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Tension of ENDOmembranes maintained by TORC1

Project description

TOR proteins in the regulation of vacuolar membrane tension

The serine/threonine-protein kinase, TOR, is the target of the anti-fungal natural product rapamycin and exists in two complexes: TORC1 and TORC2. TORC1 is directly inhibited by rapamycin and plays important roles in biomass accumulation while TORC2 functions to maintain tension homeostasis of the plasma membrane. Researchers of the EU-funded TENDO project will develop novel chemical probes and use a broad methodological arsenal to investigate if and how TORC1 analogously senses and regulates tension of endomembranes. Moreover, they will study if and how TORC2 is regulated through formation of a helix-like structure upon glucose depletion as is the case for TORC1. This work will reveal new mechanisms of TOR regulation that may translate into therapeutic interventions.

Host institution

UNIVERSITE DE GENEVE
Net EU contribution
€ 2 257 546,00
Address
Rue Du General Dufour 24
1211 Geneve
Switzerland

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 2 257 546,00
Address
Rue Du General Dufour 24
1211 Geneve

See on map

Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00