Overcoming poor CAR-T cell activity in solid tumours
T lymphocytes engineered to express chimeric antigen receptors (CAR) have shown promising results as an anti-cancer strategy against haematological malignancies. However, results against solid tumours are not satisfactory even though CAR-T cells infiltrate tumours efficiently. The EU-funded Exh-Res-CART project is examining the hypothesis that poor CAR-T cell activity in solid tumors is due to cell exhaustion in the tumour microenvironment. Using cutting-edge technologies, scientists will determine the mechanisms responsible for CAR-T cell unresponsiveness and design approaches to enhance the persistence and function of these cells in solid tumours.