Schwann Cell Options for chronic Pain Eradication

Project Information

SCOPE

Grant agreement ID: 835286

DOI

10.3030/835286

Project closed

EC signature date 20 May 2019

Start date 1 September 2019

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 185 921,00

EU contribution

€ 2 185 921,00

Coordinated by

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief

Author(s): Luigi F. Iannone; Romina Nassini; Riccardo Patacchini; Pierangelo Geppetti; Francesco De Logu
Published in: Temperature, Issue 23328940, 2022, ISSN 2332-8940
Publisher: Routledge
DOI: 10.1080/23328940.2022.2075218

Schwann cell insulin-like growth factor receptor type-1 mediates metastatic bone cancer pain in mice

Author(s): Lorenzo Landini, Matilde Marini, Daniel Souza Monteiro de Araujo, Antonia Romitelli, Marco Montini, Valentina Albanese, Mustafa Titiz, Alessandro Innocenti, Francesca Bianchini, Pierangelo Geppetti, Romina Nassini, Francesco De Logu
Published in: Brain Behav Immun, Issue 8, 2023, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2023.03.013

Pain Signaling by GPCRs and RTKs

Author(s): Brain L. Schmidt, Francesco De Logu, Romina Nassini, Pierangelo Geppetti, Nigel W. Bunnett
Published in: Trends in Pharmacological Sciences, 2025, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2025.02.002

Schwann cell TRPA1 elicits reserpine‐induced fibromyalgia pain in mice

Author(s): Evelyne Silva Brum, Maria Fernanda Pessano Fialho, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Matilde Marini, Mustafa Titiz, Bruna Luiza Kuhn, Clarissa Piccinin Frizzo, Pedro Henrique Silva Araújo, Rafaela Mano Guimarães, Thiago Mattar Cunha, Cássia Regina Silva, Gabriela Trevisan, Pierangelo Geppetti, Romina Nassini, Francesco De Logu, Sara Marchesan Oliveira
Published in: British Journal of Pharmacology, Issue 181, 2024, Page(s) 3445-3461, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.16413

Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

Author(s): Mustafa Titiz, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Matilde Marini, Viola Seravalli, Martina Chieca, Pasquale Pensieri, Marco Montini, Gaetano De Siena, Benedetta Pasquini, Silvia Vannuccini, Luigi Francesco Iannone, Thiago M. Cunha, Giulia Brancolini, Elisa Bellantoni, Irene Scuffi, Alessandra Mastricci, Martina Tesi, Mariarosaria Di Tommaso, Felice Petraglia, Pierangelo Geppetti, Ro
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54486-6

Transient receptor potential ankyrin 1 mediates headache-related cephalic allodynia in a mouse model of relapsing-remitting multiple sclerosis

Author(s): Diéssica P Dalenogare, Maria C Theisen, Diulle S Peres, Maria F P Fialho, Nathaly Andrighetto, Laura Barros, Lorenzo Landini, Mustafa Titiz, Francesco De Logu, Sara M Oliveira, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan
Published in: PAIN, Issue 0-0, 2021, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002520

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Author(s): Francesco De Logu, Romina Nassini, Alan Hegron, Lorenzo Landini, Dane D Jensen, Rocco Latorre, Julia Ding, Matilde Marini, Daniel Souza Monteiro de Araujo, Paulina Ramírez-Garcia, Michael Whittaker, Jeffri Retamal , Mustafa Titiz, Alessandro Innocenti, Thomas P Davis, Nicholas Veldhuis, Brian L Schmidt, Nigel W Bunnett, Pierangelo Geppetti
Published in: Nature Communications, Issue 13, 2022, Page(s) 646, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28204-z

Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain

Author(s): Francesco De Logu , Matilde Marini, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Niccolò Bartalucci, Gabriela Trevisan, Gennaro Bruno, Martina Marangoni, Brian L Schmidt, Nigel W Bunnett, Pierangelo Geppetti, Romina Nassini
Published in: Cancer Research, Issue 81, 2021, Page(s) 3387-3401, ISSN 1538-7445
Publisher: American Association for Cancer Research, Inc
DOI: 10.1158/0008-5472.can-20-3326

Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice

Author(s): Diéssica Padilha Dalenogare; Daniel Souza Monteiro de Araújo; Lorenzo Landini; Mustafa Titiz; Gaetano De Siena; Francesco De Logu; Pierangelo Geppetti; Romina Nassini; Gabriela Trevisan
Published in: Cells, Issue 1, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12111511

TRPA1 as a therapeutic target for nociceptive pain

Author(s): Daniel Souza Monteiro de Araujo, Romina Nassini, Pierangelo Geppetti, Francesco De Logu
Published in: Expert Opinion on Therapeutic Targets, Issue 24/10, 2020, Page(s) 997-1008, ISSN 1472-8222
Publisher: Ashley Publications Ltd.
DOI: 10.1080/14728222.2020.1815191

Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4

Author(s): Francesco De Logu, Gabriela Trevisan, Ilaria Maddalena Marone, Elisabetta Coppi, Diéssica Padilha Dalenogare, Mustafa Titiz, Matilde Marini, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Simone Li Puma, Serena Materazzi, Gaetano De Siena, Pierangelo Geppetti, Romina Nassini
Published in: BMC Biology, Issue 18/1, 2020, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-020-00935-9

Characterisation of periorbital mechanical allodynia in the reserpine-induced fibromyalgia model in mice: The role of the Schwann cell TRPA1/NOX1 signalling pathway

Author(s): Evelyne Silva Brum, Lorenzo Landini, Daniel Souza Monteiro de Araújo, Matilde Marini, Pierangelo Geppetti, Romina Nassini, Francesco De Logu, Sara Marchesan Oliveira
Published in: Free Radical Biology and Medicine, Issue 229, 2025, Page(s) 289-299, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2025.01.040

Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I

Author(s): Francesco De Logu, Samira Dal-Toé De Prá, Caren Tatiane de David Antoniazzi, Sabrina Qader Kudsi, Paula Ronsani Ferro, Lorenzo Landini, Flávia Karine Rigo, Gustavo de Bem Silveira, Paulo Cesar Lock Silveira, Sara Marchesan Oliveira, Matilde Marini, Gianluca Mattei, Juliano Ferreira, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan
Published in: Brain, Behavior, and Immunity, Issue 88, 2020, Page(s) 535-546, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2020.04.037

Non‐neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats

Author(s): De Logu, Francesco; De Siena, Gaetano; Landini, Lorenzo; Marini, Matilde; Souza Monteiro de Araujo, Daniel; Albanese, Valentina; Preti, Delia; Romitelli, Antonia; Chieca, Martina; Titiz, Mustafa; Iannone, Luigi F; Geppetti, Pierangelo; Nassini, Romina
Published in: Br J Pharmacol, Issue 1, 2023, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.16005

Periorbital Nociception in a Progressive Multiple Sclerosis Mouse Model Is Dependent on TRPA1 Channel Activation

Author(s): Diéssica Padilha Dalenogare, Camila Ritter, Fernando Roberto Antunes Bellinaso, Sabrina Qader Kudsi, Gabriele Cheiran Pereira, Maria Fernanda Pessano Fialho, Débora Denardin Lückemeyer, Caren Tatiane de David Antoniazzi, Lorenzo Landini, Juliano Ferreira, Guilherme Vargas Bochi, Sara Marchesan Oliveira, Francesco De Logu, Romina Nassini, Pierangelo Geppetti, Gabriela Trevisan
Published in: Pharmaceuticals (Basel), Issue 14, 2021, Page(s) 831, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14080831

Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine

Author(s): Landini, Lorenzo; Souza Monteiro de Araujo, Daniel; Chieca, Martina; De Siena, Gaetano; Bellantoni, Elisa; Geppetti, Pierangelo; Nassini, Romina; De Logu, Francesco
Published in: Journal of Biomedical Science, Issue 1, 2023, ISSN 1021-7770
Publisher: S. Karger AG
DOI: 10.1186/s12929-023-00922-6

TRPA1 Role in Inflammatory Disorders: What Is Known So Far?

Author(s): Lorenzo Landini , Daniel Souza Monteiro de Araujo, Mustafa Titiz, Pierangelo Geppetti, Romina Nassini, Francesco De Logu
Published in: Int J Mol Sci, Issue 16616596, 2022, Page(s) 4529, ISSN 1661-6596
Publisher: MDPI
DOI: 10.3390/ijms23094529

Non-peer reviewed articles (1)

Targeting the Schwann Cell EP2/cAMP Nanodomain to Block Pain but not Inflammation

Author(s): Romina Nassini, Lorenzo Landini, Matilde Marini, Martina Chieca, Daniel Souza Monteiro de Araujo, Marco Montini, Pasquale Pensieri, Vittorio Donato Abruzzese, Gaetano De Siena, Jin Zhang, Vincenzo De Giorgi, Antonia Romitelli, Giulia Brancolini, Raquel Tonello, Chloe J. Peach, Alessandra Mastricci, Irene Scuffi, Martina Tesi, Dane D. Jensen, Brian L. Schmidt, Nigel W. Bunnett, Francesco De Logu, P
Published in: BioRxiv, 2024
Publisher: BioRxiv
DOI: 10.1101/2024.09.10.612200