Project description
Identifying reasons for patients’ negative response to treatment
The identification of the molecular mechanisms that can positively or negatively influence a patient’s response to medical treatment is a key issue among health practitioners. A study promoted by 3TR, a consortium of university institutions, SMEs and leading pharmaceutical companies, will address this issue. This EU-funded project will apply bioinformatics and control methods to collect and analyse data from blood, tissues and other fluids during the entire treatment process. It will create a centralised data platform for better management and implement an inclusive molecular and clinical picture of patients experiencing similar diseases. The project intends to explain the role that our microbiome, genetics and regulatory genomics play during treatment.
Objective
3TR is a transdisciplinary consortium made of experts in all areas of medicine, basic sciences and bioinformatics from academic institutions, SMEs, and 8 major pharmaceutical companies, teamed to study a fundamental issue in medicine: the mechanisms of response and non-response to therapies, the major aim of 3TR, both within single disease entities and across diseases, where molecular stratification may identify shared disease taxonomies. The molecular identification of groups of patients to whom a drug will benefit, will allow focusing on those who are drug orphan. Harmonization of data from existing academy or industry-sponsored studies will identify biomarkers to inform a new collection. Specimens of diseased tissues, blood, stools, and other fluids will be obtained in a de novo observational prospective trial with standard of care medication prior, during and after first or second line of treatment. Because the studies will be at different phases of progression, a carrousel model of work was designed for input and output of data to be continuously analysed, and interpreted, to inform those measurements to be undertaken and allow cross-validation of results. The 3TR team will elucidate the role of the microbiome, genetics and regulatory genomic features in disease progression. The working aims of 3TR are: 1) establish a centralized data management platform; 2) perform comprehensive molecular and clinical characterisation of a prospective patient cohort; 3) establish integrated analysis of all data using advanced bioinformatics/statistical and modelling methods; 4) identify sets of predictive biomarkers of response/non-response to therapies; 5) improve the competitiveness of European industry and support development of novel solutions. 3TR will sustain beyond the project end the samples and its knowledge base. 3TR will challenge and revolutionize the conventional single-disease based approach with important implications in future disease treatment.
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Keywords
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Funding Scheme
RIA - Research and Innovation actionCoordinator
41092 Sevilla
Spain
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Participants (85)
M13 9PL Manchester
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24118 Kiel
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LE1 7RH Leicester
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
LE1 5WW Leicester
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66386 St Ingbert
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08003 Barcelona
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1003 Lausanne
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20122 Milano
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9713 GZ Groningen
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12489 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
28001 Madrid
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
35128 Padova
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50139 Firenze
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9000 Gent
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3400 Hillerod
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54035 Nancy Cedex
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G12 8QQ Glasgow
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G12 0XH Glasgow
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10117 Berlin
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28006 Madrid
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08036 Barcelona
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08036 Barcelona
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28029 Madrid
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10117 Berlin
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1000 BRUXELLES
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S10 2PX Sheffield
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31000 OSIJEK
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SW7 2AZ LONDON
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75654 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
91190 Gif-Sur-Yvette
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1649 028 Lisboa
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17177 Stockholm
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
104 22 Stockholm
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1000 Bruxelles / Brussel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
80539 Munchen
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30625 Hannover
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70182 Orebro
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701 16 Orebro
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CB4 0GA Cambridge
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
35037 Marburg
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E1 4NS London
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41071 Sevilla
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
29590 MALAGA
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Participation ended
04700 El Ejido Almeria
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14004 Cordoba
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18014 Granada
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28046 MADRID
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
28040 Madrid
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20124 Milano
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
75006 Paris
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1081 HV Amsterdam
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01069 Dresden
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CB2 1TN Cambridge
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
CB2 0QQ Cambridge
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BT7 1NN Belfast
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95131 Catania
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13100 Vercelli
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09124 Cagliari
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16126 Genova
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56126 Pisa
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4051 Basel
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
4031 Basel
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1200 Bruxelles / Brussel
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29238 BREST
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
29609 Brest
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3500 Hasselt
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5020 Bergen
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
5021 Bergen
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4 Dublin
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WC1E 6BT London
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3000 Leuven
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SO17 1BJ Southampton
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90419 Lodz
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9052 ZWIJNAARDE - GENT
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65929 Frankfurt Am Main
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2340 Beerse
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Participation ended
WC2B 4AE London
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151 85 Sodertaelje
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TW89GS Brentford
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4056 Basel
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CT13 9NJ Sandwich
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4070 Basel
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8152 Glattpark
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10154 New York
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08028 Barcelona
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