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Electrochemical Sulfonylation of Lysine Residues in Continuous Flow Microreactors.

Project description

A microreactor for novel peptide functionalisation could spur greener drug discovery

Site-selective modification of proteins or peptides has become a very common strategy to modulate protein function. Addition of a sulfonyl group to lysine, an amino acid that is a constituent of most proteins, is of growing interest to the research community as it could open the door to new possibilities for targeted therapies. Electrosynthesis, particularly for oxidation-reduction reactions involving electron transfer between species, has gained renewed attention as a greener synthesis method within the energy-intensive chemical industry. ELECTROSULF is exploiting the technology in a flow microreactor for oxidative sulfonylation of lysine, creating a new eco-friendly way to functionalise peptides and spur new drug discovery.


Net EU contribution
€ 175 572,48
Groene Loper 3
5612 AE Eindhoven

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Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00