Deciphering the molecular mechanisms of HIV DNA nuclear import and the impact of 3D genome organization on integration site selection

Project Information

RetroChrom

Grant agreement ID: 835184

DOI

10.3030/835184

Project closed

EC signature date 7 June 2019

Start date 1 September 2019

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Unintegrated HIV-1 DNA recruits cGAS via its histone-binding domain to escape innate immunity

Author(s): Cyprien Jahan, Lucie Bonnet-Madin, Shinichi Machida, Bijan Sobhian, Suzie Thenin-Houssier, Monsef Benkirane
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2424465122

POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing

Author(s): Suzie Thenin-Houssier, Shinichi Machida, Cyprien Jahan, Lucie Bonnet-Madin, Scarlette Abbou, Heng-Chang Chen, Robel Tesfaye, Olivier Cuvier, Monsef Benkirane
Published in: Science Advances, Issue 9, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science’s
DOI: 10.1126/sciadv.adh3642

Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome

Author(s): Shinichi Machida, David Depierre, Heng-Chang Chen, Suzie Thenin-Houssier, Gaël Petitjean, Cecile M. Doyen, Motoki Takaku, Olivier Cuvier, Monsef Benkirane
Published in: Proceedings of the National Academy of Sciences, Issue 117/12, 2020, Page(s) 6822-6830, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1913754117

Faithful to the Marseille tradition: Unique and intriguing—that’s how Marseillevirus packs its DNA

Author(s): Shinichi Machida, Joao Diogo Dias, Monsef Benkirane
Published in: Molecular Cell, Issue 82, 2024, Page(s) 4401-4402, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.11.001

Condensates, the place to hide self-immunostimulatory RNA

Author(s): Monsef Benkirane
Published in: Molecular Cell, Issue 82, 2024, Page(s) 3754-3755, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.09.028

Other (1)

Combined direct/indirect detection allows identification of DNA termini in diverse sequencing datasets and supports a multiple-initiation-site model for HIV plus-strand synthesis

Author(s): William Wang, Karen L. Artiles, Shinichi Machida, Monsef Benkirane, Nimit Jain, Andrew Z. Fire
Published in: BioRix, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.12.544617