Skip to main content

Developing an Artificial Intestine for the sustainable farming of healthy fish

Objective

A healthy, balanced diet has a fundamental role in preventing a large range of chronic diseases and contributes to prolong life quality with obvious benefits for the individual as well as for the society. Aquaculture production plays a substantial role in this perspective because fish is an important source of well-balanced proteins and important nutrients such as marine-derived omega-3 fatty acids. However, its sustainability generates concerns as farmed fish diet is largely based on fishmeal and fish oil. Consumer and environmental groups demand a continued move towards alternative feeds. Objective of this project is to develop a next generation 3D culture platform that accurately mimics the complex functions of the intestinal mucosa. Its purpose is to make available a technology for predicting the health and nutritional value of innovative components of aquafeeds. Current methods are lengthy, expensive and requires the use of large number of animals. Furthermore, they do not provide the knowledge of the cellular and molecular mechanisms determining the final effect of each meal on the fish. This lack of mechanistic knowledge severely limits our capacity to understand and predict the biological value of the single raw material and of their different combinations. We propose to develop new ad hoc biomaterials to create a 3D scaffold where to grow and differentiate a complete population of intestinal epithelial cells. Combining state of the art notions on fish nutrition will lead to a fully functional prototype of artificial intestine (Fish-AI) that will enable the feed industry to predict accurately and efficiently the health and nutritional value of alternative feed sources substantially improving European aquaculture sustainability and competitiveness. The project fosters cross-fertilisation and synergy among nutrition physiology, bioengineering, cell and stem cell biology to develop innovative technologies for a sustainable livestock production.

Call for proposal

H2020-FETOPEN-2018-2020

See other projects for this call

Sub call

H2020-FETOPEN-2018-2019-2020-01

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITA DEGLI STUDI DI MILANO
Net EU contribution
€ 616 250,00
Address
Via Festa Del Perdono 7
20122 Milano
Italy
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (5)

ISRAEL OCEANOGRAPHIC AND LIMNOLOGICAL RESEARCH LIMITED
Israel
Net EU contribution
€ 554 025,00
Address
Tel Shikmona
31080 Haifa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 445 625,00
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
BIOFABICS LDA
Portugal
Net EU contribution
€ 492 500,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Rua Alfredo Allen 455/461
4200-135 Porto
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Continente Norte Área Metropolitana do Porto
 
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
Net EU contribution
€ 516 250,00
Address
Universitetstunet 3
1433 As
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SKRETTING AQUACULTURE RESEARCH CENTRE AS
Norway
Net EU contribution
€ 374 000,00
Address
Po Box 319
4016 Stavanger
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Norge Vestlandet Rogaland