines within the EUCANCan informatics infrastructure

Automated tools to filter and prioritize both genomic and somatic alterations to support decision making during tumour boards

A list of analysis tools parameters and databases to compute scores to classify the variants to assess their potential functional impact within the tumor and their druggability will be provided Bioinformatics scripts will be implemented and integrated within the general analysis pipelines to automatically compute these scores

Final version of EUCANCan variant extraction and annotation tool

Identify the best solutions to replicate and align strategies for the calling and interpretation of somatic and germline variants (SNVs, indels, SVs and CNV) for a concordant and homogeneous sharing of genomic information across EUCANCan nodes. These strategies will be also aligned with current efforts to standardize protocols for genomic analyses in biomedicine (GA4GH and ELIXIR).

Dissemination toolkit

Corporate identity will be developed, and dissemination materials as well as templates to be used for presentations, reports, meeting- and internal documents

Public project website

To showcase the project’s activities and results both to the scientific community as well as to the public at large

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Publications

Geniac: Automatic Configuration GENerator and Installer for nextflow pipelines

Author(s): Fabrice Allain; Julien Roméjon; Philippe La Rosa; Frédéric Jarlier; Nicolas Servant; Philippe Hupé
Published in: Open Research Europe, 2021, ISSN 2732-5121
Publisher: F1000
DOI: 10.12688/openreseurope.13861.1

Mutational Landscape and Tumor Burden Assessed by Cell-free DNA in Diffuse Large B-Cell Lymphoma in a Population-Based Study

Author(s): Alfredo Rivas-Delgado, Ferran Nadeu, Anna Enjuanes; Sebastián Casanueva-Eliceiry, Pablo Mozas, Laura Magnano; Natalia Castrejón de Anta; Jordina Rovira; Ivan Dlouhy; Silvia Martín; Miguel Osuna; Sonia Rodríguez; Marc Simó; Magda Pinyol; Tycho Baumann; Silvia Beà Olga Balagué; Julio Delgado; Neus Villamor; Xavier Setoain; Elías Campo Eva Giné; Armando López-Guillermo
Published in: Clinical Cancer Research, 2021, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-2558

Women’s Views on Multifactorial Breast Cancer Risk Assessment and Risk-Stratified Screening: A Population-Based Survey from Four Provinces in Canada

Author(s): Cynthia Mbuya-Bienge , Nora Pashayan, Jennifer D. Brooks, Michel Dorval, Jocelyne Chiquette, Laurence Eloy, Annie Turgeon, Laurence Lambert-Côté , Jean-Sébastien Paquette , Emmanuelle Lévesque , Julie Hagan , Meghan J. Walker , Julie Lapointe , Gratien Dalpé, Palmira Granados Moreno , Kristina Blackmore, Michael Wolfson, Yann Joly, Mireille Broeders , Bartha M. Knoppers , Anna M. Chiarelli ,
Published in: Journal of Personalized Medicine, 2021, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm11020095

Toward better governance of human genomic data

Author(s): Kieran C. O’Doherty, Mahsa Shabani, Edward S. Dove, Heidi Beate Bentzen, Pascal Borry, Michael M. Burgess, Don Chalmers, Jantina De Vries, Lisa Eckstein, Stephanie M. Fullerton, Eric Juengst, Kazuto Kato, Jane Kaye, Bartha Maria Knoppers, Barbara A. Koenig, Spero M. Manson, Kimberlyn M. McGrail, Amy L. McGuire, Eric M. Meslin, Dianne Nicol, Barbara Prainsack, Sharon F. Terry, Adrian Thorogood an
Published in: Nat Genet, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-00742-6

La compartición internacional de datos personales relativos a la salud en tiempos de la COVID-19: aspectos éticos y legales para el impulso de la necesaria cooperación

Author(s): Mikel Recuero Linares
Published in: RBD. Revista de Bioética y Derecho, 2, 2020, ISSN 1886-5887
Publisher: Spain
DOI: 10.1344/rbd2020.50.31711

Raising standards for global data-sharing—Response

Author(s): Jasper Bovenberg David PeloquinBarbara BiererMark Barnesand Bartha Maria Knoppers
Published in: Science, 2021, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abf5425

Ethical challenges of precision cancer medicine

Author(s): Eva Caroline Winkler, Bartha Maria Knoppers
Published in: Seminars in Cancer Biology, 2020, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2020.09.009