Deliverables
Report on ethicolegal issues relevant to the participation of EUCANCan member projects in Spain Germany and other relevant Member States including a description of requirements in German Spanish and EU legislation to share health data for EUCANCans purposes of the project
Reporting of the specific needs of each data producing site/partner, the different profiles of user communities and their level of data access. Integrate ethical and legal solutions described in WP6 for the different levels of protection
Briefing documents that were prepared for the health policy group, and documentation of regular meetings and progress
Design and implement a pilot version of data query and retrieval systems within EUCanCan federated network. Adaptation to data types and formats defined in WP5.
Best practices including tools, parameters and workflows to analyse the different types of data (just a report, no code at this stage) along with validated and annotated datasets for different use cases (variant calling, RNA-seq analysis, etc.).
Briefing documents that were prepared for the health policy group and documentation of regular meetings and progress
Guidelines for communication, including key messages, main target audiences, most suitable communication channels, rules to be followed, and a social media strategy
Overview document listing the Key Exploitable results of the project and responsible partners, including planned exploitation timelines and pathways (to be updated with each periodic report)
The investigated and defined exchange formats for genomics data within EUCANCan will be formulary described Based on the chosen standard the API for the exchange will be defined implemented and reported
Report on ethico-legal constraints and considerations for Canadian projects in receiving data transfers according to the EU General Data Protection Regulation, and sharing and processing data according to Canadian personal information protection law
Identify points of integration of eventual storage solutions locally Adaptation of one end to each site according to their needs
This will include a description of the safeguards implemented by EUCANCan to ensure that technical and organisational measures are in place for the processing of data as well as the obligations of parties involved in the data processing
Description of the data attributes in the two tier system of clinical annotation (first mandatory baseline clinicopathological data, second minimal follow-up and outcome information) and their implementation as a consensus across sites for the sharing of datasets within EUCANCan
This deliverable will describe the project’s internal management procedures, detailing the project’s Quality assurance process as well as a detailed Risk evaluation and internal communication tools and mechanisms.
Implement functional versions of software for data transfer in and out of storing systems
Stateoftheart pipelines provided in D21 and D22 will be implemented according to harmonised guidelines using best practises of software engineering Portable informatics scripts will be packaged allowing the installation and running of the pipelines within the EUCANCan informatics infrastructure
A list of analysis tools parameters and databases to compute scores to classify the variants to assess their potential functional impact within the tumor and their druggability will be provided Bioinformatics scripts will be implemented and integrated within the general analysis pipelines to automatically compute these scores
Identify the best solutions to replicate and align strategies for the calling and interpretation of somatic and germline variants (SNVs, indels, SVs and CNV) for a concordant and homogeneous sharing of genomic information across EUCANCan nodes. These strategies will be also aligned with current efforts to standardize protocols for genomic analyses in biomedicine (GA4GH and ELIXIR).
Corporate identity will be developed, and dissemination materials as well as templates to be used for presentations, reports, meeting- and internal documents
To showcase the project’s activities and results both to the scientific community as well as to the public at large
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Publications
Author(s): Fabrice Allain; Julien Roméjon; Philippe La Rosa; Frédéric Jarlier; Nicolas Servant; Philippe Hupé
Published in: Open Research Europe, 2021, ISSN 2732-5121
Publisher: F1000
DOI: 10.12688/openreseurope.13861.1
Author(s): Alfredo Rivas-Delgado, Ferran Nadeu, Anna Enjuanes; Sebastián Casanueva-Eliceiry, Pablo Mozas, Laura Magnano; Natalia Castrejón de Anta; Jordina Rovira; Ivan Dlouhy; Silvia Martín; Miguel Osuna; Sonia Rodríguez; Marc Simó; Magda Pinyol; Tycho Baumann; Silvia Beà Olga Balagué; Julio Delgado; Neus Villamor; Xavier Setoain; Elías Campo Eva Giné; Armando López-Guillermo
Published in: Clinical Cancer Research, 2021, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-2558
Author(s): Cynthia Mbuya-Bienge , Nora Pashayan, Jennifer D. Brooks, Michel Dorval, Jocelyne Chiquette,
Laurence Eloy, Annie Turgeon, Laurence Lambert-Côté , Jean-Sébastien Paquette ,
Emmanuelle Lévesque , Julie Hagan , Meghan J. Walker , Julie Lapointe , Gratien Dalpé,
Palmira Granados Moreno , Kristina Blackmore, Michael Wolfson, Yann Joly, Mireille Broeders ,
Bartha M. Knoppers , Anna M. Chiarelli ,
Published in: Journal of Personalized Medicine, 2021, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm11020095
Author(s): Kieran C. O’Doherty, Mahsa Shabani, Edward S. Dove, Heidi Beate Bentzen, Pascal Borry,
Michael M. Burgess, Don Chalmers, Jantina De Vries, Lisa Eckstein, Stephanie M. Fullerton,
Eric Juengst, Kazuto Kato, Jane Kaye, Bartha Maria Knoppers, Barbara A. Koenig, Spero M. Manson,
Kimberlyn M. McGrail, Amy L. McGuire, Eric M. Meslin, Dianne Nicol, Barbara Prainsack, Sharon F. Terry,
Adrian Thorogood an
Published in: Nat Genet, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-00742-6
Author(s): Mikel Recuero Linares
Published in: RBD. Revista de Bioética y Derecho, 2, 2020, ISSN 1886-5887
Publisher: Spain
DOI: 10.1344/rbd2020.50.31711
Author(s): Jasper Bovenberg David PeloquinBarbara BiererMark Barnesand Bartha Maria Knoppers
Published in: Science, 2021, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abf5425
Author(s): Eva Caroline Winkler, Bartha Maria Knoppers
Published in: Seminars in Cancer Biology, 2020, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2020.09.009