Skip to main content

Photonic and nAnomeTric High-sensitivity biO-Sensing

Objective

We plan to develop a radically new technology for the sensing of bio-systems and in-vivo diagnostics of biomedical conditions using hitherto unexploited tools of unconventional complex-system dynamical control and information sampling/processing. They will be founded on groundbreaking concepts and challenging experiments, with the following aims: (a) Magnetic-resonance imaging (MRI) and optically-detected magnetic-resonance (ODMR) sensing will be dramatically improved by orders of magnitude through highly selective cooling/suppression of thermal noisy background in-vivo with unprecedented spectral and spatial (subnano- or submicron-) resolution. It will be based on so far unemployed (but conceptually proven) stochastic (anti-) Zeno effects and collective-spin cooling pioneered by the partners of this very interdisciplinary consortium. (b) Development of novel probing configurations and protocols: NMR intra-molecule/intra-tissue sensing and intra-cell NV-center thermometry based on dynamical control being aimed at unravelling of hitherto invisible biochemical activity features masked by inhomogeneous broadening. (c) Advanced sensing-data processing, including high-order correlation spectroscopy – innovative strategies that seek to exploit dynamically controlled/modified noise in bio-systems as a source of previously untapped information on physiological (temporal) processes and anatomical (structural) detail. This information will be obtained by treating bio-systems as complex, noisy “environments” through novel probing/estimation procedures and compressed (sparse) imagery of the spectrally and spatially structured “environment”, but reducing drastically their complexity by dynamically controlling the relevant information encoded by key noise parameters. The overarching goal will be to substantially enrich the spatial and spectral information content and robustness of diverse medical diagnostic procedures and thereby minimize the exposure time/irradiation dosage.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITA DEGLI STUDI DI FIRENZE
Address
Piazza San Marco 4
50121 Florence
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 536 250

Participants (4)

ISTITUTO NAZIONALE DI RICERCA METROLOGICA
Italy
EU contribution
€ 506 250
Address
Strada Delle Cacce 91
10135 Torino
Activity type
Research Organisations
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 500 000
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 512 500
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAT DORTMUND
Germany
EU contribution
€ 512 500
Address
August Schmidt Strasse 4
44227 Dortmund
Activity type
Higher or Secondary Education Establishments