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Programmable NanoRobotics for Controlled Manipulation of Molecular Cargoes

Project description

Tiny robots that carry molecular cargos

Molecular machines are amongst the most complex functional molecules and govern nearly every biological process. The controlled manipulation of molecular-level structures through programmable small-molecule robotics could lead us towards the dawn of a new era of useful molecular nanotechnology. The EU-funded ProgNanoRobot project plans to construct artificial nanorobots that could transport a molecular cargo in a programmable fashion. The project will investigate methods for manipulating molecular fragments using a molecular robotic arm, find the best programmable small-molecule robotic systems and develop a toolbox of robotic machine components. This new generation of molecular robotics could aid the development of molecular-sized machines that can manipulate substrates to control sequence-specific oligomer construction and molecular manufacturing.

Objective

Molecular machines are among the most complex of all functional molecules and lie at the heart of nearly every biological process. The controlled manipulation of molecular-level structures through programmable small-molecule robotics is a fabulous challenge that could lead us towards the dawn of an era of useful molecular nanotechnology.
“ProgNanoRobot” project aims to design, construct and investigate the operation of artificial molecular nanorobots capable of transporting a molecule cargo in a programmable fashion. We will develop key methodologies needed to manipulate molecular fragments using a molecular robotic arm operating through the formation and cleavage of dynamic covalent bonds, building on a rotary switch in which the rotor and stator can be positioned with respect to each other. We will explore different component types to find the best programmable small-molecule robotic systems and develop a toolbox of robotic machine components. We will use them as the basis for molecular machines that can transport molecular cargoes of biological relevance over long distances and to select between different cargoes and move them between multiple sites on molecular platforms in either direction. Moreover, we will employ a chemical fuel that induces pH oscillations in the reaction medium to allow the autonomous operation of these systems, a key development to reach the full potential of molecular machines, which will enable them to work as effective molecular assembly lines.
We envisage that the domain of this new generation of molecular robotics will be useful for the development of molecular-sized machines that can manipulate substrates to control sequence-specific oligomer construction and molecular manufacturing.

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Topic(s)

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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

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(opens in new window) H2020-MSCA-IF-2018

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Coordinator

THE UNIVERSITY OF MANCHESTER
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 224 933,76
Address
OXFORD ROAD
M13 9PL Manchester
United Kingdom

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 224 933,76
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