Project description
Neuromasts as a model to study regeneration mechanisms
Neuromasts are the mechanoreceptive organs that help fishes and amphibians sense mechanical water changes. Neuromasts contain hair cells that are similar to mammalian inner ear cells but are capable of regeneration. Understanding the mechanisms of the development and regeneration of these sensory organs may help treat deafness in humans. The EU-funded TFZN project will establish an in vitro neuromast model to investigate unanswered questions about organogenesis. Researchers will study triggers of cell proliferation during organ regeneration, stop signals of the proliferation process and determinants of organ architecture.
Objective
Neuromasts are the sensory organs used by fishes and amphibians to sense water displacement. Neuromasts contain hair cells that are very similar to our own inner ear cells. Unlike mammalian ear cells, bird and fish hair cells regenerate after ablated. Understanding the mechanisms responsible for the development and regeneration of the sensory organs holds the promise of treating deafness in humans. The study of neuromasts is also of advantage for basic science. With its three cell types, and 70 cells total, neuromasts are a relatively simple organ. They provide a good model to investigate unanswered questions about organogenesis: What makes cells proliferate during organ regeneration or development? What signals them to stop after normal organ size and cell number is reached? How is organ architecture – shape, cell placement, orientation– attained? Is it an intrinsic property of the interactions between its components (self-organization) or does it depend on external cues? I will establish a system for the production of neuromast organoids in vitro. This will serve to interrogate the role of self-organization in the process of tissue repair. I will also use a combination of single cell transcriptomics, fluorescence marker imaging, gene editing and pharmacological treatments to collect multidimensional data from cells during neuromast regeneration. The use of unbiased computational techniques derived from machine learning will help us untangle the molecular and cellular players driving cellular organization in this system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences computer and information sciences artificial intelligence machine learning
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
85764 Neuherberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.