Electrochemical Sulfonylation of Lysine Residues in Continuous Flow Microreactors.

Project description

A microreactor for novel peptide functionalisation could spur greener drug discovery

Site-selective modification of proteins or peptides has become a very common strategy to modulate protein function. Addition of a sulfonyl group to lysine, an amino acid that is a constituent of most proteins, is of growing interest to the research community as it could open the door to new possibilities for targeted therapies. Electrosynthesis, particularly for oxidation-reduction reactions involving electron transfer between species, has gained renewed attention as a greener synthesis method within the energy-intensive chemical industry. ELECTROSULF is exploiting the technology in a flow microreactor for oxidative sulfonylation of lysine, creating a new eco-friendly way to functionalise peptides and spur new drug discovery.

Fields of science

• natural sciences › chemical sciences › catalysis › photocatalysis
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs
• natural sciences › chemical sciences › electrochemistry › electrolysis
• natural sciences › biological sciences › biochemistry › biomolecules
• natural sciences › chemical sciences › organic chemistry › amines

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

TECHNISCHE UNIVERSITEIT EINDHOVEN

Net EU contribution

€ 175 572,48

Address

Groene Loper 3
5612 AE Eindhoven
Netherlands

Region

Noord-Brabant › Zuidoost-Noord-Brabant

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00