The cDAC ERC Advanced project develops and validates a theory of consciousness and its application to the understanding and alleviation of its deficits. cDAC proposes that consciousness is a virtualization memory system that monitors and optimizes the real-time control of perception, cognition, and action realized in a multi-layered architecture. Building on cDAC, we have advanced and validated new concepts and methods for the diagnostics and treatment of cognitive and affective deficits post-stroke. The PoC project propelled these interventions into the real world by integrating them with the Rehabilitation Gaming System (RGS), creating cRGS to address the need for novel neurorehabilitation solutions to overcome the limitations of the current healthcare system. Within this project, we have developed the RGS ecosystem which includes the solutions RGS@clinic, RGS@home, RGSwear, and the Medical Information Management System (MIMS), and optimized it according to the feedback received by primary and secondary users. We also developed evaluation and training scenarios that adhere to the principles of neurorehabilitation as outlined in the proposal. We have successfully designed and launched a randomized clinical trial in Spain which aims to validate the acceptability and cost-effectiveness of the RGS ecosystem as a combined therapy. In collaboration with Hospital San Joan de Deu, an ethical approval has been obtained. 25 patients have been recruited and are currently using the RGS@Home and the RGS-Wear systems daily. We have conducted a preliminary analysis of the systems' recordings to derive and validate meaningful indicators of usability and adherence. Due to the current COVID crisis, the study did not conclude yet but is prospected to continue for another year after which we will be able to determine the performance and recovery of the patients included in the study. To transition the project into a viable product a detailed analysis of the predicted impact on sales volumes for the next 7 years, a profound risk assessment of the project and a return on investment (ROI) analysis have been executed. Finally, we have engaged in numerous communication and educational activities, including the development and evaluation of an education platform with the objective of bringing awareness to the challenges and benefits of technology-based application for better health and the shift towards a value-based healthcare model.
