Generation of ultra-deep libraries of transcriptional activators for gene therapy

Project description

A modular system for the production of transcriptional activators

Human gene therapy entails the administration of genetic material to alter the expression of or modify endogenous genes. In cases where activation of gene expression is required, researchers transfer transcription factors – proteins necessary for gene transcription – to the target cells. The EU-funded Diverge project has developed a modular system that combines site-specific recombinase and molecular splicing to generate billions of transcription factor variants in vivo from a single construct. Researchers are exploring the potential to commercialise this system and expand the applicability of the technology in therapy and biotechnology.

Fields of science

Host institution

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Net EU contribution

€ 150 000,00

Address

South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

Region

London Inner London — West Westminster

Activity type

Higher or Secondary Education Establishments

Links

Contact the organisation Website

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 0,00

Beneficiaries (1)