The role of macrophages in CNS inflammation
The parenchyma of the central nervous system (CNS) contains membranes known as meninges, where macrophages reside. Emerging evidence indicates that these cells have the ability to detect microbes and recruit other immune cells to the CNS. The EU-funded MacMeninges project aims to study how these macrophages respond to microbial challenges and how they contribute to CNS inflammation, a potentially lethal condition. Using a combination of techniques, researchers will investigate the impact of ageing on CNS immune responses. Ultimately, the goal is to design interventions to restore meningeal immunity and treat neuroinflammation.
Fields of science
Funding SchemeMSCA-IF-EF-RI - RI – Reintegration panel