Tension of ENDOmembranes maintained by TORC1

Project Information

TENDO

Grant agreement ID: 834394

DOI 10.3030/834394

Project closed

EC signature date 18 April 2019

Start date 1 May 2019

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 257 546,00

EU contribution € 2 257 546,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance

Author(s): Margot Riggi, Beata Kusmider, Robbie Loewith
Published in: Journal of Cell Science, Issue 133/9, 2020, Page(s) jcs242040, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.242040

Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity

Author(s): Javier Collado, Maria Kalemanov, Felix Campelo, Clélia Bourgoint, Ffion Thomas, Robbie Loewith, Antonio Martínez-Sánchez, Wolfgang Baumeister, Christopher J. Stefan, Rubén Fernández-Busnadiego
Published in: Developmental Cell, Issue 51/4, 2019, Page(s) 476-487.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.10.018

EGOC inhibits TOROID polymerization by structurally activating TORC1

Author(s): Manoël Prouteau, Clélia Bourgoint, Jan Felix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas N. Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
Published in: Nature Structural & Molecular Biology, Issue 30, 2023, Page(s) 273-285, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00912-6

TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast

Author(s): Oliver Schmidt, Yannick Weyer, Simon Sprenger, Michael A. Widerin, Sebastian Eising, Verena Baumann, Mihaela Angelova, Robbie Loewith, Christopher J. Stefan, Michael W. Hess, Florian Fröhlich, David Teis
Published in: Journal of Biological Chemistry, Issue 295/34, 2020, Page(s) 12028-12044, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013222

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9

Author(s): Michael Plank, Mariya Perepelkina, Markus Müller, Stefania Vaga, Xiaoming Zou, Clélia Bourgoint, Marina Berti, Jacques Saarbach, Steven Haesendonckx, Nicolas Winssinger, Ruedi Aebersold, Robbie Loewith
Published in: Molecular & Cellular Proteomics, Issue 19/4, 2020, Page(s) 655-671, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.001955

The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast

Author(s): Nataliia Serbyn, Audrey Noireterre, Ivona Bagdiul, Michael Plank, Agnès H. Michel, Robbie Loewith, Benoît Kornmann, Françoise Stutz
Published in: Molecular Cell, Issue 77/5, 2020, Page(s) 1066-1079.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.12.007

Structural Insights into TOR Signaling

Author(s): Lucas Tafur, Jennifer Kefauver, Robbie Loewith
Published in: Genes, Issue 11/8, 2020, Page(s) 885, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11080885

Sphingolipids and membrane targets for therapeutics

Author(s): Robbie Loewith, Howard Riezman, Nicolas Winssinger
Published in: Current Opinion in Chemical Biology, Issue 50, 2019, Page(s) 19-28, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2019.02.015

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain

Author(s): Jennifer M. Kefauver, Markku Hakala, Luoming Zou, Josephine Alba, Javier Espadas, Maria G. Tettamanti, Jelena Gajić, Caroline Gabus, Pablo Campomanes, Leandro F. Estrozi, Nesli E. Sen, Stefano Vanni, Aurélien Roux, Ambroise Desfosses, Robbie Loewith
Published in: Nature, Issue 632, 2024, Page(s) 664-671, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07720-6

TORC2 controls endocytosis through plasma membrane tension

Author(s): Margot Riggi Clélia Bourgoint Mariano Macchione Stefan Matile Robbie Loewith, Aurélien Roux
Published in: The Journal of Cell Biology, 2019, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201901096

Non-peer reviewed articles (2)

Resolving the Communication GAPs Upstream of TORC1

Author(s): Robert Puschmann Robbie Loewith
Published in: Developmental Cell, 2020, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.10.007

TOR Signaling Is Going through a Phase

Author(s): Manoel Prouteau, Robbie Loewith
Published in: Cell Metabolism, Issue 29/5, 2019, Page(s) 1019-1021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.04.010