Enhancing brown adipose tissue through NAD+ precursors: a new approach to treat cardiometabolic disease

Project Information

eBAT

Grant agreement ID: 840110

DOI 10.3030/840110

Project closed

EC signature date 10 April 2019

Start date 1 June 2019

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 175 572,48

EU contribution € 175 572,48

Coordinated by

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

Publications

Peer reviewed articles (6)

Reduced nicotinamide mononucleotide is a new and potent NAD + precursor in mammalian cells and mice

Author(s): Rubén Zapata‐Pérez, Alessandra Tammaro, Bauke V. Schomakers, Angelique M. L. Scantlebery, Simone Denis, Hyung L. Elfrink, Judith Giroud‐Gerbetant, Carles Cantó, Carmen López‐Leonardo, Rebecca L. McIntyre, Michel van Weeghel, Álvaro Sánchez‐Ferrer, Riekelt H. Houtkooper
Published in: The FASEB Journal, Issue 35/4, 2021, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202001826r

The first comprehensive phylogenetic and biochemical analysis of NADH diphosphatases reveals that the enzyme from Tuber melanosporum is highly active towards NAD+

Author(s): Antonio Ginés García-Saura, Rubén Zapata-Pérez, Ana Belén Martínez-Moñino, José Francisco Hidalgo, Asunción Morte, Manuela Pérez-Gilabert, Álvaro Sánchez-Ferrer
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-53138-w

A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

Author(s): Judith Giroud-Gerbetant, Magali Joffraud, Maria Pilar Giner, Angelique Cercillieux, Simona Bartova, Mikhail V. Makarov, Rubén Zapata-Pérez, José L. Sánchez-García, Riekelt H. Houtkooper, Marie E. Migaud, Sofia Moco, Carles Canto
Published in: Molecular Metabolism, Issue 30, 2019, Page(s) 192-202, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.09.013

NAD + homeostasis in human health and disease

Author(s): Rubén Zapata‐Pérez, Ronald J A Wanders, Clara D M Karnebeek, Riekelt H Houtkooper
Published in: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202113943

The female mouse is resistant to mild vitamin B3 deficiency

Author(s): Inge van der Stelt, Wenbiao Shi, Melissa Bekkenkamp-Grovenstein, Rubén Zapata-Pérez, Riekelt H. Houtkooper, Vincent C. J. de Boer, Maria A. Hegeman, Jaap Keijer
Published in: European Journal of Nutrition, 2021, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02651-8

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Author(s): Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen
Published in: The American Journal of Clinical Nutrition, Issue 112/2, 2020, Page(s) 413-426, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqaa072