Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Health and Huntington’s Disease

Project Information

FUELING-TRANSPORT

Grant agreement ID: 834317

DOI

10.3030/834317

Project closed

EC signature date 10 September 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 369 941,00

EU contribution

€ 2 369 941,00

Coordinated by

UNIVERSITE GRENOBLE ALPES
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data managment plan

ORDP

Publications

Peer reviewed articles (7)

Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning

Author(s): Hélène Vitet, Julie Bruyère, Hao Xu, Claire Séris, Jacques Brocard, Yah-Sé Abada, Benoît Delatour, Chiara Scaramuzzino, Laurent Venance, Frédéric Saudou
Published in: eLife, Issue 12, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.81011

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

Author(s): Sophie Lenoir, Aurélie Genoux, Fabienne Agasse, Frédéric Saudou, Sandrine Humbert
Published in: STAR Protocols, Issue 2, 2021, Page(s) 100382, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100382

Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities

Author(s): Anthony Procès, Yeranddy A. Alpizar, Sophie Halliez, Bert Brône, Frédéric Saudou, Laurence Ris, Sylvain Gabriele
Published in: Biomaterials, Issue 305, 2024, Page(s) 122426, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122426

A vesicular <scp>Warburg</scp> effect: Aerobic glycolysis occurs on axonal vesicles for local <scp>NAD+</scp> recycling and transport

Author(s): Maximilian Mc Cluskey, Hervé Dubouchaud, Anne‐Sophie Nicot, Frédéric Saudou
Published in: Traffic, Issue 25, 2024, Page(s) e12926, ISSN 1398-9219
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tra.12926

Traffic signaling: new functions of huntingtin and axonal transport in neurological disease

Author(s): Hélène Vitet, Vicky Brandt, Frédéric Saudou
Published in: Current Opinion in Neurobiology, Issue 63, 2020, Page(s) 122-130, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2020.04.001

Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus

Author(s): Chiara Scaramuzzino, Emeline C. Cuoc, Patrick Pla, Sandrine Humbert, Frédéric Saudou
Published in: Science Advances, Issue 8, 2024, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.abj8812

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Author(s): Stephen C. Cunnane, Eugenia Trushina, Cecilie Morland, Alessandro Prigione, Gemma Casadesus, Zane B. Andrews, M. Flint Beal, Linda H. Bergersen, Roberta D. Brinton, Suzanne de la Monte, Anne Eckert, Jenni Harvey, Ross Jeggo, Jack H. Jhamandas, Oliver Kann, Clothide Mannoury la Cour, William F. Martin, Gilles Mithieux, Paula I. Moreira, Michael P. Murphy, Klaus-Armin Nave, Tal Nuriel, Stéphane H.
Published in: Nature Reviews Drug Discovery, Issue 19/9, 2020, Page(s) 609-633, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-020-0072-x