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Control of Central Nervous Sytem inflammation by meningeal macrophages, and its impairment upon aging

Project description

The role of macrophages in CNS inflammation

The parenchyma of the central nervous system (CNS) contains membranes known as meninges, where macrophages reside. Emerging evidence indicates that these cells have the ability to detect microbes and recruit other immune cells to the CNS. The EU-funded MacMeninges project aims to study how these macrophages respond to microbial challenges and how they contribute to CNS inflammation, a potentially lethal condition. Using a combination of techniques, researchers will investigate the impact of ageing on CNS immune responses. Ultimately, the goal is to design interventions to restore meningeal immunity and treat neuroinflammation.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 146 227,04
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00

Participants (1)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Participation ended

France
Net EU contribution
€ 38 480,80
Address
Rue Michel Ange 3
75794 Paris
Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00