The role of damage-induced non coding RNA in the control of DNA damage response activation at telomeres in aging

Project Information

TeloRNAging

Grant agreement ID: 835103

DOI

10.3030/835103

Project closed

EC signature date 13 May 2019

Start date 1 October 2019

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 497 500,00

EU contribution

€ 2 497 500,00

Coordinated by

IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Author(s): Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson, Fabrizio d’Adda di Fagagna
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13018-3

Guidelines for minimal information on cellular senescence experimentation in vivo

Author(s): Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D. Adams, Fabrizio d’Adda di Fagagna, Darren J. Baker, Cleo L. Bishop, Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber, Eiji Hara, Pidder Jansen-Dürr, Diana Jurk, Sundeep Khosla, James L. Kirkland, Valery Krizhanovsky, Tohru Minamino, Laura J. Niedernhofer, João F. Passos, Nadja A.R. Ring, Heinz Redl, Paul D. Robbins, Fra
Published in: Cell, Issue 187, 2024, Page(s) 4150-4175, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.05.059

SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

Author(s): Ubaldo Gioia, Sara Tavella, Pamela Martínez-Orellana, Giada Cicio, Andrea Colliva, Marta Ceccon, Matteo Cabrini, Ana C. Henriques, Valeria Fumagalli, Alessia Paldino, Ettore Presot, Sreejith Rajasekharan, Nicola Iacomino, Federica Pisati, Valentina Matti, Sara Sepe, Matilde I. Conte, Sara Barozzi, Zeno Lavagnino, Tea Carletti, Maria Concetta Volpe, Paola Cavalcante, Matteo Iannacone, Chiara Rampa
Published in: Nature Cell Biology, Issue 25, 2023, Page(s) 550-564, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-023-01096-x

Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer

Author(s): Emanuela Frittoli, Andrea Palamidessi, Fabio Iannelli, Federica Zanardi, Stefano Villa, Leonardo Barzaghi, Hind Abdo, Valeria Cancila, Galina V. Beznoussenko, Giulia Della Chiara, Massimiliano Pagani, Chiara Malinverno, Dipanjan Bhattacharya, Federica Pisati, Weimiao Yu, Viviana Galimberti, Giuseppina Bonizzi, Emanuele Martini, Alexander A. Mironov, Ubaldo Gioia, Flora Ascione, Qingsen Li, Kristin
Published in: Nature Materials, Issue 22, 2024, Page(s) 644-655, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-022-01431-x

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Author(s): Raffaella Di Micco, Valery Krizhanovsky, Darren Baker, Fabrizio d’Adda di Fagagna
Published in: Nature Reviews Molecular Cell Biology, Issue 22/2, 2021, Page(s) 75-95, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-00314-w

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

Author(s): Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio, Fabrizio d’Adda di Fagagna
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42831-0

Telomere dysfunction in ageing and age-related diseases

Author(s): Francesca Rossiello, Diana Jurk, João F. Passos & Fabrizio d’Adda di Fagagna
Published in: Nature Cell Biology, 2022, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00842-x

Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR

Author(s): Ilaria Rosso, Fabrizio d’Adda di Fagagna
Published in: International Journal of Molecular Sciences, Issue 21/24, 2020, Page(s) 9774, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249774

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

Author(s): Francesco Napoletano, Gloria Ferrari Bravo, Ilaria Anna Pia Voto, Aurora Santin, Lucia Celora, Elena Campaner, Clara Dezi, Arianna Bertossi, Elena Valentino, Mariangela Santorsola, Alessandra Rustighi, Valentina Fajner, Elena Maspero, Federico Ansaloni, Valeria Cancila, Cesare Fabio Valenti, Manuela Santo, Osvaldo Basilio Artimagnella, GianninoDel Sal
Published in: Cell reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109694

Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)

Author(s): Marta Falcinelli, Giulia Dell’Omo, Elena Grassi, Elisa Mariella, Simonetta Maria Leto, Sharon Scardellato, Annalisa Lorenzato, Sabrina Arena, Andrea Bertotti, Livio Trusolino, Alberto Bardelli, Fabrizio d’Adda di Fagagna
Published in: Cell Death & Disease, Issue 14, 2024, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-023-05640-3

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

Author(s): Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia, Valerio Vitelli, Alessandro Galbiati, Sara Barozzi, Massimiliano Garre, Amanda Oldani, Andrew Flaus, Roberto Cerbino, Dario Parazzoli, Eli Rothenberg, Fabrizio d’Adda di Fagagna
Published in: Nature Cell Biology, Issue 21/10, 2019, Page(s) 1286-1299, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-019-0392-4

Telomere transcription in ageing

Author(s): Julio Aguado, Fabrizio d’Adda di Fagagna, Ernst Wolvetang
Published in: Ageing Research Reviews, Issue 62, 2020, Page(s) 101115, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2020.101115

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging.

Author(s): Sepe, S.; Rossiello, F.; Cancila, V.; Iannelli, F.; Matti, V.; Cicio, G.; Cabrini, M.; Marinelli, E.; Alabi, B. R.; di Lillo, A.; Di Napoli, A.; Shay, J. W.; Tripodo, C.; d' Adda di Fagagna, F.
Published in: EMBO Reports, Issue 2, 2022, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202153658

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

Author(s): Sheetal Sharma, Roopesh Anand, Xuzhu Zhang, Sofia Francia, Flavia Michelini, Alessandro Galbiati, Hannah Williams, Daryl A. Ronato, Jean-Yves Masson, Eli Rothenberg, Petr Cejka, Fabrizio d’Adda di Fagagna
Published in: Cell Reports, Issue 34/1, 2021, Page(s) 108565, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108565

BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1

Author(s): Dan Chen, Judit Z. Gervai, Ádám Póti, Eszter Németh, Zoltán Szeltner, Bernadett Szikriszt, Zsolt Gyüre, Judit Zámborszky, Marta Ceccon, Fabrizio d’Adda di Fagagna, Zoltan Szallasi, Andrea L. Richardson, and Dávid Szüts
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27872-7

DNA Damage Triggers a New Phase in Neurodegeneration

Author(s): Fabio Pessina, Ubaldo Gioia, Ornella Brandi, Stefania Farina, Marta Ceccon, Sofia Francia, Fabrizio d’Adda di Fagagna
Published in: Trends in Genetics, Issue 37/4, 2021, Page(s) 337-354, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2020.09.006

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

Author(s): Matteo Cabrini, Marco Roncador, Alessandro Galbiati, Lina Cipolla, Antonio Maffia, Fabio Iannelli, Simone Sabbioneda, Fabrizio d’Adda di Fagagna, Sofia Francia
Published in: Journal of Cell Science, Issue 134/6, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.249706