Role of neutrophils in the removal of necrotic DNA debris
The human body loses billions of cells a day due to the cell death process known as necrosis. Improper removal of cellular debris, such as DNA, is linked to conditions such as systemic lupus erythematosus, acute liver injury, atherosclerosis and severe trauma. Neutrophils, a subset of phagocytes, are good candidates for debris removal, but the mechanisms of necrotic DNA removal are currently unknown. The main objective of the EU-funded IMPACT project is to understand how neutrophils phagocytose and eliminate necrotic DNA debris.The project will test the hypothesis that neutrophils use complement receptors to bind and phagocytose complement-coated necrotic DNA.
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