Deciphering and engineering centriole assembly

Project description

Uncovering the building principles behind nature's miniature Tower of Pisa

Centrioles are barrel-shaped organelles built on a complex yet highly stereotyped cartwheel-like structure with a hub and spokes. Centrioles are formed from nine circularly arranged microtubule triplets and are among the largest protein assemblies of eukaryotic cells. These billion-year-old organelles are highly conserved and essential for forming cilia as well as centrosomes, thereby playing a crucial role in motility and cell division. Understanding how centrioles assemble to form a functional organelle is a topic of great interest, and the EU-funded CENGIN project is probing and engineering the mechanisms governing assembly of proper centriole architecture.

Fields of science

Host institution

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Net EU contribution

€ 2 500 000,00

Address

Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland

Region

Schweiz/Suisse/Svizzera Région lémanique Vaud

Activity type

Higher or Secondary Education Establishments

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)