Skip to main content

The role of damage-induced non coding RNA in the control of DNA damage response activation at telomeres in aging

Publications

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Author(s): Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson, Fabrizio d’Adda di Fagagna
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13018-3

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Author(s): Raffaella Di Micco, Valery Krizhanovsky, Darren Baker, Fabrizio d’Adda di Fagagna
Published in: Nature Reviews Molecular Cell Biology, 22/2, 2021, Page(s) 75-95, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-00314-w

Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR

Author(s): Ilaria Rosso, Fabrizio d’Adda di Fagagna
Published in: International Journal of Molecular Sciences, 21/24, 2020, Page(s) 9774, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249774

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

Author(s): Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia, Valerio Vitelli, Alessandro Galbiati, Sara Barozzi, Massimiliano Garre, Amanda Oldani, Andrew Flaus, Roberto Cerbino, Dario Parazzoli, Eli Rothenberg, Fabrizio d’Adda di Fagagna
Published in: Nature Cell Biology, 21/10, 2019, Page(s) 1286-1299, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-019-0392-4

Telomere transcription in ageing

Author(s): Julio Aguado, Fabrizio d’Adda di Fagagna, Ernst Wolvetang
Published in: Ageing Research Reviews, 62, 2020, Page(s) 101115, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2020.101115

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

Author(s): Sheetal Sharma, Roopesh Anand, Xuzhu Zhang, Sofia Francia, Flavia Michelini, Alessandro Galbiati, Hannah Williams, Daryl A. Ronato, Jean-Yves Masson, Eli Rothenberg, Petr Cejka, Fabrizio d’Adda di Fagagna
Published in: Cell Reports, 34/1, 2021, Page(s) 108565, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108565

DNA Damage Triggers a New Phase in Neurodegeneration

Author(s): Fabio Pessina, Ubaldo Gioia, Ornella Brandi, Stefania Farina, Marta Ceccon, Sofia Francia, Fabrizio d’Adda di Fagagna
Published in: Trends in Genetics, 37/4, 2021, Page(s) 337-354, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2020.09.006

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

Author(s): Matteo Cabrini, Marco Roncador, Alessandro Galbiati, Lina Cipolla, Antonio Maffia, Fabio Iannelli, Simone Sabbioneda, Fabrizio d’Adda di Fagagna, Sofia Francia
Published in: Journal of Cell Science, 134/6, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.249706