LYMPHIT: an innovative easy-to-use and cost-efficient diagnostic microneedle patch for the early detection of Lymphedema

Información del proyecto

Lymphit

Identificador del acuerdo de subvención: 836091

DOI

10.3030/836091

Proyecto cerrado

Fecha de la firma de la CE 19 Noviembre 2018

Fecha de inicio 1 Diciembre 2018

Fecha de finalización 31 Marzo 2019

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Coste total

€ 71 429,00

Aportación de la UE

€ 50 000,00

Coordinado por

DICRONIS SAGL
Switzerland

Periodic Reporting for period 1 - Lymphit (LYMPHIT: an innovative easy-to-use and cost-efficient diagnostic microneedle patch for the early detection of Lymphedema)

Período documentado: 2018-12-01 hasta 2019-03-31

Resumen del contexto y de los objetivos generales del proyecto

Lymphedema is a chronic condition which may be inherited (primary) or caused by injury to the lymphatic vessels (secondary). It is often-ignored and misunderstood condition but affects up to 250 million people throughout the world. Cancer survivors run a lifelong risk of secondary lymphedema, a disease with no known cure which is caused by damage to or removal of the lymph nodes because of surgery, chemotherapy and radiotherapy and characterized by swelling due to a marked accumulation of fluid in the limb. Although most cancer survivors developing secondary lymphoedema do so within the first three years following treatment, there is no standardized protocol for monitoring patients nor are there efficient, cost-effective methods for early detection of lymphedema. Diagnostic methods are highly inaccurate, can only detect the disease at an advanced and potentially irreversible stage, greatly decreasing patients’ quality-of-life and increasing healthcare costs. This project reviewed the technical and business feasibility of Lymphit. The first solution able to track the lymphatic activity and detect lymphedema at the earliest (sub-clinical) stage.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Dicronis completed a full analysis of the technical and business potential of their Lymphit technology. The project allowed Dicronis to formalize a sound technical development plan that forms the foundation for Lymphit’s commercialization. The next critical step for commercialization is to complete a period of clinical studies. This includes a first in-human study that will validate Lymphit’s ability to measure lymphatic activity and prove its safety. Following the study’s successful conclusion, Dicronis will conduct a larger clinical study which will enable commercialization of Lymphit as a diagnostic tool for lymphedema. During the project, Dicronis spoke to commercialization partners and discussed distribution of Lymphit following the completion of the clinical trials. Dicronis developed a go-to-market strategy with a European focus and investigated their internationalisation to the US and Japan.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Our innovative integrated system provides clinicians with a reliable, affordable diagnostic method to identify subclinical signs of lymphedema at least six months earlier than current diagnostic procedures. Lymphit reduces treatment costs by up to 50% by identifying the condition at a reversible stage. Medical practitioners can quickly and selectively prescribe conservative treatment, avoiding progression of the disease and enabling the patient to carry on everyday life as far as possible, thereby effecting a tenfold reduction in social costs associated with loss of productivity.

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Lymphedema external signs