Targeting RAS driven tumour immune evasion

Project Information

RASImmune

Grant agreement ID: 834692

DOI 10.3030/834692

EC signature date 7 June 2019

Start date 1 August 2019

End date 31 July 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

Author(s): J. Boumelha, S. de Carné Trécesson, E.K. Law, P. Romero-Clavijo, M.A. Coelho, K. Ng, E. Mugarza, C. Moore, S. Rana, D.R. Caswell, M. Murillo, D.C. Hancock, P.P. Argyris, W.L. Brown, C. Durfee, L.K. Larson, R.I. Vogel, A. Suárez-Bonnet, S.L. Priestnall, P. East, S.J. Ross, G. Kassiotis, M. Molina-Arcas, C. Swanton, R. Harris, J. Downward
Published in: Cancer Research, 2022, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-22-0325

Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in PTEN ‐null triple negative breast cancer

Author(s): Davide Zecchin, Christopher Moore, Fanourios Michailidis, Stuart Horswell, Sareena Rana, Michael Howell, Julian Downward
Published in: EMBO Molecular Medicine, Issue 12/8, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202011987

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Author(s): van Maldegem F, Valand K, Cole M, Patel H, Angelova M, Rana S, Colliver E, Enfield K, Bah N, Kelly G, Tsang VSK, Mugarza E, Moore C, Hobson P, Levi D, Molina-Arcas M, Swanton C, Downward J
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26214-x

Stratification method based on oncogenic RAS pathway activity predicts outcome in lung adenocarcinoma

Author(s): P. East, G.P. Kelly, D. Biswas, M. Marani, D.C. Hancock, C. Swanton, J. Downward, S. de Carné Trécesson
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33290-0

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets

Author(s): Rachel Cooley, Neesha Kara, Ning Sze Hui, Jonathan Tart, Chloë Roustan, Roger George, David C. Hancock, Brock F. Binkowski, Keith V. Wood, Mohamed Ismail, Julian Downward
Published in: Wellcome Open Research, Issue 5, 2020, Page(s) 20, ISSN 2398-502X
Publisher: Wellcome Trust
DOI: 10.12688/wellcomeopenres.15675.2

Immunotherapy boosts protective antibody responses against endogenous retroviruses in lung adenocarcinoma

Author(s): K.W. Ng, J. Boumelha, K.S.S. Enfield, J. Almagro, H. Cha, O. Pich, T. Karasaki, D.A. Moore, R. Salgado, M. Sivakumar, G. Young, M. Molina-Arcas, S. de Carné Trécesson, P. Anastasiou, A. Fendler, L. Au, S.T.C. Shepherd, C. Martínez-Ruiz, C. Puttick, J.R.M. Black, T.B.K. Watkins, H. Kim, S. Shim, N. Faulkner, J. Attig, S. Veeriah, N. Magno, S. Ward, A.M. Frankell, M. Al Bakir, E.L. Lim, M.S. Hill
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05771-9

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110alpha

Author(s): M. Ismail, S.R. Martin, R. George, F. Houghton, G. Kelly, R.A.G. Chaleil, P. Anastasiou, X. Wang, N. O’Reilly, S. Federico, D. Joshi, H. Nagaraj, R. Cooley, N.S. Hui, M. Molina-Arcas, D.C. Hancock, A. Tavassoli, J. Downward
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-28756-0

Micro-CT image acquisition, processing, and segmentation to track lung cancer progression and characterise pulmonary nodules in mice

Author(s): M.Z. Thin, C. Moore, T. Snoeks, T. Kalber, J. Downward, A. Behrens
Published in: Nature Protocols, 2022, ISSN 1750-2799
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-022-00769-5

Lung adenocarcinoma promotion by air pollutants

Author(s): W. Hill, E.L. Lim, C.E. Weeden, C. Lee, M. Augustine, K. Chen, F-C. Kuan, F. Marongiu, E.J. Evans Jr, D.A. Moore, F.S. Rodrigues, O. Pich, B. Bakker, H. Cha, R. Myers, F. van Maldegem, J. Boumelha, S. Veeriah, A. Rowan, C. Naceur-Lombardelli, T. Karasaki, M. Sivakumar, S. De, D.R. Caswell, A. Nagano, J.R.M. Black, C. Martínez-Ruiz, M.H. Ryu, R.D. Huff, S. Li, M-J. Favé, A. Magness, A. Suárez-Bo
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05874-3

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

Author(s): E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. Llorian Sopena, P. East, R. Ambler, P. Anastasiou, P. Romero Clavijo, K. Valand, M. Cole, M. Molina-Arcas, J. Downward
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abm8780

Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis

Author(s): G. Tomić, C. Sheridan, A. Refermat, M. Baggelaar, J. Sipthorp, B. Sudarshan, C.A. Ocasio, A. Suarez-Bonnet, S. Priestnall, E. Herbert, E. Tate, J. Downward
Published in: Cell Reports, 2024, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.114224

In vivo CRISPR screen identifies KRAS-induced COX-2 as a driver of immune evasion and immunotherapy resistance in lung cancer

Author(s): J. Boumelha, A. de Castro, N. Bah, H. Cha, S. de Carné Trécesson, S. Rana, P. Anastasiou, E. Mugarza, C. Moore, R. Goldstone, P. East, K. Litchfield, S-H. Lee, M. Molina-Arcas, J. Downward
Published in: Cancer Research, 2024, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-23-2627

Other (2)

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

Author(s): Panayiotis Anastasiou, Chris Moore, Sareena Rana, Andrea de Castro, Mona Tomaschko, Jesse Boumelha, Edurne Mugarza, Cristina Blaj, Sophie de Carné, Robert Goldstone, Jacqueline A.M. Smith, Elsa Quintana, Miriam Molina-Arcas, Julian Downward
Published in: 2024
Publisher: Cold Spring Harbor Press
DOI: 10.1101/2024.01.15.575765

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

Author(s): Megan Cole, Panayiotis Anastasiou, Claudia Lee, Chris Moore, Edurne Mugarza, Martin Jones, Karishma Valand, Sareena Rana, Emma Colliver, Mihaela Angelova, Katey S.S. Enfield, Alastair Magness, Asher Mullokandov, Gavin Kelly, Tanja D. de Gruijl, Miriam Molina-Arcas, Charles Swanton, View ORCID ProfileJulian Downward, Febe van Maldegem
Published in: 2024
Publisher: Cold Spring Harbor Press
DOI: 10.1101/2024.04.11.588725