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Engineering of complex protocells by micro-compartmentalization of living bacteria

Project description

Engaging bacteria in the creation of synthetic protocells

The engineering of artificial cellular systems with lifelike properties such as minimal metabolism, sensing, replication, gene expression and compartmentalisation represents an ideal strategy to understand the transition into proto-living manifestations of physical matter. The EU-funded PROTOBAC project aims to design a complex multi-component protocell based on the controlled sequestration and disruption of compartmentalised living bacterial colonies. The resulting protocells will be bound by an assemblage of bacterial membrane lipids and loaded with several functionally active metabolic and genetic components. The complexity of the bacteria-derived protocells will be increased via the introduction of biological organelles, which are expected to produce the first example of a protoeukaryote.


Net EU contribution
€ 212 933,76
Beacon House Queens Road
BS8 1QU Bristol
United Kingdom

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South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00