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Enhancing brown adipose tissue through NAD+ precursors: a new approach to treat cardiometabolic disease

Project description

Fat cells recruited to fight cardiovascular disease

Hundreds of years ago, scientists discovered brown adipose tissue (BAT) in marmots. Since then, interest in BAT has waxed and waned. It was found in other mammals and even in new-born and infant children, and a metabolic role for BAT has solidified. Loaded with mitochondria, these specialised fat cells generate body heat, no shivering required. Discovery in adults a decade ago and a demonstrated role in insulin sensitivity have generated renewed interest in BAT as a therapeutic route to treatments for potentially fatal cardiometabolic disease. The eBAT project is studying a potentially very potent activator of BAT in cell lines and animal models, and as a dietary supplement.

Call for proposal

H2020-MSCA-IF-2018
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Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 175 572,48