A microreactor for novel peptide functionalisation could spur greener drug discovery
Site-selective modification of proteins or peptides has become a very common strategy to modulate protein function. Addition of a sulfonyl group to lysine, an amino acid that is a constituent of most proteins, is of growing interest to the research community as it could open the door to new possibilities for targeted therapies. Electrosynthesis, particularly for oxidation-reduction reactions involving electron transfer between species, has gained renewed attention as a greener synthesis method within the energy-intensive chemical industry. ELECTROSULF is exploiting the technology in a flow microreactor for oxidative sulfonylation of lysine, creating a new eco-friendly way to functionalise peptides and spur new drug discovery.
Fields of science
- natural scienceschemical sciencescatalysisphotocatalysis
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical scienceselectrochemistryelectrolysis
- natural sciencesbiological sciencesbiochemistrybiomolecules
- natural scienceschemical sciencesorganic chemistryamines