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Exhaustion-resistant CAR-T cells for the treatment of solid tumours

Project description

Overcoming poor CAR-T cell activity in solid tumours

T lymphocytes engineered to express chimeric antigen receptors (CAR) have shown promising results as an anti-cancer strategy against haematological malignancies. However, results against solid tumours are not satisfactory even though CAR-T cells infiltrate tumours efficiently. The EU-funded Exh-Res-CART project is examining the hypothesis that poor CAR-T cell activity in solid tumors is due to cell exhaustion in the tumour microenvironment. Using cutting-edge technologies, scientists will determine the mechanisms responsible for CAR-T cell unresponsiveness and design approaches to enhance the persistence and function of these cells in solid tumours.

Coordinator

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Net EU contribution
€ 160 932,48
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Other
Non-EU contribution
€ 0,00